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Rivive Coupon - Rivive two 4mg nasal sprays box

Rivive

naloxone
Used for Opioid Overdose
Used for Opioid Overdose

RiVive (naloxone) is a life-saving medication for emergency treatment of an opioid overdose. It works as an opioid antagonist to help reverse the effects of opioids. RiVive (naloxone) comes as a nasal spray that gives one dose. It can work as quickly as 2 to 3 minutes to help someone who's overdosed. But the effects only last 30 to 90 minutes. So, it's important to call for medical help right after using. When the person wakes up, they could have signs of opioid withdrawal like shaking, sweating, and nausea. You can get RiVive (naloxone) over-the-counter without a prescription.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on September 9, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesPricesMedicare
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What is RiVive (naloxone)?

What is RiVive (naloxone) used for?

How RiVive (naloxone) works

RiVive (naloxone) is an opioid antagonist. It works by blocking opioid receptors in the brain. This blocks opioids from attaching to its receptor and causing dangerous effects. This includes slow breathing, extreme sleepiness, and loss of consciousness.

By blocking the effects of the opioid, RiVive (naloxone) can help someone who has overdosed. It can help wake them up and get their breathing back to normal.

Are you looking for information on naloxone nasal spray (Narcan) instead?
When does RiVive (naloxone) start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsRiVive
Drug Class Opioid antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityOver-the-counter
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What are the side effects of RiVive (naloxone)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache
  • Dry nose
  • Stuffy nose
  • Swollen or inflamed nose

Other Side Effects

  • Muscle pain
  • Change in taste
  • Stomach pain
  • Opioid withdrawal symptoms (e.g., nausea, vomiting, body ache, sweating, shaky)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
When do RiVive (naloxone) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Irritation in the nose
Nausea
Muscle pain
Other signs of opioid withdrawal

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of RiVive (naloxone)

thumbs-up

Pros

Can help save the life of someone who has overdosed on opioids

Comes as an easy-to-use nasal spray

Available over the counter

thumbs-down

Cons

Must give right away and doesn't take the place of emergency medical care

Might need to give more than one dose if the person doesn't wake up

Can have some side effects that look like withdrawal (like shaking, sweating, or nausea)

pharmacist-tips

Pharmacist tips for RiVive (naloxone)

pharmacist

  • When someone has an opioid overdose, they usually can't give themselves RiVive (naloxone). This is because they might not be awake or they can't breathe well.

    • It's important for family and friends to know the signs of an opioid overdose so they can help. Someone who has overdosed can be extremely sleepy or passed out. They could also have trouble breathing, a slow pulse, and cold or clammy skin.

      • Make sure family and friends know how to give RiVive (naloxone) in an emergency. Give it as soon as you notice someone having signs and symptoms of an opioid overdose. It can help lower the risk of serious harm or death from the overdose.

        • Call 911 or get emergency medical help right after you give someone RiVive (naloxone). The person who overdosed will likely need more help. While you wait for the paramedics to get there, keep checking how the person is doing. Give them more doses of RiVive (naloxone) if they need it until help arrives.

          • Check if the RiVive (naloxone) you have has expired from time to time. It's important to make sure it's still good so you can use it when you need it. Expired RiVive (naloxone) might not work as well when given in an emergency situation. This can lead to life-threatening problems.

            • Be sure RiVive (naloxone) stays at room temperature (68ºF to 77ºF). Don't put it in the refrigerator or keep in high heat.

              How to give RiVive (naloxone):

              • Each RiVive (naloxone) nasal spray contains only 1 dose of medication and can't be reused. Don't test the nasal spray before giving it. This will waste all or some of the medication.

                • Check if you think someone has had an opioid overdose: If someone is passed out, is very sleepy, or not breathing well, shake them gently to try to wake them up.

                  • If the person doesn't wake up, give the 1st dose of RiVive (naloxone): Lay the person on their back and gently tilt their head back. Hold RiVive (naloxone) in one hand. Your index and middle finger should be resting on either side of the nozzle and your thumb on the plunger. Place the nozzle into one nostril, and press the plunger firmly. Roll the person so they're laying on their side.

                    • Call 911 and stay with the person until the paramedics get there: Get emergency medical help right after giving RiVive (naloxone). Stay until help arrives.

                      • While you're waiting for medical help to arrive: Check if the person wakes up or improves after 2 to 3 minutes of giving RiVive (naloxone). If they don't, give another dose in the other nostril with a new RiVive (naloxone) device. Keep giving another dose every 2 to 3 minutes until the person wakes up or medical help gets there.

                        faqs

                        Frequently asked questions about RiVive (naloxone)

                        When should I give someone RiVive (naloxone)?
                        Give someone RiVive (naloxone) right away if they show signs of an opioid overdose. The person could be very sleepy, passed out, or limp. They could have trouble breathing or stop breathing altogether. Other signs include small "pinpoint" pupils or bluish lips and fingertips. Also call 911 for medical help. Give RiVive (naloxone) even if you're not sure it's an opioid overdose. It won't hurt someone who isn't overdosing, but it can save a life if they are.
                        Where can I buy RiVive (naloxone)?
                        You can buy RiVive (naloxone) at your local pharmacy if they have it in stock. This medication is available over the counter without a prescription. Ask the pharmacist if you need help finding it in the pharmacy.
                        How long does RiVive (naloxone) take to work?
                        RiVive (naloxone) can work in 2 to 3 minutes after you give it to someone who has an opioid overdose. In that time, the medication can reverse the effects of opioids. It can help the person wake up and breathe normally again. But remember that one dose of RiVive (naloxone) sometimes isn't enough. If the person doesn't wake up or start breathing again after 2 to 3 minutes, give a spray in the other nostril using a new RiVive (naloxone) device. Keep giving a spray in one nostril every 2 to 3 minutes, if needed, until paramedics get there.
                        How long does RiVive (naloxone) last?
                        After you give RiVive (naloxone), the medication helps reverse the effects of opioids for 30 to 90 minutes. But most opioids stay in the body longer than that. Because of this, overdose effects can come back after RiVive (naloxone) wears off. This can happen even if the person seemed to get better at first. That's why it's important to always call 911 and stay with the person until medical help gets there. You might need to give another dose of RiVive (naloxone) while you wait.
                        How many times can I reuse RiVive (naloxone)?
                        You can only use each RiVive (naloxone) nasal spray one time. But you can give RiVive (naloxone) as many times as you need to. One dose isn't always enough to stop an overdose. Give a dose of RiVive (naloxone) every 2 to 3 minutes until the person who has overdosed starts to wake up or breathe normally. For each dose, remember to use a new RiVive (naloxone) nasal spray.
                        Is RiVive (naloxone) FDA approved?
                        Yes, the FDA has approved RiVive (naloxone). It's the second FDA-approved naloxone nasal spray that you can buy without a prescription. It can help save someone from a dangerous opioid overdose.
                        What's the difference between RiVive and Narcan?
                        RiVive and Narcan are both naloxone nasal sprays used for opioid overdoses. The main difference is how much naloxone is in each spray. RiVive has 3 mg of naloxone per spray, and Narcan has 4 mg. According to RiVive's manufacturer, 3 mg of naloxone can help restore breathing with a low risk of full-blown opioid withdrawal. Another difference is how they're available. Narcan is available as a brand-name and generic version, by prescription or over the counter. RiVive is a brand-name medication only and is sold over the counter. Talk to a healthcare professional to compare and see which is a better option for you.
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                        What are the risks and warnings for RiVive (naloxone)?

                        RiVive (naloxone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Opioid withdrawal

                        • Risk factors: Have taken opioids regularly for a long time

                          Someone who has been given RiVive (naloxone) and has waken up might not feel well right after. These side effects can look like opioid withdrawal. This happens because the medication works to block the effects of opioids very quickly.

                          The person could feel shaky, nauseous, angry, or sweaty. They might also have body aches and a pounding heart and feel anxious or irritable.

                          Watch for these symptoms in someone who has just been given RiVive (naloxone). Tell the paramedics about these symptoms when they get there.

                          risk-warning

                          Risk of symptoms of opioid overdose coming back

                          • Risk factors: Taking long-acting opioids

                            After you give it, RiVive (naloxone) helps reverse the effects of an opioid overdose. But the medication only works for 30 to 90 minutes. And, most opioids stay in the body for much longer than that. This means that the overdose effects can come back after RiVive (naloxone) wears off, even if the person got better at first.

                            That's why it's important to always call 911 when someone has an opioid overdose. After giving them RiVive (naloxone), make sure to stay with them until medical help gets there. Stay even if they look like they're getting better. You might need to give another dose of RiVive (naloxone) while you wait.

                            dosage

                            RiVive (naloxone) dosage forms

                            The average cost for 1 box of two 4mg nasal sprays of RiVive (naloxone) is $38.46 with a free GoodRx coupon. This is 27.13% off the average retail price of $52.78.
                            box
                            Box
                            DosageQuantityPrice as low asPrice per unit
                            two 4mg nasal sprays1 box$38.46$38.46

                            Typical dosing for RiVive (naloxone)

                            Each spray of RiVive has 3 mg of naloxone.

                            The typical dose is 1 spray in one nostril as a single dose. Call 911 right after giving it.

                            If the person doesn't get better in 2 to 3 minutes, give a spray in the other nostril using a new RiVive (naloxone) device. Keep giving a new spray in one nostril every 2 to 3 minutes, if needed, until medical help arrives.

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                            How much does RiVive (naloxone) cost?

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                            Rivive (brand)
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                            alternatives

                            What are alternatives to RiVive (naloxone)?

                            There are a number of medications that your doctor can prescribe in place of RiVive (naloxone). Compare a few possible alternatives below.
                            RiVive (naloxone)
                            Used for:
                            $38.46 Lowest GoodRx priceView Prices
                            Naloxone
                            Used for:

                            • Emergency treatment of opioid overdose in children and adults

                            • Raising blood pressure in the case of septic shock - naloxone IV injection only

                            • Post-surgery slowed breathing caused by opioids - naloxone IV injection only

                            $44.14 Lowest GoodRx priceView Prices
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                            RiVive (naloxone) images

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