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Rivive vs. Naloxone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

RiVive

(naloxone)

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Naloxone

 

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Summary for Rivive

Over-the-counter

RiVive (naloxone) is a life-saving medication for emergency treatment of an opioid overdose. It works as an opioid antagonist to help reverse the effects of opioids. RiVive (naloxone) comes as a nasal spray that gives one dose. It can work as quickly as 2 to 3 minutes to help someone who's overdosed. But the effects only last 30 to 90 minutes. So, it's important to call for medical help right after using. When the person wakes up, they could have signs of opioid withdrawal like shaking, sweating, and nausea. You can get RiVive (naloxone) over-the-counter without a prescription.

Indications for Rivive

Pros and Cons for Rivive

Pros

  • Can help save the life of someone who has overdosed on opioids
  • Comes as an easy-to-use nasal spray
  • Available over the counter

Cons

  • Must give right away and doesn't take the place of emergency medical care
  • Might need to give more than one dose if the person doesn't wake up
  • Can have some side effects that look like withdrawal (like shaking, sweating, or nausea)

Common Side Effects for Rivive

  • Headache
  • Dry nose
  • Stuffy nose
  • Swollen or inflamed nose

Warnings for Rivive

  • Opioid withdrawal
  • Risk of symptoms of opioid overdose coming back

Summary for Naloxone

Prescription or over-the-counter

Naloxone is a life-saving medication that's used to reverse the effects of an opioid overdose. This medication can help a person's breathing return to normal in as quickly as 2 to 3 minutes. The effects of naloxone only lasts 30 to 90 minutes, so it's important for a person who's experiencing an opioid overdose to get medical help right away. Naloxone comes in 2 different forms, a nasal spray (Kloxxado, Narcan, and generic) and auto-injector (Zimhi). You can get naloxone without a prescription.

Indications for Naloxone

  • Emergency treatment of opioid overdose in children and adults
  • Raising blood pressure in the case of septic shock - naloxone IV injection only
  • Post-surgery slowed breathing caused by opioids - naloxone IV injection only

Pros and Cons for Naloxone

Pros

  • Can help save the life of someone who has overdosed on opioids
  • Can be used in both adults and children
  • Works quickly to reverse the effects of opioids
  • Comes as an easy-to-use nasal spray and auto-injector
  • Available without a prescription from provider

Cons

  • Has to be given right away and doesn't take the place of emergency medical care
  • Might need to give multiple doses
  • Can cause opioid withdrawal symptoms, such as body aches, anxiety, sweating, and vomiting
  • Effects start to wear off in 30 to 90 minutes

Common Side Effects for Naloxone

Naloxone nasal spray (Narcan, Kloxxado, generic naloxone):

  • Temporary higher blood pressure
  • Headache
  • Dry nose
  • Nasal congestion
  • Swollen or inflamed nose
  • Nose pain

Naloxone auto-injector (Zimhi)

  • Nausea
  • Feeling dizzy or lightheaded

Warnings for Naloxone

  • Opioid withdrawal
  • Worsening symptoms of opioid overdose
  • Limited effectiveness
  • Heart problems

Prices with our coupons for Rivive vs. Naloxone

Price Card Drug Icon
Rivive1 box / two 4mg nasal sprays
$35.05$51.02
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Price Card Drug Icon
Naloxone1 box / two 4mg nasal sprays
$41.16$68.79
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