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Riluzole

Riluzole Side Effects

Cydnee Ng, PharmDAllison Gourley, PharmD
Reviewed by Cydnee Ng, PharmD, Allison Gourley, PharmD
Last reviewed on September 16, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Mouth numbness (29% for the liquid form, 38% for the oral film)
  • Body weakness or lack of energy (19%)
  • Nausea (16%)
  • Breathing problems (shortness of breath, wheezing, inability to catch your breath, 10%)
  • Stomach pain (5%)
  • Higher blood pressure (5%)

Less Common Side Effects

  • Dizziness
  • Vomiting
  • Dry mouth
  • Joint pain
  • Trouble sleeping
  • Itching
  • Fast heartbeat

Riluzole serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Liver problems: stomach pain, dark urine, yellowing of your skin or eyes
  • Low white blood cells: getting infections, fevers, or sore throat often, feeling extremely tired
  • Breathing problems: dry cough, fast or shallow breathing, shortness of breath
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Source: DailyMed

The following Riluzole side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bladder pain

bloody or cloudy urine

blurred vision

chills

cough

dark urine

diarrhea

difficult, burning, or painful urination

fast, pounding, or irregular heartbeat or pulse

fever

frequent urge to urinate

general feeling of discomfort or illness

headache

increased cough

itching skin

joint pain

loss of appetite

lower back or side pain

muscle aches and pains

nausea

nervousness

persistent loss of appetite or weight loss

pounding in the ears

right upper quadrant tenderness

runny nose

shivering

slow heartbeat

sore throat

trouble sleeping

unusual tiredness or weakness

vomiting

yellow eyes or skin

Incidence not known

Black, tarry, stools

decreased frequency or amount of urine

difficult breathing

increased thirst

nausea

pale skin

swelling of the face, fingers, or lower legs

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

weight gain

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Agitation

back pain

bluish-colored lips, fingernails, or palms

blurred vision

coma

confusion

dark urine

difficulty breathing

dizziness or lightheadedness

drowsiness

fever

headache

irritability

memory loss

pale skin

rapid heart rate

seeing, hearing, or feeling things that are not there

seizures

sore throat

stiff neck

unusual bleeding or bruising

unusual tiredness or weakness

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

lack or loss of strength

Less common

Difficulty moving

dizziness or lightheadedness

dry mouth

excess air or gas in the stomach or bowels

feeling of constant movement of self or surroundings

full feeling

muscle stiffness

passing gas

rapid weight gain

sensation of spinning

skin rash, encrusted, scaly and oozing

sleepiness or unusual drowsiness

stomach pain

tingling of the hands or feet

unusual weight gain or loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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