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Restora Rx

folic acid / lactobacillus casei
Used for Anemia

Restora Rx is a combination dietary supplement that contains folic acid and a probiotic (lactobacillus). According to the manufacturer, Restora Rx can help support gut health for people over 12 years old. It's a capsule that's taken by mouth once daily. But Restora Rx requires a prescription from a healthcare professional (HCP). It isn't common to have side effects from this supplement.

Reviewed by:Last reviewed on January 6, 2025
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What is Restora Rx?

What is Restora Rx used for?

How Restora Rx works

Restora Rx is a combination of two different dietary supplements.

  • Folic acid is a vitamin that helps your body make healthy red blood cells, new tissues, and proteins.
  • Lactobacillus casei (or probiotic KE-99) is a particular species of "good" bacteria that might provide many health benefits, including supporting your gut health.

Drug facts

Common BrandsRestora Rx
Drug ClassDietary supplement
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Side effects of Restora Rx

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

See "Other Side Effects."

Less Common Side Effects

Source: DailyMed

The following Restora Rx side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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Pros and cons of Restora Rx

Pros

  • Taken once a day
  • Can keep at room temperature

Cons

  • Can't use in children younger than 12 years old
  • Can't purchase over the counter; requires a prescription
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Pharmacist tips for Restora Rx

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  • Take Restora Rx between meals, unless your prescriber gave you different directions.
  • Keep Restora Rx in a dry area at room temperature, between 59 and 86 degrees Fahrenheit. You don't need to refrigerate the supplement.
  • Speak with your prescriber before you start taking Restora Rx if you have a weak immune system. Your prescriber can make sure it's safe for you to take since you might be at higher risk for side effects like bloating and gas.
  • Talk to your healthcare team before you start taking Restora Rx if you're pregnant, planning to become pregnant, or breastfeeding. It's not known whether Restora Rx can harm an unborn baby or breastfeeding infant.
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Common questions about Restora Rx

No, Restora Rx isn't available over the counter. It requires a prescription from a healthcare professional (HCP). There's another supplement from the same manufacturer called Restora containing fish oil and lactobacillus that's available over the counter. Ask an HCP which product would be better for you.

You can get Restora Rx at many pharmacies in the U.S. with a prescription from a healthcare professional. Keep in mind that your pharmacy might not have it in stock all the time, but they can order it for you. It can take a few days for the pharmacy to get the shipment. Call your local pharmacy ahead of time before you plan on getting Restora Rx to make sure they have it in stock so they can fill your prescription.

Yes, Restora Rx contains 1.25 mg of folic acid. There's some research suggesting that people who have problems with their gut might also have trouble absorbing folic acid from food. Low folic acid levels might also cause diarrhea. Taking a supplement that contains folic acid like Restora Rx might help restore folic acid levels in your body. Ask a healthcare professional whether Restora Rx is right for your particular stomach problem.

Maybe. Probiotics like Restora Rx promote gut health and can probably help improve constipation, gas, bloating, and diarrhea. These are common symptoms of irritable bowel syndrome, or IBS. But more research and evidence is needed to say for sure that probiotics can greatly help improve these digestive problems. Speak with a healthcare professional about whether Restora Rx is right for you.

Although both Restora Rx and Restora help support your gut health, they are different medications. Restora Rx contains folic acid and lactobacillus, and it's only available with a prescription from a healthcare professional. Restora contains fish oil and lactobacillus, and it's available to purchase over the counter. Speak with your prescriber to compare and see which medication works best for you.

Speak with your prescriber about taking Restora RxIf you have a weak immune system (immunocompromised). They can make sure this product is safe for you to take. People with a weak immune system have a higher risk of side effects and possible infection when they take products with live bacteria, like probiotics. Your prescriber will follow up with you about any side effects you have from the product.

Discuss with your prescriber if you should take a probiotic like Restora Rx if you've been prescribed an antibiotic. Sometimes, healthcare professionals recommend taking a probiotic with antibiotics. Antibiotics can sometimes get rid of the "good bacteria" in your gut, which can cause stomach upset as a side effect. Probiotics might help replace the bacteria that's lost from antibiotic use and help relieve stomach-related side effects. Be sure to separate when you take Restora Rx and your antibiotics by at least 2 hours. This helps prevent them from interfering with each other and making both the probiotic and antibiotics work less well. You can also wait until after you finish your antibiotic treatment to take Restora Rx.

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Risks and warnings for Restora Rx

Restora Rx can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Must treat low vitamin B12 levels separately

  • Risk factors: Low vitamin B12 levels

Don't take Restora Rx to treat certain types of anemia called pernicious anemia and megaloblastic anemia. Restora Rx contains folic acid and can improve your folic acid levels. But the amount of folic acid in the supplement can hide some signs of pernicious anemia. Make sure you discuss with your prescriber about an appropriate treatment plan for you.

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Restora Rx dosage

The average cost for 1 carton of 30 capsules of 1.25mg/60mg of Restora Rx is $48.97 with a free GoodRx coupon. This is 10.51% off the average retail price of $54.72.
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DosageQuantityPrice as low asPrice per unit
30 capsules of 1.25mg/60mg1 carton$48.97$48.97

Typical dosage for Restora Rx

Each capsule contains 1.25 mg of folic acid and 60 mg of Lactobacillus casei.

Adults and children 12 years and older: The typical dose is 1 capsule by mouth once daily, or as prescribed by a healthcare professional (HCP).

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What are alternatives to Restora Rx?

There are a number of medications that your doctor can prescribe in place of Restora Rx. Compare a few possible alternatives below.
Restora Rx
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References

Best studies we found

Hill, D., et al. (2018). The Lactobacillus casei group: History and health related applications. Frontiers in Microbiology.

MedlinePlus. (2023). Folate deficiency.

MedlinePlus. (2024). Pernicious anemia.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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