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Restora Rx

folic acid / lactobacillus casei
Used for Anemia
Used for Anemia

Restora Rx is a combination dietary supplement that contains folic acid and a probiotic (lactobacillus). According to the manufacturer, Restora Rx can help support gut health for people over 12 years old. It's a capsule that's taken by mouth once daily. But Restora Rx requires a prescription from a healthcare professional (HCP). It isn't common to have side effects from this supplement.

Reviewed by:
reviewer
Yen Nguyen, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on January 6, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesReferencesPricesMedicare
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What is Restora Rx?

What is Restora Rx used for?

How Restora Rx works

Restora Rx is a combination of two different dietary supplements.

  • Folic acid is a vitamin that helps your body make healthy red blood cells, new tissues, and proteins.

  • Lactobacillus casei (or probiotic KE-99) is a particular species of "good" bacteria that might provide many health benefits, including supporting your gut health.

Are you looking for information on Restora (lactobacillus casei / omega-3 fatty acids) instead?

Drug Facts

Common BrandsRestora Rx
Drug ClassDietary supplement
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$56.49(save 12.13%)
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$49.64
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What are the side effects of Restora Rx?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

See "Other Side Effects."

Other Side Effects

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Restora Rx

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Pros

Taken once a day

Can keep at room temperature

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Cons

Can't use in children younger than 12 years old

Can't purchase over the counter; requires a prescription

pharmacist-tips

Pharmacist tips for Restora Rx

pharmacist

  • Take Restora Rx between meals, unless your prescriber gave you different directions.

    • Keep Restora Rx in a dry area at room temperature, between 59 and 86 degrees Fahrenheit. You don't need to refrigerate the supplement.

      • Speak with your prescriber before you start taking Restora Rx if you have a weak immune system. Your prescriber can make sure it's safe for you to take since you might be at higher risk for side effects like bloating and gas.

        • Talk to your healthcare team before you start taking Restora Rx if you're pregnant, planning to become pregnant, or breastfeeding. It's not known whether Restora Rx can harm an unborn baby or breastfeeding infant.

          faqs

          Frequently asked questions about Restora Rx

          Is Restora Rx over the counter?
          No, Restora Rx isn't available over the counter. It requires a prescription from a healthcare professional (HCP). There's another supplement from the same manufacturer called Restora containing fish oil and lactobacillus that's available over the counter. Ask an HCP which product would be better for you.
          Where can I buy Restora Rx?
          You can get Restora Rx at many pharmacies in the U.S. with a prescription from a healthcare professional. Keep in mind that your pharmacy might not have it in stock all the time, but they can order it for you. It can take a few days for the pharmacy to get the shipment. Call your local pharmacy ahead of time before you plan on getting Restora Rx to make sure they have it in stock so they can fill your prescription.
          Does Restora Rx have folic acid?
          Yes, Restora Rx contains 1.25 mg of folic acid. There's some research suggesting that people who have problems with their gut might also have trouble absorbing folic acid from food. Low folic acid levels might also cause diarrhea. Taking a supplement that contains folic acid like Restora Rx might help restore folic acid levels in your body. Ask a healthcare professional whether Restora Rx is right for your particular stomach problem.
          Does Restora Rx help with IBS?
          Maybe. Probiotics like Restora Rx promote gut health and can probably help improve constipation, gas, bloating, and diarrhea. These are common symptoms of irritable bowel syndrome, or IBS. But more research and evidence is needed to say for sure that probiotics can greatly help improve these digestive problems. Speak with a healthcare professional about whether Restora Rx is right for you.
          What's the difference between Restora Rx and Restora?
          Although both Restora Rx and Restora help support your gut health, they are different medications. Restora Rx contains folic acid and lactobacillus, and it's only available with a prescription from a healthcare professional. Restora contains fish oil and lactobacillus, and it's available to purchase over the counter. Speak with your prescriber to compare and see which medication works best for you.
          Can I take Restora Rx if I have a weak immune system?
          Speak with your prescriber about taking Restora RxIf you have a weak immune system (immunocompromised). They can make sure this product is safe for you to take. People with a weak immune system have a higher risk of side effects and possible infection when they take products with live bacteria, like probiotics. Your prescriber will follow up with you about any side effects you have from the product.
          Can I take Restora Rx with my antibiotics?
          Discuss with your prescriber if you should take a probiotic like Restora Rx if you've been prescribed an antibiotic. Sometimes, healthcare professionals recommend taking a probiotic with antibiotics. Antibiotics can sometimes get rid of the "good bacteria" in your gut, which can cause stomach upset as a side effect. Probiotics might help replace the bacteria that's lost from antibiotic use and help relieve stomach-related side effects. Be sure to separate when you take Restora Rx and your antibiotics by at least 2 hours. This helps prevent them from interfering with each other and making both the probiotic and antibiotics work less well. You can also wait until after you finish your antibiotic treatment to take Restora Rx.
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          What are the risks and warnings for Restora Rx?

          Restora Rx can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Must treat low vitamin B12 levels separately

          • Risk factors: Low vitamin B12 levels

            Don't take Restora Rx to treat certain types of anemia called pernicious anemia and megaloblastic anemia. Restora Rx contains folic acid and can improve your folic acid levels. But the amount of folic acid in the supplement can hide some signs of pernicious anemia. Make sure you discuss with your prescriber about an appropriate treatment plan for you.

            dosage

            Restora Rx dosage forms

            The average cost for 1 carton of 30 capsules of 1.25mg/60mg of Restora Rx is $49.64 with a free GoodRx coupon. This is 12.13% off the average retail price of $56.49.
            carton
            Carton
            DosageQuantityPrice as low asPrice per unit
            30 capsules of 1.25mg/60mg1 carton$49.64$49.64

            Typical dosing for Restora Rx

            Each capsule contains 1.25 mg of folic acid and 60 mg of Lactobacillus casei.

            Adults and children 12 years and older: The typical dose is 1 capsule by mouth once daily, or as prescribed by a healthcare professional (HCP).

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            How much does Restora Rx cost?

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            Restora Rx (brand)
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            alternatives

            What are alternatives to Restora Rx?

            There are a number of medications that your doctor can prescribe in place of Restora Rx. Compare a few possible alternatives below.
            Restora Rx
            Used for:
            $49.64 Lowest GoodRx priceView Prices
            Restora
            Used for:
            $35.92 Lowest GoodRx priceView Prices

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            References

            Best studies we found

            Hill, D., et al. (2018). The Lactobacillus casei group: History and health related applications. Frontiers in Microbiology.

            MedlinePlus. (2023). Folate deficiency.

            MedlinePlus. (2024). Pernicious anemia.

            View All References (5)

            National Center for Complementary and Integrative Health. (2019). Probiotics: Usefulness and safety.

            National Institutes of Health Office of Dietary Supplements. (2022). Folate: Fact sheet for consumers.

            National Organization for Rare Disorders. (2023). Megaloblastic anemia.

            Ratajczak, A. E., et al. (2021). Does folic acid protect patients with inflammatory bowel disease from complications? Nutrients.

            U.S. Pharmaceutical Corporation. (2023). Restora RX (folic acid, lactobacillus casei- ke-99 capsule [package insert]. DailyMed.

            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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