The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Change in liver lab test results
- Nausea or vomiting
- Diarrhea
- Swelling or sores in the mouth
- Burning of psoriasis skin lesions
- Skin more sensitive to sunlight
- Low platelet levels
Less Common Side Effects
- Headache
- Dizziness
- Rash
- Itchy skin
- Hair loss
- Low white blood cells
Note: Side effects listed here were reported by people who took either the oral or injectable version of methotrexate, including Rasuvo.
Rasuvo serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reaction: rash, trouble breathing, swelling in the face or throat
- Severe skin reaction: blisters, peeling skin, sores in the mouth, fever
- Lung problems: trouble breathing, cough, fever
- Liver damage: stomach pain, nausea, yellowing of the skin or whites of the eyes, dark urine
- Kidney problems: urinating less often than usual, itchy skin, bloody or foamy urine
- Brain or nerve problems: seizures, headache, confusion, weakness on one side of the body, coordination problems, vision problems
- Low blood cell counts: tiredness, easy bruising, blood in urine or stool, pale skin
- Infection: fever, cough, pain while urinating, chills, muscle weakness, vomiting
- Cancerous tumors
Source: DailyMed
More on Rasuvo side effects

The following Rasuvo side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Black, tarry stools
blood in the urine or stools
bloody vomit
joint pain
reddening of the skin
sores in the mouth or lips
stomach pain
swelling of the feet or lower legs
Less common
Back pain
bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
blurred vision
confusion
convulsions (seizures)
cough or hoarseness
dark urine
dizziness
drowsiness
fever or chills
headache
lower back or side pain
painful or difficult urination
pinpoint red spots on the skin
shortness of breath
unusual bleeding or bruising
unusual tiredness or weakness
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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