The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Burning
- Itching
- Skin irritation
- Dry skin
Less Common Side Effects
- Acne-like bumps
- Skin discoloration
- Rash or heat rash
- Thinning skin
- Stretch marks
- Pruning or wrinkling of the skin
- Hair growth
Source: DailyMed
The following Proctofoam HC side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Cushing syndrome—increased fat around the midsection, upper back, neck, or face, pink or purple stretch marks on the skin, thinning, fragile skin that easily bruises, unexpected hair growth
- High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
- Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Change in skin color
- Fragile or thinning skin that bruises easily
- Mild skin irritation, redness, or dryness
- Small, red, pus-filled bumps on skin around hair follicles
- Unexpected hair growth at application site

