Skip to main content
Probenecid

Probenecid Side Effects

Cydnee Ng, PharmDMichelle Nguyen, PharmD
Reviewed by Cydnee Ng, PharmD, Michelle Nguyen, PharmD
Last reviewed on April 12, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache
  • Dizziness
  • Sudden gout attack (sharp pain and swelling at the joints)
  • Nausea
  • Vomiting
  • Kidney stones

Probenecid serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Kidney stone: severe back pain, stomach pain, blood in your urine, fever, chills

Source: DailyMed

The following Probenecid side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Fast or irregular breathing

puffiness or swellings of the eyelids or around the eyes

shortness of breath, troubled breathing, tightness in chest, or wheezing

changes in the skin color of the face occurring together with any of the other side effects listed here

or skin rash, hives, or itching occurring together with any of the other side effects listed here

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Bloody urine

difficult or painful urination

lower back or side pain (especially if severe or sharp)

skin rash, hives, or itching (occurring without other signs of an allergic reaction)

Rare

Cloudy urine

cough or hoarseness

fast or irregular breathing

fever

pain in back and/or ribs

sores, ulcers, or white spots on lips or in mouth

sore throat and fever with or without chills

sudden decrease in the amount of urine

swelling of face, fingers, feet, and/or lower legs

swollen and/or painful glands

unusual bleeding or bruising

unusual tiredness or weakness

yellow eyes or skin

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Headache

joint pain, redness, or swelling

loss of appetite

nausea or vomiting (mild)

Less common

Dizziness

flushing or redness of face (occurring without any signs of an allergic reaction)

frequent urge to urinate

sore gums

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

GoodRx icon

Other Uricosuric Drugs side effects articles

Was this page helpful?