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Krystexxa

Krystexxa Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on May 24, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Gout flare (77%)
  • Infusion reaction (26%)
  • Nausea (12%)
  • Bruising (11%)
  • Runny nose, sore throat, and other symptoms of the common cold (7%)
  • Constipation (6%)
  • Chest pain (6%)
  • Vomiting (5%)

Less Common Side Effects

  • Swelling in arms or legs
  • Feeling unwell
  • Low energy

Krystexxa serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Anaphylaxis (closing of the throat): fainting, lightheadedness, trouble breathing, rash, nausea, vomiting swelling of the lips, tongue, throat, or face
  • Infusion reaction: chest pain, skin redness, itching, hives, flushing, difficulty breathing

Source: DailyMed

The following Krystexxa side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Chest pain or discomfort

cough

difficult or labored breathing

difficulty with swallowing

dizziness

facial swelling

fast heartbeat

fever or chills

flushing or redness of the skin

gout flare

headache

hives or welts, itching, or skin rash

nausea or vomiting

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of the skin

tightness in the chest

unusual tiredness or weakness

unusually warm skin

Rare

Decreased urine output

dilated neck veins

extreme fatigue

irregular breathing

irregular heartbeat

swelling of the face, fingers, feet, or lower legs

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bruise

contusion

difficulty having a bowel movement (stool)

large, flat, blue, or purplish patches in the skin

muscle aches

sore throat

stuffy or runny nose

Less common

Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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