The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Gout flare (77%)
- Infusion reaction (26%)
- Nausea (12%)
- Bruising (11%)
- Runny nose, sore throat, and other symptoms of the common cold (7%)
- Constipation (6%)
- Chest pain (6%)
- Vomiting (5%)
Less Common Side Effects
- Swelling in arms or legs
- Feeling unwell
- Low energy
Krystexxa serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Anaphylaxis (closing of the throat): fainting, lightheadedness, trouble breathing, rash, nausea, vomiting swelling of the lips, tongue, throat, or face
- Infusion reaction: chest pain, skin redness, itching, hives, flushing, difficulty breathing
Source: DailyMed
The following Krystexxa side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Chest pain or discomfort
difficult or labored breathing
difficulty with swallowing
dizziness
facial swelling
fast heartbeat
fever or chills
flushing or redness of the skin
gout flare
headache
hives or welts, itching, or skin rash
nausea or vomiting
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness of the skin
tightness in the chest
unusual tiredness or weakness
unusually warm skin
Rare
Decreased urine output
dilated neck veins
extreme fatigue
irregular breathing
irregular heartbeat
swelling of the face, fingers, feet, or lower legs
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Bruise
contusion
difficulty having a bowel movement (stool)
large, flat, blue, or purplish patches in the skin
muscle aches
stuffy or runny nose
Less common
Vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

