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Paclitaxel

Paclitaxel Side Effects

Julia Lee, PharmD, BCOPConnie Zheng, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Connie Zheng, PharmD
Last reviewed on August 22, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low blood cell counts (up to 90%)
  • Hair loss (87%)
  • Feeling numbness and tingling (60%)
  • Muscle, bone, or joint pain (60%)
  • Nausea and vomiting (52%)
  • Allergic reaction (41%)
  • Diarrhea (38%)
  • Mouth sores (31%)
  • Infection (30%)

Less Common Side Effects

  • Injection site reactions

Please note: Side effect information is from studies of people who received [[EDITOR|DRUG_DISPLAY_NAME]] alone for ovarian or breast cancer. Your side effect experience might be different depending on your cancer and your treatment plan.

Paclitaxel serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reactions: swelling of the face, lips, or tongue, difficulty swallowing, rash, itching, trouble breathing
  • Lower blood cell counts (serious infections): unusual bleeding or bruising, fever
  • Abnormal heart rhythm: racing heartbeat, feeling lightheaded

Source: DailyMed

The following Paclitaxel side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black or tarry stools

blurred vision

burning, numbness, tingling, or painful sensations

confusion

cough or hoarseness with fever or chills

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

feeling of warmth

fever or chills

lower back or side pain

painful or difficult urination

pale skin

redness of the face, neck, arms, and occasionally, upper chest

shortness of breath

skin rash or itching

sore throat

sweating

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unsteadiness or awkwardness

unusual bleeding or bruising

unusual tiredness or weakness

weakness in the arms, hands, legs, or feet

Less common

Blood in the urine or stools

difficult or labored breathing

pinpoint red spots on the skin

shortness of breath (severe)

slow heartbeat

tightness in the chest

wheezing

Incidence not known

Anxiety

blue lips, fingernails, or skin

difficult or troubled breathing

fainting

fast heartbeat

irregular, fast or slow, or shallow breathing

sudden shortness of breath

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

cracked lips

diarrhea

difficulty with swallowing

hair loss

nausea or vomiting

numbness, burning, or tingling in the hands or feet

pain in the joints or muscles, especially in the arms or legs

thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Julia is a clinical hematology/oncology pharmacist working in the San Francisco Bay Area. She has 3 years of experience as a practicing pharmacist at academic medical centers, with 2 years at National Comprehensive Cancer Network member hospitals.
Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

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