Onpattro
Onpattro (patisiran) is a medication used for treating nerve damage (polyneuropathy) due to hereditary transthyretin-mediated amyloidosis (hATTR). It's given as an injection into the veins every 3 weeks by a healthcare provider.
What is Onpattro (patisiran)?
What is Onpattro (patisiran) used for?
- Polyneuropathy from hereditary transthyretin-mediated amyloidosis (hATTR)
How Onpattro (patisiran) works
Your liver makes a protein called transthyretin (TTR). In people with hereditary transthyretin-mediated amyloidosis (hATTR), the gene that makes TTR has a mutation that causes the protein to fold incorrectly into an unusual shape. This unusual shape causes TTR proteins to clump together in clusters called amyloid deposits or fibrils. These amyloid deposits travel throughout your body and can cause damage to your organs and nerves.
Onpattro (patisiran) is a type of molecule called an small interfering ribonucleic acid (siRNA). It's a piece of genetic material that attaches to the TTR gene and breaks it down. This lowers the amount of misshapened TTR proteins in your body, which lowers the amount of amyloid that builds up in your organs.
Drug facts
Side effects of Onpattro (patisiran)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Upper respiratory infections (29%)
- Infusion-related reactions (19%)
- Indigestion (8%)
- Shortness of breath (8%)
- Muscle spasms (8%)
- Joint pain (7%)
- Skin redness (7%)
- Bronchitis (7%)
- Vertigo or a spinning sensation (5%)
Less Common Side Effects
- Dry eye
- Blurry vision
- Eye floaters
The following Onpattro (patisiran) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
- Low vitamin A level—change in vision, dry eyes, dry skin, frequent infections
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Pros and cons of Onpattro (patisiran)
Pros
- Works well to treat hATTR symptoms
- Injected once every 3 weeks
Cons
- Needs to be given by a healthcare provider
- Brand name only, which can be expensive
- Requires you to take several medications 1 hour before the infusion to prevent infusion-related reactions
Pharmacist tips for Onpattro (patisiran)
- Mark your appointments to see your provider and receive Onpattro (patisiran) on your calendar. This makes sure your providers can properly monitor you and also helps you remember to receive your doses on time.
- The Onpattro (patisiran) infusion takes about an hour and 20 minutes. After your infusion, your provider might want to monitor you for a while just in case you get any reactions to the medication. You can bring a book or something else to do with you to help pass the time.
- It's possible to get infusion-related reactions during your Onpattro (patisiran) infusion. Examples of these reactions include flushing, back pain, nausea, stomach pain, shortness of breath, and headache. If you get any of these reactions during your infusion, tell your provider so they can slow or stop the infusion. They can also give you medications to treat your symptoms.
- It's best to take a daily vitamin A supplement during Onpattro (patisiran) treatment. This is because the medication can lower the vitamin A levels in your blood. Ask your provider how much vitamin A you should take every day.
Common questions about Onpattro (patisiran)
Yes. Since Onpattro (patisiran) can cause infusion reactions, your provider will give you a few medications at least 1 hour before you receive your infusion to help prevent or lessen the severity of these reactions. This is called premedication and typically includes a steroid, two different antihistamines, and acetaminophen (Tylenol).
Onpattro (patisiran) and Tegsedi (inotersen) both work well to treat symptoms of hATTR. The first major difference is how they're given. Onpattro (patisiran) is given by a healthcare provider as an injection through the vein every 3 weeks, but you can inject Tegsedi under the skin by yourself at home once per week. The second major difference is the potential risks. The manufacturer of Onpattro (patisiran) lists infusion reactions as a warning with medication use. On the other hand, Tegsedi can cause serious bleeding or kidney problems, which is why it's only available through the Risk Evaluation and Mitigation Strategy (REMS) program called the Tegsedi REMS program.
If you miss a dose of Onpattro (patisiran), contact your provider so you can receive it as soon as possible. If you get your dose within 3 days of your missed scheduled date, you can continue with your current dosing schedule. If you get your dose more than 3 days after your missed scheduled date, your next doses of Onpattro (patisiran) will be scheduled every 3 weeks from the date you received your dose.
There isn't enough information to know if Onpattro (patisiran) is safe to take during pregnancy. In some animal studies, this medication caused harm to pregnant mothers and their babies. If you're pregnant or thinking of becoming pregnant, talk with your provider about the risks and benefits of using this medication during pregnancy. If you're pregnant and are prescribed Onpattro (patisiran) or if you become pregnant while taking this medication, it's recommended you enroll in a pregnancy registry that monitors your and your baby's health outcomes. Contact the registry by calling 1-877-256-9526.
Since hATTR is a genetic disorder, it cannot be cured. You'll likely need to take Onpattro (patisiran) for the rest of your life, as long as you're not having side effects and it's helping your condition.
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Risks and warnings for Onpattro (patisiran)
Onpattro (patisiran) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Infusion reactions
Onpattro (patisiran) can cause infusion-related reactions while you receive the medication. Examples of these reactions include flushing, back pain, nausea, stomach pain, shortness of breath, and headache. If you develop any of these reactions during your infusion, tell your provider so they can slow or stop the Onpattro (patisiran) infusion. They might also give you medications to treat your symptoms. To prevent or lessen the severity of these reactions, your provider will give you a few medications to take at least 1 hour before your Onpattro (patisiran) infusion. These medications include a steroid (e.g., dexamethasone), acetaminophen (Tylenol), a histamine-2 antagonist (e.g., famotidine), and a histamine-1 antagonist (e.g., diphenhydramine (Benadryl)). Your provider might adjust the dose of these medications or switch to different ones, depending on how you respond to them.
Low vitamin A levels
Onpattro (patisiran) can lower your blood vitamin A levels. It's best to take a vitamin A supplement at the recommended daily dose while taking Onpattro (patisiran). If you're pregnant, speak to your provider about what dose of vitamin A is right for you, because having too much or too little vitamin A can affect the development of your baby. Don't take more than the maximum recommended daily dose to try and raise your vitamin A levels, because this can lead to side effects like nausea, dizziness, or headache. Contact your provider if you get night blindness, because this is an early symptom of very low vitamin A.
Onpattro (patisiran) dosage
Typical dosage for Onpattro (patisiran)
- Weight of less than 220 lbs (100 kg): The typical dose is 0.3 mg/kg of body weight injected into the veins (intravenously or IV) once every 3 weeks.
- Weight of 220 lbs or more: The typical dose is 30 mg IV once every 3 weeks.
What are alternatives to Onpattro (patisiran)?
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