Odomzo
Odomzo (sonidegib) is a targeted cancer medication used to treat a specific kind of skin cancer called basal cell carcinoma that has spread and can’t be removed by surgery. It’s convenient to take because you take it by mouth, but it can have side effects such as muscle spasms and hair loss. Odomzo (sonidegib) is very harmful to an unborn baby and can cause pregnancy loss (miscarriage). People who take Odomzo (sonidegib) who are able to have children must use effective birth control.
What is Odomzo (sonidegib)?
What is Odomzo (sonidegib) used for?
- Advanced basal cell carcinoma (BCC) that can’t be removed by surgery or radiation
How Odomzo (sonidegib) works
There’s a certain pathway in your body called the Hedgehog pathway. It sends signals to help cells grow. It plays an important role in helping unborn babies develop, but it’s not always active in adults. Some people have a mutation in the Hedgehog pathway that makes it active when it shouldn’t be, and this can cause cancer cells to grow, including skin cancer cells.
Odomzo (sonidegib) is a Hedgehog pathway inhibitor. It treats skin cancer by turning this pathway off so that the cancer cells can’t grow or spread as well.
Drug facts
| Common Brands | Odomzo |
|---|---|
| Drug Class | Hedgehog pathway inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Odomzo (sonidegib)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Higher serum creatinine levels (92%)
- Higher creatinine kinase, suggesting muscle injury (61%)
- Muscle spasms (54%)
- Hair loss (53%)
- Higher blood sugar levels (51%)
- Taste changes (46%)
- Higher digestive enzyme levels (43%)
- Tiredness (41%)
- Nausea (39%)
- Muscle pain (32%)
- Lower blood cell count (up to 32%)
- Weight loss (30%)
- Lower appetite (23%)
Less Common Side Effects
- Stomach pain
- Headache
- Pain
- Vomiting
- Itching
The following Odomzo (sonidegib) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Change in taste
- Diarrhea
- Fatigue
- Hair loss
- Loss of appetite with weight loss
- Nausea
Pros and cons of Odomzo (sonidegib)
Pros
- Taken by mouth and only taken once a day
- Recommended treatment option for people with basal cell carcinoma that has - spread and can’t be removed by surgery
- Works in a more specific, targeted way than traditional chemotherapy
Cons
- Causes hair loss in most people
- Can cause muscle spasms and taste changes
- Very unsafe for pregnant females
Pharmacist tips for Odomzo (sonidegib)
- Take Odomzo (sonidegib) on an empty stomach, one hour before or two hours after you eat.
- Because Odomzo (sonidegib) is so unsafe to an unborn baby, it’s important to make sure other people aren’t exposed to the medication. You shouldn’t donate blood or blood products while taking Odomzo (sonidegib) or for 20 months after the last dose. Males taking Odomzo (sonidegib) shouldn’t donate semen until at least 8 months after the last dose.
- Some pre-menopausal females taking Odomzo (sonidegib) stopped menstruating while taking Odomzo (sonidegib). Menstruation usually starts up again after the drug is stopped.
- You might experience diarrhea while taking Odomzo (sonidegib). If you have this side effect, your provider might recommend you take over-the-counter medications, like loperamide (Imodium A-D), to help treat it. Make sure you drink plenty of fluids, but avoid sugary sports drinks because these can make diarrhea worse.
- If you miss a dose of Odomzo (sonidegib), don’t take two doses to make up for it. Just skip the missed dose and start taking it again at the next scheduled time.
- Store Odomzo (sonidegib) out of reach of children. This medication can cause serious harm and growth problems if taken by children.
- Ask your provider about the best way to handle and throw away Odomzo (sonidegib) safely. Anticancer medications can be harmful to people who handle or come in contact with them. You should store the medication up and away, so children and pets won’t be able to reach it.
- Females who are taking Odomzo (sonidegib) shouldn’t breastfeed. Odomzo (sonidegib) hasn’t been studied in human milk, but because of the possible risks to a baby, it’s best to avoid nursing if you’re taking Odomzo (sonidegib) and for 20 months after the last dose.
Risks and warnings for Odomzo (sonidegib)
Odomzo (sonidegib) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Serious harm to unborn baby
- Risk factors: Pregnant females | Males with a partner who can have children
Results from animal studies suggest Odomzo (sonidegib) can cause serious harm or death to an unborn baby. Pregnant females shouldn’t take Odomzo (sonidegib). If you’re a female able to have children, you must have a negative pregnancy test before starting Odomzo (sonidegib). In addition, you need to use effective birth control while taking Odomzo (sonidegib) and for about 2 years after the last dose. Males who have a partner who can have children must use condoms while taking Odomzo (sonidegib) and for at least 8 months after the last dose.
Muscle problems
Most people who take Odomzo (sonidegib) experience muscle spasms, but they are usually mild. Rarely, the spasms can be severe, painful, and cause a high level of creatine phosphokinase (CPK) in your blood that suggests tissue damage. Your provider will measure your CPK level through labs before you start Odomzo (sonidegib) and any time you have muscle pain. If you have painful muscle spasms or aching joints or higher CPK levels, your provider might pause or stop Odomzo (sonidegib) depending on how severe your symptoms are.
Abnormal bone changes in children
Make sure to store Odomzo (sonidegib) out of reach of children. Aside from the possible serious side effects, Odomzo (sonidegib) can cause serious bone problems in growing children.
Odomzo (sonidegib) dosage
Typical dosage for Odomzo (sonidegib)
The usual dose of Odomzo (sonidegib) is 200 mg by mouth once a day on an empty stomach.
