ED A-Hist DM
ED A-Hist DM is a combination medication that contains chlorpheniramine (an antihistamine), dextromethorphan (a cough suppressant), and phenylephrine (a decongestant). It's an over-the-counter medication for adults and children to help treat allergy and common cold symptoms, like cough, stuffy or runny nose, and itchy or watery eyes. ED A-Hist DM is available as a tablet or liquid that's taken by mouth every 4 hours for symptom relief. This combination medication can also be found under several different brand names (for example, NoHist DM). Possible side effects include making you feel sleepy, restless, or dizzy and dry mouth.
What is ED A-Hist DM?
What is ED A-Hist DM used for?
Short-term relief of symptoms from allergies and the common cold:
- Runny nose
- Sneezing
- Itchy nose or throat
- Itchy, watery eyes
- Cough from throat and lung irritation
- Stuffy nose (nasal congestion)
How ED A-Hist DM works
ED A-Hist DM is a combination of three medications that work together to relieve symptoms caused by the common cold and allergies.
- Chlorpheniramine is an antihistamine. It blocks histamine, a natural substance in your body that normally causes common cold and allergy symptoms. By blocking histamine, chlorpheniramine lowers inflammation (swelling) and relieves runny or itchy nose, sneezing, and watery eyes.
- Dextromethorphan is a cough suppressant. It works in the brain to lower your urge to cough.
- Phenylephrine is a decongestant that clears your sinuses to relieve sinus pressure.
Drug facts
Side effects of ED A-Hist DM
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness
- Restlessness
- Dizziness
- Dry mouth
Less Common Side Effects
- Headache
- Blurry vision
- Trouble urinating
ED A-Hist DM serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, high fever, confusion
The following ED A-Hist DM side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Heart palpitations—rapid, pounding, or irregular heartbeat
- Increase in blood pressure
- Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
- Trouble passing urine
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Anxiety, nervousness
- Confusion
- Constipation
- Dizziness
- Drowsiness
- Dry mouth
- Fatigue
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Pros and cons of ED A-Hist DM
Pros
- Can treat a wide variety of common cold or allergy symptoms
- Conveniently combines three medications into one product
- Available over the counter
- Available as a tablets and an oral liquid
Cons
- Might need to take as often as every 4 hours to relieve symptoms
- More difficult to customize the dose since it's a fixed combination of three medications
- Might not be the best choice for people over 65 years old; people with glaucoma; or people with heart, breathing, or urinary problems
Pharmacist tips for ED A-Hist DM
- You can take ED A-Hist DM with or without food. If it upsets your stomach, try taking the medication with food.
- If you're using a liquid form of ED A-Hist DM, use a medication dose cup or an oral syringe to measure your dose. Don't use household spoons because they aren't accurate and using them might cause you to take the wrong dose.
- ED A-Hist DM can make you sleepy or dizzy, which can affect your ability to focus, think, or react. Don't drive until you know how the medication affects you. Taking the least amount of medication possible before bed can help lessen sleepiness and its effect on concentration during the daytime.
- Limit or avoid alcohol while you're taking ED A-Hist DM. Alcohol can worsen side effects like sleepiness and dizziness.
- It's possible for children who use ED A-Hist DM to become overly excited or energetic. Stop ED A-Hist DM and speak to a pediatrician if this happens to your child.
- You can use ED A-Hist DM to temporarily relieve cold or allergy symptoms. But let your healthcare team know if your symptoms worsen or last longer than a week. Also tell them if you start to have a fever, rash, or headache. These might be signs that you need more medical attention.
- Stop taking ED A-Hist DM and contact your healthcare team if you experience dizziness, nervousness, or trouble sleeping. These might be side effects from certain ingredients in ED A-Hist DM, such as phenylephrine. Depending on how bothersome these side effects are, your care team might recommend taking a lower dose of ED A-Hist DM or using a different option to relieve your symptoms.
- Talk to a healthcare professional first before starting any new medications — especially other antihistamines, cough suppressants, or decongestants — while you're taking ED A-Hist DM. Taking certain medications with ED A-Hist DM can raise your risk for severe side effects, including seizures, hallucinations (seeing things that aren't real), high blood pressure, and fast heart rate.
- Don't take ED A-Hist DM if you're currently taking or have taken a monoamine oxidase inhibitor (MAOI), such as selegiline or phenelzine (Nardil), in the last 2 weeks. This combination can raise your risk for severe side effects like serotonin syndrome and high blood pressure. Contact your primary care provider or pharmacist for other options to relieve your cough, congestion, and allergy symptoms.
Common questions about ED A-Hist DM
ED A-Hist DM should start to help relieve your allergy and cold symptoms within 30 minutes to 1 hour after you take it.
Yes, it's possible for ED A-Hist DM to make you sleepy. This medication contains chlorpheniramine and dextromethorphan, which both can cause sleepiness as a side effect. But ED A-Hist DM also contains phenylephrine, which can have the opposite effect and keep you awake. See how ED A-Hist DM affects your sleep when you first take it. Contact your primary care provider or pharmacist to discuss better options if the medication makes you too sleepy or if it makes it hard for you to get good rest.
Yes. ED A-Hist DM contains phenylephrine, which is a decongestant that can help relieve sinus pressure and stuffy nose. Be sure to avoid taking more than one medication with a decongestant, like phenylephrine or pseudoephedrine, at the same time. Otherwise, your risk for certain side effects, such as fast heart rate and high blood pressure, might be higher.
No. Don't take diphenhydramine (Benadryl) and ED A-Hist DM together. ED A-Hist DM contains chlorpheniramine. Chlorpheniramine and diphenhydramine are both antihistamines. Taking more than one antihistamine at the same time puts you at risk for overdose, which can potentially cause serious behavioral changes, heart problems, seizures, and sometimes even death. To prevent an accidental overdose, review the active ingredient list on the package label of each of your medications to make sure you're not taking more than one antihistamine. Ask your pharmacist if you're not sure whether you're already taking an antihistamine.
Yes, ED A-Hist DM can help relieve dry cough, but not a wet or productive cough. ED A-Hist DM contains dextromethorphan, which is a cough suppressant that helps lower the urge to cough. Make sure to follow the dosing instructions on the manufacturer's label of the product you're using. Talk to your primary care provider if your cough isn't getting better or if it gets worse after you've taken ED A-Hist DM for a week. You might need to be examined to see what other treatment might work better for you.
Yes, it's generally okay to take ibuprofen (Advil) with ED A-Hist DM if you need pain relief or if you need to lower a fever. Ibuprofen and ED A-Hist DM don't seem to interact with each other. But there are a few things to consider. Ibuprofen has its own set of risks, like kidney problems and worsening heart failure. Additionally, phenylephrine (the decongestant in ED A-Hist DM) and ibuprofen can both raise blood pressure. Ask your primary care provider or pharmacist whether using ED A-Hist DM and ibuprofen (Advil) together is safe for you.
There's not enough information to say whether ED A-Hist DM is safe to take while pregnant. There's conflicting evidence about whether taking phenylephrine (an ingredient in ED A-Hist DM) during pregnancy is linked to a higher risk of birth defects. Don't take ED A-Hist DM if you're pregnant until you've talked to your obstetrician-gynecologist (OB-GYN) or primary care provider first about the risks and benefits of the medication. They can discuss with you about other safe options to treat your cold or allergy symptoms during pregnancy.
Don't take ED A-Hist DM if you're breastfeeding until you've talked to your baby's pediatrician or primary care provider first. Antihistamines like chlorpheniramine, which is found in ED A-Hist DM, can make your baby sleepy or irritable. And phenylephrine, another ingredient in ED A-Hist DM, might lower your milk supply. Your baby's pediatrician or primary care provider can discuss with you about the risks and benefits of taking allergy and cold medications while you're breastfeeding.
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Risks and warnings for ED A-Hist DM
ED A-Hist DM can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Sleepiness
- Risk factors: Taking with alcohol | Taking other medications that cause drowsiness | 65 years or older
ED A-Hist DM commonly causes drowsiness. This can affect your ability to focus, think, and react. This side effect is more likely to happen or be more intense if you're over 65 years old. Drinking alcohol or taking ED A-Hist DM with other medications that cause drowsiness (e.g., opioids, benzodiazepines, sleep medications) can also worsen drowsiness. Be careful and avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how ED A-Hist DM affects you.
Serotonin syndrome
- Risk factors: Taking monoamine oxidase inhibitors (MAOI) 14 days before starting ED A-Hist DM | Taking other medications that raise serotonin levels in your brain
The dextromethorphan in ED A-Hist DM can raise your risk for serotonin syndrome. This is a rare, but potentially life-threatening side effect that happens when there's too much serotonin in the brain. Your risk is higher if you're also taking other medications that affect serotonin levels, such as certain antidepressants, MAOIs, and certain migraine medications.
Make sure your healthcare team knows about all the medications you take or plan to take (including over-the-counter medications and supplements) before starting ED A-Hist DM. Get medical help right away if you have any symptoms of serotonin syndrome, such as fast heart rate, sweating, muscle stiffness or spasms, high fever, and confusion.
Accidentally taking too much medication
ED A-Hist DM contains an antihistamine (chlorpheniramine), cough suppressant (dextromethorphan), and a decongestant (phenylephrine). These ingredients can be found in many other over-the-counter products for allergy, cough, and cold.
The risk of accidentally taking too much medication is higher if you use more than one product containing the same or similar ingredients. Tell your primary care provider or pharmacist about the medications you take before starting ED A-Hist DM. And don't start any new medications without talking to them first. Be sure to carefully read the package labels for its active ingredient list and dosing. Ask your pharmacist if you're not sure whether a product has any similar ingredients and whether it's safe for you.
Early signs that you might've accidentally taken too much medication can include confusion, not being aware of your surroundings, flushed or very warm skin, and vision changes. It can lead to serious side effects, such as anxiety or other behavior changes, high blood pressure, and trouble breathing. Get medical help right away or contact a Poison Control Center at 1-800-222-1222 if you or your loved one accidentally took too much medication.
Worsening of certain medical conditions
- Risk factors: Heart disease or high blood pressure | Thyroid problems | High blood sugar (diabetes) | Glaucoma | Mucus-producing cough | Breathing problems (e.g., emphysema, long-term bronchitis) | Urinary conditions
Let your primary care provider and pharmacist know about all the medical conditions you have before you start taking ED A-Hist DM. Ask them whether this medication is safe for you to take.
ED A-Hist DM might worsen certain medical conditions, like heart disease, high blood pressure, glaucoma, and urination problems. There also might be a better option to treat your symptoms if you have a long-lasting cough with or without mucus, other breathing problems, thyroid problems, or diabetes.
ED A-Hist DM dosage
Typical dosage for ED A-Hist DM
Note: There are several manufacturers that make combination products containing chlorpheniramine, dextromethorphan, and phenylephrine. They each can have different amounts of medication and slightly different dosages. Check the medication label for the specific instructions for your product.
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ED A-Hist DM tablets: Each tablet contains 4 mg of chlorpheniramine, 10 mg of dextromethorphan, and 10 mg of phenylephrine.
- Adults and children 12 years or older: The typical dose is 1 tablet by mouth every 4 hours when you have symptoms. Don't take more than 6 tablets in a 24-hour period.
- Children age 6 years to under 12 years old: The typical dose is one-half tablet by mouth every 4 hours when your child has symptoms. Don't take more than 3 tablets in a 24-hour period.
- Children under 6 years old: Ask your child's pediatrician.
-
ED A-Hist DM liquid or NoHist DM liquid: Each 5 mL (1 teaspoonful) contains 4 mg of chlorpheniramine, 15 mg of dextromethorphan, and 10 mg of phenylephrine.
- Adults and children 12 years or older: The typical dose is 1 teaspoonful (5 mL) by mouth every 4 hours when you have symptoms. Don't take more than 6 doses (30 mL) in a 24-hour period.
- Children age 6 years to under 12 years old: The typical dose is one-half teaspoonful (2.5 mL) by mouth every 4 hours when your child has symptoms. Don't take more than 6 doses (15 mL) in a 24-hour period.
- Children under 6 years old: Ask your child's pediatrician.
How much does ED A-Hist DM cost?
$15.57
ED A-Hist DM contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because ED A-Hist DM will not be safe for you to take.
- Currently take or have taken a monoamine oxidase inhibitor (MAOI) in the last 2 weeks
What are alternatives to ED A-Hist DM?
Short-term relief of symptoms from allergies and the common cold:
ED A-Hist DM images
