Nitisinone

Nitisinone Side Effects

Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD

Last reviewed on April 5, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

High blood tyrosine levels (>10%)

Less Common Side Effects

Low blood cell counts
Pink eye
Inflammation (redness, swelling, irritation) of cornea
Changes in vision
Sensitivity to light

Source: DailyMed

The following Nitisinone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Black, tarry stools

bleeding gums

blindness

blood in the urine or stools

bloody nose

blurred vision

burning, dry, or itching eyes

change in color vision

chest pain or discomfort

chills

cough

decreased vision

difficulty seeing at night

excessive eye tearing

eye redness, irritation, or pain

fever

increased sensitivity of the eyes to sunlight

painful or difficult urination

pinpoint red spots on the skin

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen or painful glands

unusual bleeding or bruising

unusual tiredness or weakness

Rare

Agitation

back pain

bluish color of the fingernails, lips, skin, palms, or nail beds

confusion

cough with mucus

difficulty with breathing

dizziness

drowsiness

fast heartbeat

headache

irritability

seeing or hearing things that are not there

seizures

stiff neck

tightness in the chest

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Dry skin

hair loss or thinning

itching or skin rash

red, swollen skin

scaly skin

Rare

Cold sweats

cool, pale skin

depression

headache

increased hunger