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Ninjacof

chlophedianol / pyrilamine
Used for Allergic Rhinitis
Used for Allergic Rhinitis

Ninjacof is a combination medication containing chlophedianol (a cough suppressant) and pyrilamine (an antihistamine). Adults and children can take it to treat symptoms of allergies and the common cold, such as runny nose, cough, and sneezing. Ninjacof (chlophedianol / pyrilamine) can be found as an over-the-counter liquid solution. It's taken by mouth, typically every 6 to 8 hours. Possible side effects of this medication include dizziness and sleepiness.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on April 24, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesReferencesPricesMedicare
basics-icon

What is Ninjacof (chlophedianol / pyrilamine) ?

What is Ninjacof (chlophedianol / pyrilamine) used for?

Short-term relief of symptoms from allergies and the common cold:

  • Cough

  • Sneezing

  • Runny nose

  • Itchy or watery eyes

  • Itching of the nose and throat

How Ninjacof (chlophedianol / pyrilamine) works

Ninjacof (chlophedianol / pyrilamine) is a combination of two medications:

  • Chlophedianol is a cough suppressant. It relieves coughing by calming the cough control center in the brain.

  • Pyrilamine is an antihistamine. It blocks histamine, a natural chemical in your body that causes congestion (stuffy nose), watery eyes, and sneezing.

Are you looking for information on Ninjacof-D (chlophedianol / pyrilamine / pseudoephedrine) instead?
When does Ninjacof (chlophedianol / pyrilamine) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
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Full effect

Drug Facts

Common BrandsNinjacof
Drug ClassCough suppressant / Antihistamine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityOver-the-counter
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Avg retail price
$17.63(save 22.53%)
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$13.66
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What are the side effects of Ninjacof (chlophedianol / pyrilamine) ?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Stomach upset
  • Trouble urinating
  • Nervousness
  • Trouble sleeping

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Excessive sleepiness or dizziness
  • Overdose: seizures, hallucinations, loss of consciousness, confusion, flushed skin, skin that’s warm to touch, vision changes

Source: DailyMed

pros-and-cons

Pros and cons of Ninjacof (chlophedianol / pyrilamine)

thumbs-up

Pros

Comes as liquid solution, so good option for people who can't swallow tablets

Cotton candy flavor, so might be easier to take

Available over the counter

thumbs-down

Cons

Older adults at higher risk for certain side effects, like dizziness and drowsiness

Might need to take it multiple times a day

Can't change the dose of a single ingredient because it's a combination medication

pharmacist-tips

Pharmacist tips for Ninjacof (chlophedianol / pyrilamine)

pharmacist

  • Ninjacof (chlophedianol / pyrilamine) can be taken with or without food. If it upsets your stomach, try taking the medication with food.

    • Ninjacof (chlophedianol / pyrilamine) comes with a medication dosing cup. Be sure to use this cup to measure your dose of Ninjacof (chlophedianol / pyrilamine) . Don't use household spoons because they might not be accurate and can cause you to take the wrong dose.

      • Ninjacof (chlophedianol / pyrilamine) can make you feel sleepy or dizzy. Don't drive or do anything that requires a lot of focus and attention until you know how this medication affects you.

        • Don't drink alcohol while taking Ninjacof (chlophedianol / pyrilamine) because doing so can worsen sleepiness.

          • Though rare, children who take medications with an antihistamine, such as Ninjacof (chlophedianol / pyrilamine) , might become overly excited or energetic. Let your child's pediatrician know if this happens to your child. They can recommend other options for your child.

            • Stop taking Ninjacof (chlophedianol / pyrilamine) and talk to your primary care provider if your symptoms last longer than a week or you also have a fever, rash, or headache. Also contact them if you develop any new symptoms. These might be signs that you have a more serious condition that needs more medical attention.

              • There isn't much data to know for sure how safe Ninjacof (chlophedianol / pyrilamine) is to take while pregnant or breastfeeding. Ask your healthcare team to see if there are safer options for you.

                faqs

                Frequently asked questions about Ninjacof (chlophedianol / pyrilamine)

                Does Ninjacof (chlophedianol / pyrilamine) make you sleepy?
                Yes, you might feel sleepy after you take Ninjacof (chlophedianol / pyrilamine) . If you're starting Ninjacof (chlophedianol / pyrilamine) for the first time, avoid driving or doing activities that need a lot of focus and attention until you know how this medication makes you feel. It's best to avoid drinking alcohol because alcohol can worsen sleepiness or dizziness. Contact your primary care provider about other treatment options if Ninjacof (chlophedianol / pyrilamine) is making you feel too sleepy to get through the day.
                Do you need a prescription for Ninjacof (chlophedianol / pyrilamine) ?
                If Ninjacof (chlophedianol / pyrilamine) is available at your local pharmacy, you should be able to find it over the counter; this medication doesn't require a prescription. If you're having trouble finding Ninjacof (chlophedianol / pyrilamine) , ask your pharmacist about other antihistamine and cough suppressants that might help ease your symptoms.
                Can you take Ninjacof (chlophedianol / pyrilamine) with diphenhydramine (Benadryl)?
                No, you shouldn't take Ninjacof (chlophedianol / pyrilamine) and diphenhydramine (Benadryl) together because they're both antihistamines. Taking both would only raise your risk for side effects, which can sometimes be serious. Talk to your pharmacist or primary care provider about other options if Ninjacof (chlophedianol / pyrilamine) isn't working well enough for you.
                Can you take acetaminophen (Tylenol) with Ninjacof (chlophedianol / pyrilamine) ?
                There aren't any known interactions between acetaminophen (Tylenol) and Ninjacof (chlophedianol / pyrilamine) . But acetaminophen (Tylenol) might not be a good choice for everyone. For example, it's typically not recommended for people with liver problems, unless taken as directed by their healthcare professional (HCP). Before you use any pain relievers with Ninjacof (chlophedianol / pyrilamine) , speak with your primary care provider or pharmacist to make sure it's safe for you to do so.
                What is the difference between Ninjacof (chlophedianol / pyrilamine) and Bromfed?
                Both Ninjacof (chlophedianol / pyrilamine) and Bromfed DM (brompheniramine / dextromethorphan / pseudoephedrine) are over-the-counter liquid allergy and cold medications that contain an antihistamine and cough suppressant. One main difference between them is that Bromfed DM also contains a decongestant called pseudoephedrine. Because of this, Bromfed DM is considered a restricted medication. If Bromfed DM is available at your pharmacy, you can only purchase it with a valid photo identification behind the pharmacy counter. Ask your pharmacist or primary care provider if you have more questions about Ninjacof and Bromfed DM.
                Is Ninjacof (chlophedianol / pyrilamine) a narcotic?
                No. Ninjacof (chlophedianol / pyrilamine) isn't considered a narcotic because it doesn't have an opioid pain medication in it.
                Is Ninjacof (chlophedianol / pyrilamine) a controlled substance?
                No, Ninjacof (chlophedianol / pyrilamine) isn't a controlled substance because it doesn't have a risk of misuse or dependence.
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                What are the risks and warnings for Ninjacof (chlophedianol / pyrilamine) ?

                Ninjacof (chlophedianol / pyrilamine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Sleepiness

                • Risk factors: Taking more than the recommended dose | Taking other medications that cause drowsiness | Drinking alcohol

                  Ninjacof (chlophedianol / pyrilamine) can make you very sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're over 65 years old, drink alcohol while you're taking this medication, or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications). Don't drive or operate machinery until you know how Ninjacof (chlophedianol / pyrilamine) affects you.

                  risk-warning

                  Worsening of medical conditions

                  • Risk factors: Cough from smoking, asthma, or emphysema | Mucus-producing cough | Breathing problems (e.g., emphysema, long-term bronchitis) | Glaucoma | Urinary problems

                    Don't take Ninjacof (chlophedianol / pyrilamine) if you have any of the risk factors listed above unless your primary care provider said it's safe to do so. Taking Ninjacof (chlophedianol / pyrilamine) can worsen your condition(s) and cause serious side effects. Make sure your primary care provider knows about all medical conditions you have or have had in the past before starting Ninjacof (chlophedianol / pyrilamine) .

                    risk-warning

                    Accidental overdose

                    Ninjacof (chlophedianol / pyrilamine) contains a cough suppressant (chlophedianol) and an antihistamine (pyrilamine), which are in many other over-the-counter products. Using more than one medication containing a cough suppressant and antihistamine, including products used on the skin, can lead to an accidental overdose. This can result in serious side effects, including daytime sleepiness, dizziness, seizures, hallucinations (seeing things that aren't real), or even death.

                    Tell your primary care provider or pharmacist about the medications you take before starting Ninjacof (chlophedianol / pyrilamine) to make sure it's safe for you. Don't start any new medications while taking Ninjacof (chlophedianol / pyrilamine) without talking to your care team. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has a cough suppressant or an antihistamine, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help right away or contact a poison control center at 1-800-222-1222.

                    dosage

                    Ninjacof (chlophedianol / pyrilamine) dosage forms

                    The average cost for 120 ml of 12.5mg/12.5mg of Ninjacof (chlophedianol / pyrilamine) is $13.66 with a free GoodRx coupon. This is 22.53% off the average retail price of $17.63.
                    ml of syrup
                    Ml of syrup
                    DosageQuantityPrice as low asPrice per unit
                    12.5mg/12.5mg120 ml$13.66$0.11

                    Typical dosing for Ninjacof (chlophedianol / pyrilamine)

                    Each 5 mL of Ninjacof (chlophedianol / pyrilamine) contains 12.5 mg of chlophedianol and 12.5 mg of pyrilamine.

                    • People ages 12 years and older: The typical dose is 10 mL by mouth every 6 to 8 hours. The maximum dose is 30 mL in 24 hours, or as directed by your primary care provider.

                    • Children ages 6 to under 12 years old: The typical dose is 5 mL by mouth every 6 to 8 hours. The maximum dose is 15 mL in 24 hours, or as directed by your child's pediatrician.

                    • Children under 6 years old: Ask your child's pediatrician.

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                    How much does Ninjacof (chlophedianol / pyrilamine) cost?

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                    contraindications-icon

                    Ninjacof (chlophedianol / pyrilamine) contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Ninjacof (chlophedianol / pyrilamine) will not be safe for you to take.
                    alternatives

                    What are alternatives to Ninjacof (chlophedianol / pyrilamine) ?

                    There are a number of medications that your doctor can prescribe in place of Ninjacof (chlophedianol / pyrilamine) . Compare a few possible alternatives below.
                    Ninjacof (chlophedianol / pyrilamine)
                    Used for:

                    Short-term relief of symptoms from allergies and the common cold:

                    • Cough

                    • Sneezing

                    • Runny nose

                    • Itchy or watery eyes

                    • Itching of the nose and throat

                    $13.66 Lowest GoodRx priceView Prices
                    Capron DM (dextromethorphan / pyrilamine)
                    Used for:

                    • Cough

                    • Runny nose

                    • Itchy or watery eyes

                    • Itching of the nose and throat

                    $20.18 Lowest GoodRx priceView Prices
                    Nyquil Cough (dextromethorphan / doxylamine)
                    Used for:

                    • Cough caused by minor throat or lung irritation (e.g., common cold)

                    • Runny nose

                    • Sneezing

                    • Watery eyes

                    • Itching

                    $7.56 Lowest GoodRx priceView Prices

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                    References

                    Best studies we found

                    Centers for Disease Control and Prevention. (n.d.). Protect your child: Use the right tool to give the right dose.

                    Centurion Labs, LLC. (2024). Ninjacof- chlorphedianol hcl and pyrilamine maleate solution [package insert]. DailyMed.

                    Department of Justice/Drug Enforcement Administration. (2020). Narcotics.

                    View All References (1)

                    PubChem. (n.d.). Clofedanol. National Library of Medicine.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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