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Ninjacof-D

chlophedianol / pyrilamine / pseudoephedrine
Used for Nasal Congestion
Used for Nasal Congestion

Ninjacof-D is a combination medication that contains chlophedianol (a cough suppressant), pyrilamine (an antihistamine), and pseudoephedrine (a decongestant). It's an over-the-counter medication for adults and children to help treat allergy and common cold symptoms, like cough, stuffy or runny nose, and itchy or watery eyes. It comes as a flavored liquid that's taken by mouth every 6 to 8 hours. Possible side effects include sleepiness, dizziness, and dry mouth.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on May 23, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesReferencesPricesMedicare
basics-icon

What is Ninjacof-D?

What is Ninjacof-D used for?

Short-term relief of symptoms from allergies and the common cold:

  • Cough from throat and lung irritation

  • Runny nose

  • Sneezing

  • Itchy or watery eyes

  • Itching of the nose or throat

  • Stuffy nose (nasal congestion)

How Ninjacof-D works

Ninjacof-D is a combination of three medications that work together to relieve symptoms caused by allergies and the common cold.

Are you looking for information on Ninjacof (chlophedianol / pyrilamine) instead?

Drug Facts

Common BrandsNinjacof-D
Drug ClassCough suppressant / Antihistamine / Decongestant
Controlled Substance ClassificationControlled in some states. See FAQs below.
Generic StatusNo lower-cost generic available
AvailabilityOver-the-counter
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Avg retail price
$16.26(save 18.76%)
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$13.21
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What are the side effects of Ninjacof-D?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Trouble sleeping
  • Feeling restless
  • Changes in blood pressure (up or down)
  • Blurry vision

Source: DailyMed

pros-and-cons

Pros and cons of Ninjacof-D

thumbs-up

Pros

Convenient to take three medications in one liquid product

Starts working within 30 minutes to an hour

Comes in cotton candy flavor for better taste

thumbs-down

Cons

Might need to take every 6 to 8 hours

Higher risk of side effects for people over 65 years old

Only available as a liquid

pharmacist-tips

Pharmacist tips for Ninjacof-D

pharmacist

  • You can take Ninjacof-D with or without food. Try taking the medication with food if it upsets your stomach to help lessen any stomach side effects.

    • Be sure to use the dosing cup inside of the packaging to measure your dose of Ninjacof-D. Don't use household spoons because they might not be accurate and can cause you to take the wrong dose.

      • The chlophedianol (a cough suppressant) and pyrilamine (an antihistamine) in Ninjacof-D can make you feel sleepy or dizzy during the day. Don't drive or do anything that requires a lot of attention or focus until you know how the medication affects you. Also, avoid drinking alcohol because it can make these side effects worse.

        • Ninjacof-D is only meant to be used temporarily to relieve cold or allergy symptoms. If your symptoms worsen or last longer than a week, or you start to have a fever, rash, or headache, let your healthcare team know. These might be signs that you need more medical attention.

          • Stop taking Ninjacof-D and contact your healthcare team if you experience dizziness, nervousness, or trouble sleeping. These might be side effects from the pseudoephedrine or other medications in Ninjacof-D. Depending on how severe your symptoms are, your care team might lower your dose of Ninjacof-D or ask you to consider alternative medications.

            • Don't start any new medications while taking Ninjacof-D, especially other antihistamines, cough suppressants, or decongestants, without talking to a healthcare professional first. Doing so can raise your risk of overdose and severe side effects, including seizures, hallucinations (seeing things that aren't real), high blood pressure and heart rate, or even death.

              • Ninjacof-D shouldn't be taken with a monoamine oxidase inhibitor (MAOI). This combination can raise your risk for severe side effects (e.g., high blood pressure, dizziness). If you're currently taking an MAOI or have taken one in the last 14 days, ask your primary care provider about safer options to treat your cough, congestion, and allergy symptoms.

                faqs

                Frequently asked questions about Ninjacof-D

                Is Ninjacof-D a controlled substance?
                Certain states might consider Ninjacof-D a controlled substance and have put strict regulations on the medication. This is because the pseudoephedrine in Ninjacof-D has the potential to be misused. Keep in mind that state laws change from time to time. So, it’s best to ask your primary care provider or pharmacist whether Ninjacof-D is a controlled substance in your state and how to safely take the medication.
                Is Ninjacof-D over the counter?
                Yes, Ninjacof-D can be purchased at a pharmacy without a prescription. It's usually located at the pharmacy counter (also called behind the counter). You'll need to show photo identification and provide your signature when you buy the medication since it has the potential to be misused. Ask your pharmacist if you have any questions about purchasing Ninjacof-D.
                Does Ninjacof-D make you sleepy?
                You might feel sleepy after taking Ninjacof-D because it contains pyrilamine and chlophedianol, 2 medications that can cause sleepiness. But Ninjacof-D also contains pseudoephedrine, a medication that can make it difficult for you to fall asleep. Speak to your primary care provider if the medication is affecting your sleep and daily activities. There might be better options for you to relieve your symptoms.
                Can you take Ninjacof-D with diphenhydramine (Benadryl)?
                No. Don't take diphenhydramine (Benadryl) with Ninjacof-D because it already contains the antihistamine pyrilamine. Taking multiple antihistamines raises your risk for overdose, which can cause serious side effects such as poor balance and agitation. To prevent an accidental overdose, read the medication box and package labels carefully of all the medications you're taking. If you're not sure if you're already taking an antihistamine, ask your pharmacist for help.
                Does Ninjacof-D have codeine?
                No, codeine isn't one of the ingredients in Ninjacof-D. But it does have chlophedianol in it, which works as a cough suppressant like codeine.
                Can you take acetaminophen (Tylenol) with Ninjacof-D?
                There aren't any known interactions between acetaminophen (Tylenol) and Ninjacof-D. But acetaminophen (Tylenol) isn't a good choice for everyone. For example, it's typically not recommended for people with liver problems, unless taken as directed by their healthcare professional (HCP). Before you use any pain relievers with Ninjacof-D, speak with your primary care provider or pharmacist to make sure it's safe for you to do so.
                Can I take Ninjacof-D if I'm pregnant or breastfeeding?
                There's not enough information to say if Ninjacof-D is safe to take while pregnant or breastfeeding. Some studies show a higher risk of birth defects from taking pseudoephedrine (an ingredient in Ninjacof-D) during pregnancy. Also, pseudoephedrine might lower your milk supply. If you're pregnant or breastfeeding, don't take Ninjacof-D until you've talked to your obstetrician-gynecologist (OB-GYN) first about the risks and benefits of taking the medication. They can also discuss with you about other options to treat your cold or allergy symptoms during pregnancy.
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                What are the risks and warnings for Ninjacof-D?

                Ninjacof-D can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Accidental overdose

                Ninjacof-D contains a cough suppressant (chlophedianol), antihistamine (pyrilamine), and a decongestant (pseudoephedrine), which can be found in many other over-the-counter products. Using more than one medication containing a cough suppressant, antihistamine (including products used on the skin), or decongestant can lead to an accidental overdose and cause serious side effects. These can include high blood pressure, anxiety or other behavior changes, confusion, seizures, hallucinations, or even death.

                Tell your healthcare professional (HCP) or pharmacist about the medications you take before starting Ninjacof-D to make sure it's safe for you. Don't start any new medications while taking Ninjacof-D without talking to your HCP or pharmacist. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has a cough suppressant, antihistamine, or decongestant, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help right away or contact a Poison Control Center at 1-800-222-1222.

                risk-warning

                Worsening of certain medical conditions

                • Risk factors: Heart disease or high blood pressure | Thyroid problems | High blood sugar (diabetes) | Glaucoma | Cough from smoking, asthma, or emphysema | Mucus-producing cough | Breathing problems (e.g., emphysema, long-term bronchitis) | Urinary conditions

                  Ninjacof-D might not be the best choice for you if you're 65 years of age or older, or have certain medical conditions, such as high blood pressure, glaucoma, breathing problems (asthma, or emphysema), thyroid problems, or trouble urinating. Additionally, you might need other treatment if you have a cough that's lasted for a long time, a cough that occurs with smoking, or a cough with a lot of mucus. Let your primary care provider or pharmacist know about the medical conditions you have. Ask them whether Ninjacof-D is safe and appropriate for you to take.

                  dosage

                  Ninjacof-D dosage forms

                  The average cost for 120 ml of 12.5mg/12.5mg/30mg of Ninjacof-D is $13.21 with a free GoodRx coupon. This is 18.76% off the average retail price of $16.26.
                  ml of syrup
                  Ml of syrup
                  DosageQuantityPrice as low asPrice per unit
                  12.5mg/12.5mg/30mg120 ml$13.21$0.11

                  Typical dosing for Ninjacof-D

                  Each 5 mL of solution contains 12.5 mg of chlophedianol, 12.5 mg of pyrilamine, and 30 mg of pseudoephedrine.

                  • Adults and children ages 12 years and older: The typical dose is 5 mL to 10 mL by mouth every 6 to 8 hours. The maximum dose is 40 mL in 24 hours.

                  • Children ages 6 to under 12 years old: The typical dose is 5 mL by mouth every 6 to 8 hours. The maximum dose is 20 mL in 24 hours.

                  • Children under 6 years old: Ask your child's pediatrician.

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                  How much does Ninjacof-D cost?

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                  Ninjacof-D (brand)
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                  $13.21

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                  contraindications-icon

                  Ninjacof-D contraindications

                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Ninjacof-D will not be safe for you to take.
                  alternatives

                  What are alternatives to Ninjacof-D?

                  There are a number of medications that your doctor can prescribe in place of Ninjacof-D. Compare a few possible alternatives below.
                  Ninjacof-D
                  Used for:

                  Short-term relief of symptoms from allergies and the common cold:

                  • Cough from throat and lung irritation

                  • Runny nose

                  • Sneezing

                  • Itchy or watery eyes

                  • Itching of the nose or throat

                  • Stuffy nose (nasal congestion)

                  $13.21 Lowest GoodRx priceView Prices
                  Chlo Tuss
                  Used for:

                  • Cough from throat and lung irritation

                  • Runny nose

                  • Sneezing

                  • Itchy or watery eyes

                  • Itching of the nose or throat

                  • Stuffy nose (nasal congestion)

                  $15.01 Lowest GoodRx priceView Prices
                  Bromfed DM
                  Used for:

                  • Cough

                  • Runny nose

                  • Sneezing

                  • Itchy or watery eyes

                  • Itching of the nose or throat

                  • Stuffy nose (nasal congestion)

                  $10.84 Lowest GoodRx priceView Prices

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                  References

                  Best studies we found

                  Centurion Labs, LLC. (2024). Ninjacof-D- chlophedianol hydrochloride, pyrilamine maleate, pseudoephedrine hydrochloride liquid [package insert]. DailyMed.

                  PubChem. (n.d.). Clofedanol. National Library of Medicine.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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