Neosporin, sometimes known as "triple antibiotic," is a combination antibiotic ointment that contains three active ingredients: bacitracin, polymyxin B, and neomycin. Neosporin is used to help prevent skin infections in minor cuts, scrapes, and burns, as these wounds heal. But it's not meant to treat animal bites, serious burns, or deep puncture wounds - those might require medical attention. It's available over the counter and as a lower-cost generic medication.
Preventing infections in minor cuts, scrapes, and burns
Neosporin is a combination of three antibiotics (bacitracin, polymyxin B, and neomycin) that work together to kill bacteria by making their protective covering weaker and preventing them from making proteins they need to survive.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Combines three antibiotics into one ointment for convenience
Available over the counter
Works well to prevent infections in minor cuts, scrapes, and burns
Comes in different sizes
Available as a lower-cost generic medication
Might need to use it a few times per day
Can be messy to use
Not meant for long-term use
Can't be used to treat infections
Not for use in your eyes, nose, mouth, ears, or genitals
Before using Neosporin, clean the affected area(s) on your skin. Wash your hands before and after using this medication. This will help prevent contamination (the spread of germs).
You should only use Neosporin to prevent infections in your cut. If it looks infected already (red, swollen, pus coming out), you need to see your healthcare provider right away to get proper treatment.
You can use a bandage to cover the affected area after applying Neosporin so it won't get on your clothing.
If you need to use Neosporin longer than 1 week or if the affected areas are getting worse, stop using it and contact your provider. This might be a sign that your wound might need more medical attention.
Neosporin should only be used on small cuts, scrapes, or burns. You shouldn’t use it over large areas of the body or for more serious injuries. If you have deep or puncture wounds, animal bites, or serious burns, ask your provider right away about what you should do to treat your injury.
If you or someone you know accidentally swallows Neosporin, get medical help or contact a Poison Control Center right away by calling 1-800-222-1222.
Store Neosporin at room temperature away from children and pets.
Neosporin can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
In some rare cases, Neosporin can cause an allergic reaction. If you develop a skin rash or other reaction while using this medication, stop using it and contact your provider. If you experience a more serious allergic reaction, such as shortness of breath or swelling of your tongue, lips, or face, get emergency medical help right away.
Neosporin should only be used on your skin. Don’t put it in your eyes, nose, mouth, ears, or genitals. If this medication is swallowed, get medical help or contact a Poison Control Center right away by calling 1-800-222-1222.
Apply a small amount (about the size of the tip of your finger) to the affected area(s) 1 to 3 times daily.
Preventing infections in minor cuts, scrapes, and burns
Preventing bacterial skin infections from small cuts, scrapes, and burns
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American Academy of Dermatology Association. (n.d.). Tattoos: 7 unexpected skin reactions and what to do about them.
American Osteopathic College of Dermatology. (n.d.). Eczema - Infections.
Johnson & Johnson Consumer Inc. (2023). NEOSPORIN ORIGINAL - bacitracin zinc, neomycin sulfate, and polymyxin b sulfate ointment [package insert]. DailyMed.
MedlinePlus. (2015). Neomycin, Polymyxin, and Bacitracin Topical.
Neosporin. (n.d.). Frequently asked questions.
U.S. Food and Drug Administration. (2021). Don’t be tempted to use expired medicines.
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