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naftifine

Generic Naftin
Used for Athlete's Foot, Jock Itch, Ringworm

Naftifine cream is a topical antifungal medication that's used to treat athlete's foot, jock itch, and ringworm. The 1% and 2% strengths are approved for adults. Depending on the type of fungal infection, children of certain ages can also use the 2% strength of the cream. This medication is applied directly onto the affected areas of skin once per day for up to a few weeks. Side effects aren't common but can include itchiness, burning or stinging on the skin, and dry skin.

Reviewed by:Last reviewed on December 11, 2024
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What is Naftifine cream?

What is Naftifine cream used for?

How Naftifine cream works

Naftifine cream is an allylamine antifungal. It isn't clear how the medication exactly works. But it's thought to work by blocking the fungus causing the infection from making important proteins needed for survival.

Drug facts

Common BrandsNaftin(brand name for cream no longer available)
Drug ClassAntifungal
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Naftifine cream

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Burning or stinging on the skin
  • Dry skin
  • Itchiness

Less Common Side Effects

  • Skin redness
  • Skin irritation

Source: DailyMed

The following Naftifine cream side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Burning, stinging, itching, redness, or irritation of the skin

Incidence not known

Blistering or crusting of the skin

softening of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dizziness

headache

Less common

Dry skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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$345.99(Save 76.57%)
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$81.08
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Pros and cons of Naftifine cream

Pros

  • Can treat a few different fungal skin infections (athlete's foot, jock itch, or ringworm)
  • Applied once per day
  • Has few side effects

Cons

  • Available by prescription only
  • Need to use for 2 to 4 weeks
  • Can cause mild skin irritation
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Pharmacist tips for Naftifine cream

pharmacist
  • Use the naftifine cream for the full amount of time that your prescriber recommended (up to 4 weeks for the 1% strength or 2 weeks for the 2% strength). Don't stop using it early, even if your symptoms get better. Stopping treatment too soon can raise the risk that the skin infection can come back.
  • Apply a thin layer of the naftifine cream to the affected areas on your skin. For treating athlete's foot with the 2% strength of the cream, also apply the medication to the skin in between the toes.
  • Make sure to wash your hands with soap and water before you use the naftifine cream. This prevents more germs from getting into the infected areas of skin.
  • Also wash your hands with soap and water after you've applied the naftifine cream, unless you're treating your hands. This lowers the chance that you accidentally get medication in your eyes or other sensitive areas of the body. If the medication gets in your eyes, rinse them well with water.
  • Don't put any naftifine cream in the eyes, mouth, or vagina because it can cause burning and irritation. Be careful if you're applying the medication to the skin around or near those areas. If you accidentally get the naftifine cream in those spots, wash it well with water.
  • Some people can have skin reactions, such as burning, stinging, itching, or irritation, after they apply the naftifine cream. Contact your prescriber if these side effects get worse over time or if you see any blistering, swelling, or oozing. These might be signs of a different, more serious skin condition.
  • Don't cover the areas where you apply the naftifine cream with tight bandages or dressings unless your prescriber tells you to. Usually, you want the area to "breathe" and stay dry so it can heal.
  • If you're pregnant or breastfeeding, talk to a healthcare professional about treatment options for fungal skin infections. There isn't enough information about whether the naftifine cream is safe to use on the skin while pregnant or breastfeeding.
  • Store the naftifine cream at room temperature in a cool and dry spot away from pets and children. Contact your local Poison Center right away at 1-800-222-1222 if a child or animal swallows any of the medication.
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Risks and warnings for Naftifine cream

Naftifine cream can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

For use on the skin only

Only apply naftifine cream to the surface of your skin. Don't put the medication into the eyes, nose, or vagina. Applying naftifine cream to these sensitive areas can cause pain and irritation. Let your prescriber know if your skin becomes very irritated or sensitive as you use this medication. You might have to switch to a different medication.

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Naftifine cream dosage

The average cost for 1 tube of 60g of 2% of Naftifine cream is $157.13 with a free GoodRx coupon. This is 71.24% off the average retail price of $546.30.
tube of creamTube of cream
DosageQuantityPrice as low asPrice per unit
60g of 1%1 tube$92.63$92.63
90g of 1%1 tube$136.70$136.70
45g of 2%1 tube$81.08$81.08
60g of 2%1 tube$98.85$98.85
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Interactions between Naftifine cream and other drugs

Naftifine cream may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Naftifine cream. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

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How much does Naftifine cream cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
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What are alternatives to Naftifine cream?

There are a number of medications that your doctor can prescribe in place of Naftifine cream. Compare a few possible alternatives below.
Naftifine cream
Used for:
$81.08Lowest GoodRx priceView prices
Used for:
$11.02Lowest GoodRx priceView prices

References

Best studies we found

Šveikauskaitė, I., et al. (2020). Potential of naftifine application for transungual delivery. Molecules.

Taro Pharmaceuticals U.S.A., Inc. (2018). Naftifine hydrochloride cream [package insert]. DailyMed.

Xiromed, LLC. (2021). Naftifine hydrochloride cream [package insert]. DailyMed.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.