The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Upper respiratory infection (16%)
- Accidental injury (14%)
- Body pain (13%)
- Joint pain (12%)
- Vaginal discharge (11%)
- Application site reaction (9%)
- Stomach pain (8%)
- Bronchitis (6%)
- Growths on the cervix (6%)
- Breast pain (5%)
- Constipation (5%)
- Indigestion (5%)
- Dizziness (5%)
- Muscle pain or weakness (5%)
- Swelling of the joints (5%)
Less Common Side Effects
- Swelling of the stomach
- Nausea
- Vomiting
- Hot flashes
- Changes in blood pressure
- Palpitations
- Hair loss
- Night sweats
- Excessive sweating
- Vision problems
- Depression
- Headache or migraine
- Anxiety or nervousness
- Mood changes
- Trouble falling asleep (insomnia)
- Fluid retention or swelling (edema)
- Tiredness or weakness
- Weight gain
Menostar serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Stroke: weakness or numbness of arms, legs, or face on one side of the body, slurred speech, blurred vision, headache, dizziness, loss of balance, trouble walking, confusion
- Heart attack: chest pain or discomfort, chest tightness, trouble breathing, nausea, vomiting, dizziness, sweating, fast heartbeat
- Blood clots: legs (cramps, swelling, pain, muscle tightness) and lungs (trouble breathing, chest pain, cough)
- Breast lumps: breast pain or soreness, swelling, rash
- Unusual vaginal bleeding: abnormal spotting or bleeding
Source: DailyMed
The following Menostar side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
- Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
- Gallbladder problems—severe stomach pain, nausea, vomiting, fever
- Increase in blood pressure
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
- Unusual vaginal discharge, itching, or odor
- Vaginal bleeding after menopause, pelvic pain
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Other Menostar articles
Other Estrogens side effects articles
- Vivelle-dot (dotti, estradiol) side effects
- Vagifem (estradiol, yuvafem) side effects
- Climara (estradiol) side effects
- Divigel (estradiol) side effects
- Estrace (estradiol) side effects
- Menostar (estradiol) side effects
- Estrogel (estradiol) side effects
- Delestrogen (estradiol valerate) side effects
- Depo-estradiol side effects

