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Lutathera

Lutathera Side Effects

Julia Lee, PharmD, BCOPDaisy Chau, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Daisy Chau, PharmD
Last reviewed on July 18, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low white blood cell count (up to 90%)
  • Rise in creatinine (85%)
  • High blood sugar (82%)
  • Anemia (81%)
  • Rise in liver enzymes (up to 66%)
  • Nausea (65%)
  • Vomiting (53%)
  • Low platelets (53%)
  • Tiredness (38%)
  • High uric acid (34%)
  • Low calcium (32%)
  • Low potassium (26%)
  • Stomach pain (26%)
  • Diarrhea (26%)
  • Reduced appetite (21%)

Less Common Side Effects

  • Headache
  • Dizziness
  • Swelling or pain in the arms and legs
  • Flushing
  • Back pain
  • Hair loss
  • Anxiety
  • Cough
  • Constipation
  • Fever
  • Changes in taste
  • Muscle pain
  • Neck pain
  • High potassium
  • High sodium
  • Low blood sugar

Lutathera serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: breathing problems, hives, rash, itchiness; swelling of the face, mouth, or lips
  • Hormone gland problems: flushing, diarrhea, difficulty breathing, low blood pressure
  • Low blood cell counts: fever, chills, feeling very tired, dizziness, unusual bleeding or bruising
  • Bone marrow problems and blood cancers: feeling very weak or tired, bruising or bleeding easily, blood in the urine or stool, fevers, unexplained weight loss
  • Kidney problems: making little or no urine, dark urine
  • Liver problems: yellowing of the skin or eyes, dark urine, unusual tiredness, right upper stomach pain, confusion, swelling in the stomach

Source: DailyMed

The following Lutathera side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Flushing, diarrhea, dizziness, feeling faint or lightheaded, blurry vision, wheezing or trouble breathing
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Infection—fever, chills, cough, or sore throat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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