Naproxen vs. Hydrocodone for Pain: 5 Differences in Dosages, Side Effects, and More
Naproxen versus hydrocodone: Both treat pain, but most similarities end there. Learn key differences in side effects, uses, and regulations.
Lortab
Used for Pain
Used for Pain
Lortab is a brand-name, combination medication containing hydrocodone (an opioid) and acetaminophen (an analgesic). It helps manage pain for people who don't get enough relief from non-opioid medications. Lortab (hydrocodone / acetaminophen) comes as tablets and a syrup that are taken by mouth. Common side effects include sleepiness and dizziness.
Please note: Lortab (hydrocodone / acetaminophen) has been discontinued and is no longer available in the United States. Talk to your prescriber about alternative options to manage your pain.
What is Lortab (hydrocodone / acetaminophen)?
What is Lortab (hydrocodone / acetaminophen) used for?
- Pain that isn't relieved by non-opioid pain medications alone
How Lortab (hydrocodone / acetaminophen) works
Lortab (hydrocodone / acetaminophen) is a combination of two medications that work together to treat pain.
- Hydrocodone is an opioid. It attaches to certain mu-opioid receptors in your brain to lower how much pain you feel.
- Acetaminophen is an analgesic. It blocks the production of certain chemicals in your brain that play a role in pain. As a result, acetaminophen helps relieve pain.
Drug facts
| Common Brands | Lortab |
|---|---|
| Drug Class | Opioid / Analgesic |
| Controlled Substance Classification | Schedule II |
| Generic Status | Lower-cost generic available |
| Availability | Discontinued |
More on Lortab (hydrocodone / acetaminophen) essentials
Risks and warnings for Lortab (hydrocodone / acetaminophen)
Lortab (hydrocodone / acetaminophen) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Potential for misuse and addiction
- Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health conditions
Lortab (hydrocodone / acetaminophen) is a controlled substance; it has a risk for misuse and addiction. Take the medication exactly as prescribed. Don't change the dose or how often you take it without talking to your prescriber.
Misusing Lortab (hydrocodone / acetaminophen) might cause the medication to work less well. It can also raise the risk for serious and possibly life-threatening side effects, such as dangerously slow breathing, inability to stay awake, addiction, and opioid overdose. You'll be prescribed the lowest amount of Lortab (hydrocodone / acetaminophen) that's necessary to manage your pain for the shortest amount of time possible.
Because of the risk for misuse, addiction, and overdose, Lortab (hydrocodone / acetaminophen) is only available through a Risk Evaluation and Mitigation Strategy (REMS) program called the Opioid Analgesic REMS program. Your prescriber and pharmacy must register with the program, receive training on proper medication use, and discuss with you about safely taking Lortab (hydrocodone / acetaminophen).
Dangerously slow breathing (respiratory depression)
- Risk factors: Taking medications that can cause slow breathing | Drinking alcohol | Older age | Being frail | Medical conditions that cause breathing problems (e.g., COPD, asthma, head injury) | Taking too much Lortab (hydrocodone / acetaminophen)
Opioids like Lortab (hydrocodone / acetaminophen) can cause dangerously slow breathing, which can be life-threatening. This can happen to anyone and at recommended doses. But the risk is greatest when you first start treatment or when your dose goes up.
Don't drink alcohol while you're taking an opioid medication. And don't take opioids at the same time as other medications that slow your body down (e.g., benzodiazepines, muscle relaxants). Doing so raises your risk of extremely slowed breathing.
Your prescriber might write a prescription for naloxone (Narcan), a medication that can reverse slowed breathing from opioids. Carry it with you at all times. Use naloxone, call 911, and get medical help right away if you or your loved one notices that you have trouble breathing or have bluish-colored lips, fingers, or toes.
Risk for opioid overdose
- Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of Lortab (hydrocodone / acetaminophen) | Taking more opioids than prescribed | Alcohol use
Take opioid medications like Lortab (hydrocodone / acetaminophen) exactly as prescribed. Taking too much or taking them more often than prescribed can lead to an overdose. It can also be very dangerous if someone accidentally swallows the medication. Keep the opioid medication out of reach from children, pets, or visitors to prevent accidental overdose.
Symptoms of an opioid overdose include not responding to sound or touch, extremely slowed breathing, extreme sleepiness, slow heartbeat, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will probably write a prescription for naloxone (Narcan), a medication that can treat an opioid overdose. Carry naloxone with you at all times; use it and call 911 right away if an overdose happens.
Difficulty concentrating and extreme sleepiness
- Risk factors: Taking high doses of Lortab (hydrocodone / acetaminophen) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness
Opioids can cause extreme sleepiness and lower your ability to think, react, and focus. Don't drink alcohol or take other medications that can cause sleepiness or "brain fog" (e.g., benzodiazepines, muscle relaxants, sleep medications) with Lortab (hydrocodone / acetaminophen). Doing so can worsen these side effects.
Be sure you know how opioid medications affect you before driving a car or doing activities that require your concentration. Talk to a healthcare professional (HCP) if you feel too sleepy after taking an opioid medication.
Liver damage
- Risk factors: Drinking alcohol | Taking other medications containing acetaminophen | Taking too much Lortab (hydrocodone / acetaminophen) | History of liver problems
Lortab (hydrocodone / acetaminophen) contains acetaminophen. Taking too much acetaminophen can cause liver damage that can be life-threatening. The risk for liver damage is higher if you're taking more than one medication that contains acetaminophen, if you already have liver problems, or if you regularly drink alcohol.
Tell your prescriber about your medical history, especially if you have liver problems, before you take Lortab (hydrocodone / acetaminophen). Also avoid drinking alcohol while you're taking this medication. Your prescriber can discuss how much acetaminophen you can take per day depending on your age and your risk for liver damage.
Call an HCP right away if you notice any symptoms of liver damage. These symptoms can include tiredness, dark urine, upset stomach, stomach pain, or yellowing of the skin or whites of the eyes.
Drug interactions
Lortab (hydrocodone / acetaminophen) can interact with a lot of medications. Be sure to tell your prescriber and pharmacist about the medications you're taking and planning to take with Lortab (hydrocodone / acetaminophen). Your care team can check that your medications are safe to take together. Also talk to your care team first before making any changes to your medications because sudden dose adjustments can also lead to harm.
Some interactions can raise the level of Lortab (hydrocodone / acetaminophen) in your body. This can raise your risk for serious side effects, including potentially life-threatening slowed breathing. Some examples of medications that interact with Lortab (hydrocodone / acetaminophen) in this way include erythromycin, ketoconazole, and ritonavir (Norvir).
Other drug interactions can lower the levels of Lortab (hydrocodone / acetaminophen) in your body. This can cause the opioid medication to work less well for pain and possibly lead to withdrawal symptoms. These interactions include taking the opioid medication with rifampin (Rifadin) or carbamazepine (Tegretol).
Harm to newborn babies
Long-term use of Lortab (hydrocodone / acetaminophen) during pregnancy can cause your unborn baby to become dependent on the medication. This is because the opioid (hydrocodone) can pass through the placenta to your unborn baby.
Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding behavior, abnormal sleep patterns, and seizures. This can be life-threatening if not recognized and treated in time. Let your HCP know if you've used Lortab (hydrocodone / acetaminophen) or any other opioids during pregnancy or if you notice these symptoms in your baby.
Severe allergic reactions and skin reactions
- Risk factors: Allergy to other opioids
Severe allergic reactions to Lortab (hydrocodone / acetaminophen) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (e.g., closing of the throat). In addition, acetaminophen can rarely cause serious skin reactions, such as rash, blisters, skin reddening, or skin peeling. Get medical help right away if you notice unusual changes in your skin, swelling of the lips or tongue, or difficulty breathing.
Physical dependence and withdrawal
- Risk factors: Long-term use of Lortab (hydrocodone / acetaminophen)
Opioids like Lortab (hydrocodone / acetaminophen) can cause physical dependence when they're taken for a long period of time. This means that your body starts to rely on the medication to function. You might experience withdrawal if you suddenly stop taking the medication or lower your dose too fast. Withdrawal symptoms can be bothersome and include anxiety, restlessness, irritability, sweating, and chills.
Don't lower your dose or stop taking the medication suddenly without talking to your prescriber first. Your prescriber will slowly lower your dose to prevent withdrawal symptoms. Talk to your prescriber about alternative pain medications if you have concerns about the risk for dependence and withdrawal from opioid use.
Low blood pressure
Lortab (hydrocodone / acetaminophen) and other opioids can cause extremely low blood pressure. Your blood pressure might drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to your HCP if any dizziness or lightheadedness doesn't go away.
Low adrenal hormone levels
- Risk factors: Taking Lortab (hydrocodone / acetaminophen) for longer than 1 month
Some people who take opioid medications like Lortab (hydrocodone / acetaminophen) have had low adrenal hormone levels. This might be more likely to happen after taking opioids for longer than 1 month. Symptoms include tiredness, dizziness, weakness, not feeling hungry, and nausea. Tell an HCP if you have these symptoms. If your adrenal hormone levels are too low, you might need to stop Lortab (hydrocodone / acetaminophen) and get treated with corticosteroids.
Seizures
- Risk factors: History of seizure conditions
Opioids such as hydrocodone can raise the risk of having seizures more often in people who've had one before. Opioid medications can also raise your risk of seizures in certain situations. Get medical help right away if you have a seizure while you're taking this medication.
Side effects of Lortab (hydrocodone / acetaminophen)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Lightheadedness
- Dizziness
- Sleepiness
- Nausea
- Vomiting
Less Common Side Effects
- Constipation
- Itching
- Headache
- Tiredness
- "Brain fog"
- Stomach pain
- Changes in blood pressure
Lortab (hydrocodone / acetaminophen) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
- Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, cold or clammy skin, slow heartbeat, upper right-sided stomach pain, dark urine, yellowing of your skin or eyes
- Opioid withdrawal: anxiety, suicidal thoughts, restlessness, runny nose, yawning, sweating, chills, wide pupils, irritability
- Serious allergic reaction or skin reaction: rash, hives, blistering or peeling skin, shortness of breath, fast heartbeat, dizziness, feeling warm suddenly
More on Lortab (hydrocodone / acetaminophen) side effects
The following Lortab (hydrocodone / acetaminophen) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Dizziness
lightheadedness
Incidence not known
Back, leg, or stomach pains
black, tarry stools
bleeding gums
blood in the urine or stools
blood in vomit
bluish lips or skin
chills
choking
dark urine
decrease in the frequency of urination
decrease in urine volume
difficult or trouble breathing
difficulty in passing urine (dribbling)
difficulty with swallowing
fast heartbeat
fever with or without chills
general body swelling
general feeling of tiredness or weakness
headache
hoarseness
irregular, fast or slow, or shallow breathing
light-colored stools
loss of appetite
lower back or side pain
nosebleeds
not breathing
painful or difficult urination
pale or blue lips, fingernails, or skin
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
severe or continuing stomach pain
sore tongue
sores, ulcers, or white spots on the lips or in the mouth
tightness in the chest
unable to speak
unusual bleeding or bruising
unusual tiredness or weakness
upper right abdominal or stomach pain
vomiting
yellow eyes and skin
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Bloody or cloudy urine
change in consciousness
chest pain or discomfort
cold and clammy skin
decreased awareness or responsiveness
extreme drowsiness
general feeling of discomfort or illness
increased sweating
irregular heartbeat
lightheadedness, dizziness, or fainting
loss of consciousness
no blood pressure or pulse
no muscle tone or movement
not breathing
severe sleepiness
slow or irregular heartbeat
stopping of heart
sudden decrease in the amount of urine
unpleasant breath odor
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Drowsiness
relaxed and calm feeling
sleepiness
Incidence not known
Belching
changes in mood
difficulty having a bowel movement
fear or nervousness
feeling of indigestion
hearing loss
impaired hearing
pain in the chest below the breastbone
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Lortab (hydrocodone / acetaminophen)
Pros
- Takes about 30 minutes to help relieve pain
- Combines two pain medications within a single product
Cons
- Has a risk of misuse and dependence
- Not recommended to take with other medications containing acetaminophen since it can raise the risk of liver damage
Pharmacist tips for Lortab (hydrocodone / acetaminophen)
- Opioid medications like Lortab (hydrocodone / acetaminophen) can sometimes make you constipated. Drink enough water every day and add more foods with fiber to your diet. Speak to your care team if these changes aren't enough to help with constipation. They can recommend certain medications or a change in your pain treatment.
- Opioid medications can make you sleepy. They can also lower how clearly you can think or how fast you can react. Don't drive or do activities that you need to be alert for until you know how opioid medications like Lortab (hydrocodone / acetaminophen) affect you.
- Avoid alcohol while you're taking opioids like Lortab (hydrocodone / acetaminophen). This can worsen sleepiness and dizziness and make it hard to think clearly. Taking Lortab (hydrocodone / acetaminophen) with alcohol can also damage your liver.
- Take opioids like Lortab (hydrocodone / acetaminophen) exactly as prescribed. Don't change your dose or stop taking the medication without talking to your prescriber first. Your prescriber might lower your dose slowly over a period of time before you can completely stop the medication. This lowers your risk for bothersome withdrawal symptoms like muscle aches, chills, and trouble sleeping.
- Your prescriber or pharmacist will talk to you about naloxone (Narcan), a medication that can help reverse the effects of opioid medications Lortab (hydrocodone / acetaminophen) in situations like dangerously slowed breathing or an accidental overdose. Teach your loved ones about how to give naloxone to you if you can't do it yourself. Call 911 if you need to use naloxone because this is a medical emergency.
- Keep opioid medications like Lortab (hydrocodone / acetaminophen) out of reach from children, pets, and visitors. Safely get rid of your opioid medication through a drug take-back option if you don't need to take it anymore. This lessens the risk for accidental overdose and medication misuse.
Lortab (hydrocodone / acetaminophen) dosage
The average cost for 90 tablets of 5mg/325mg of Lortab (hydrocodone / acetaminophen) is $16.64 with a free GoodRx coupon. This is 85.39% off the average retail price of $113.89.
Interactions between Lortab (hydrocodone / acetaminophen) and other drugs
Lortab (hydrocodone / acetaminophen) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Lortab (hydrocodone / acetaminophen). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Nalmefene
- Naltrexone
- Safinamide
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Acepromazine
- Alfentanil
- Almotriptan
- Alprazolam
- Amifampridine
- Amineptine
- Amiodarone
- Amitriptyline
- Amitriptylinoxide
- Amobarbital
- Amoxapine
- Amphetamine
- Amprenavir
- Anileridine
- Aprepitant
- Aripiprazole
- Armodafinil
- Asenapine
- Atazanavir
- Baclofen
- Benperidol
- Benzphetamine
- Boceprevir
- Bosentan
- Bromazepam
- Bromopride
- Brompheniramine
- Buprenorphine
- Buspirone
- Butabarbital
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Carbamazepine
- Carbinoxamine
- Carisoprodol
- Carphenazine
- Ceritinib
- Cetirizine
- Chloral Hydrate
- Chlordiazepoxide
- Chlorpheniramine
- Chlorpromazine
- Chlorzoxazone
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clobazam
- Clomipramine
- Clonazepam
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Conivaptan
- Crizotinib
- Cyclobenzaprine
- Cyclosporine
- Darunavir
- Dasabuvir
- Delavirdine
- Desipramine
- Desmopressin
- Desvenlafaxine
- Dexamethasone
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan
- Dezocine
- Diazepam
- Dibenzepin
- Dichloralphenazone
- Difenoxin
- Dihydrocodeine
- Diltiazem
- Diphenhydramine
- Diphenoxylate
- Dolasetron
- Donepezil
- Doxepin
- Doxylamine
- Dronedarone
- Droperidol
- Duloxetine
- Efavirenz
- Eletriptan
- Enflurane
- Enzalutamide
- Erythromycin
- Escitalopram
- Esketamine
- Eslicarbazepine Acetate
- Estazolam
- Eszopiclone
- Ethchlorvynol
- Ethopropazine
- Ethylmorphine
- Etravirine
- Fenfluramine
- Fentanyl
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluphenazine
- Flurazepam
- Fluspirilene
- Fluvoxamine
- Fosamprenavir
- Fosaprepitant
- Fosnetupitant
- Fosphenytoin
- Fospropofol
- Frovatriptan
- Furazolidone
- Gabapentin
- Gabapentin Enacarbil
- Granisetron
- Halazepam
- Haloperidol
- Halothane
- Hexobarbital
- Hydromorphone
- Hydroxytryptophan
- Hydroxyzine
- Idelalisib
- Imatinib
- Imipramine
- Indinavir
- Iproniazid
- Isocarboxazid
- Isoflurane
- Isoniazid
- Itraconazole
- Ivacaftor
- Ketamine
- Ketazolam
- Ketobemidone
- Ketoconazole
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomilnacipran
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lithium
- Lofepramine
- Lofexidine
- Lomitapide
- Lopinavir
- Lorazepam
- Lorcaserin
- Loxapine
- Lumacaftor
- Magnesium Oxybate
- Meclizine
- Melitracen
- Melperone
- Meperidine
- Mephobarbital
- Meprobamate
- Meptazinol
- Mesoridazine
- Metaxalone
- Methadone
- Methamphetamine
- Methdilazine
- Methocarbamol
- Methohexital
- Methotrimeprazine
- Methylene Blue
- Metoclopramide
- Mibefradil
- Midazolam
- Mifepristone
- Milnacipran
- Mirtazapine
- Mitotane
- Moclobemide
- Modafinil
- Molindone
- Moricizine
- Morphine
- Morphine Sulfate Liposome
- Nafcillin
- Nalbuphine
- Naratriptan
- Nefazodone
- Nelfinavir
- Netupitant
- Nevirapine
- Nialamide
- Nicomorphine
- Nilotinib
- Nitrazepam
- Nitrous Oxide
- Nortriptyline
- Olanzapine
- Ombitasvir
- Ondansetron
- Opipramol
- Opium
- Opium Alkaloids
- Orphenadrine
- Oxazepam
- Oxcarbazepine
- Oxycodone
- Oxymorphone
- Ozanimod
- Palbociclib
- Palonosetron
- Papaveretum
- Paregoric
- Paritaprevir
- Paroxetine
- Pentazocine
- Pentobarbital
- Perampanel
- Perazine
- Periciazine
- Perphenazine
- Phenelzine
- Phenobarbital
- Phenytoin
- Piperacetazine
- Pipotiazine
- Piritramide
- Pixantrone
- Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate
- Posaconazole
- Potassium Oxybate
- Prazepam
- Prednisone
- Pregabalin
- Primidone
- Procarbazine
- Prochlorperazine
- Promazine
- Promethazine
- Propofol
- Protriptyline
- Quazepam
- Quetiapine
- Ramelteon
- Ranitidine
- Ranolazine
- Rasagiline
- Remifentanil
- Remimazolam
- Remoxipride
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Rizatriptan
- Saquinavir
- Scopolamine
- Secobarbital
- Selegiline
- Sertindole
- Sertraline
- Sibutramine
- Sodium Oxybate
- St John's Wort
- Sufentanil
- Sulpiride
- Sumatriptan
- Suvorexant
- Tapentadol
- Telaprevir
- Telithromycin
- Temazepam
- Thiethylperazine
- Thiopental
- Thiopropazate
- Thioridazine
- Tianeptine
- Tilidine
- Tizanidine
- Tolonium Chloride
- Topiramate
- Tramadol
- Tranylcypromine
- Trazodone
- Triazolam
- Trifluoperazine
- Trifluperidol
- Triflupromazine
- Trimeprazine
- Trimipramine
- Tryptophan
- Venlafaxine
- Verapamil
- Vilazodone
- Voriconazole
- Vortioxetine
- Zaleplon
- Ziprasidone
- Zolmitriptan
- Zolpidem
- Zopiclone
- Zotepine
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acenocoumarol
- Carbamazepine
- Fosphenytoin
- Lixisenatide
- Phenytoin
- Warfarin
- Zidovudine
How much does Lortab (hydrocodone / acetaminophen) cost?
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Lortab (hydrocodone / acetaminophen) (generic)
$14.04
Lortab (hydrocodone / acetaminophen) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Lortab (hydrocodone / acetaminophen) will not be safe for you to take.
- Severely slowed breathing (respiratory depression)
- Severe asthma
- Medical conditions that cause blockage of the stomach passageway
- Allergy to hydrocodone or acetaminophen
What are alternatives to Lortab (hydrocodone / acetaminophen)?
There are a number of medications that your doctor can prescribe in place of Lortab (hydrocodone / acetaminophen). Compare a few possible alternatives below.
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Lortab (hydrocodone / acetaminophen) images
