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Lipfendra

enlicitide
Used for High Cholesterol

Lipfendra (enlicitide) is an oral PCSK9 inhibitor that helps lower cholesterol in adults. It works best with a heart-healthy diet and regular exercise. Lipfendra (enlicitide) comes as a tablet that you take by mouth once every morning on an empty stomach. Side effects can include diarrhea and dizziness.

Reviewed by:
reviewerCydnee Ng, PharmD
Last reviewed on July 22, 2026
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What is Lipfendra (enlicitide)?

What is Lipfendra (enlicitide) used for?

How Lipfendra (enlicitide) works

Lipfendra (enlicitide) is a PCSK9 inhibitor. It works by blocking a protein called PCSK9. This protein normally makes it harder for your liver to remove low-density lipoprotein (LDL), or "bad" cholesterol, from your blood.

By blocking PCSK9, Lipfendra (enlicitide) helps your liver remove more LDL cholesterol. This helps lower your cholesterol levels.

When does Lipfendra (enlicitide) start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
Full effect
MONTHS

Drug facts

Common BrandsLipfendra
Drug ClassPCSK9 inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Side effects of Lipfendra (enlicitide)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea
  • Dizziness

Source: Prescribing information

The following Lipfendra (enlicitide) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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Pros and cons of Lipfendra (enlicitide)

Pros

Cons

  • Must take on an empty stomach every morning
  • Must wait at least 30 minutes before eating or drinking after taking
  • Only approved for adults
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Pharmacist tips for Lipfendra (enlicitide)

pharmacist
  • Take Lipfendra (enlicitide) every morning on an empty stomach with water, black coffee, or plain tea. Wait at least 30 minutes before eating or drinking anything else. Making this part of your morning routine can help you remember to take the medication.
  • Swallow Lipfendra (enlicitide) whole. Don't cut the tablet in half, crush it, or chew it. This helps make sure the medication works as it should. If you have trouble swallowing the tablet, talk to your prescriber about your options.
  • If you miss a Lipfendra (enlicitide) dose, take it as soon as you remember. Be sure you have at least 30 minutes before eating or drinking anything (besides water, black coffee, or plain tea). Don't take two doses on the same day to make up for a missed dose.
  • Keep taking Lipfendra (enlicitide) even if you feel well. High cholesterol usually doesn't cause symptoms, so you might not notice that the medication is working. Taking it every day can help make sure it works the best it can for you.
  • Get your cholesterol checked when your prescriber tells you to. These blood tests help show how well Lipfendra (enlicitide) lowers your cholesterol. The results help your prescriber decide if your treatment needs to change.
  • Store Lipfendra (enlicitide) at room temperature in its original bottle. Keep the drying packet (desiccant) in the bottle and keep the bottle cap tightly closed. This helps protect the medication from moisture.
  • If you become pregnant while taking Lipfendra (enlicitide): Stop taking the medication right away and tell your prescriber. Lipfendra (enlicitide) might harm an unborn baby based on the way it works. Your prescriber can help find a safe treatment plan.
  • If you plan to breastfeed: Talk to your prescriber. It's not known if Lipfendra (enlicitide) passes into breast milk. Your prescriber can talk to you about the risks and benefits of breastfeeding while taking this medication. If needed, ask your prescriber or a lactation consultant about safe feeding options.
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Lipfendra (enlicitide) dosage

The average cost for 30 tablets of 20mg of Lipfendra (enlicitide) is $308.65 with a free GoodRx coupon.
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DosageQuantityPrice as low asPrice per unit
20mg30 tablets$308.65$10.29

Typical dosage for Lipfendra (enlicitide)

The typical dose is 20 mg by mouth once every morning on an empty stomach.

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How much does Lipfendra (enlicitide) cost?

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Lipfendra (brand)
GoodRx lowest price

$308.65

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What are alternatives to Lipfendra (enlicitide)?

There are a number of medications that your doctor can prescribe in place of Lipfendra (enlicitide). Compare a few possible alternatives below.
Lipfendra (enlicitide)
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References

Best studies we found

Brumit, M. L. (2014). What is heterozygous familial hypercholesterolemia? Family Heart Foundation.

Henry, M. L., et al. (2024). Specialty corner: Lipid management in pregnancy and lactation. National Lipid Association.

Merck Sharp & Dohme. (2026). LIPFENDRA (enlicitide) tablets, for oral use [package insert].

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.