What is Lexiscan?

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• Overview
• Proper Use
• Before Using
• Allergies
• Pediatric
• Geriatric
• Breast Feeding
• Drug Interactions
• Other Interactions
• Other Medical Problems
• Precautions

OverviewTOP

Regadenoson injection is used as a pharmacologic stress agent for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress. This medicine works by dilating the arteries of the heart and increase blood flow to help identify coronary artery disease.

This medicine is to be given only by or under the direct supervision of a doctor.

Proper UseTOP

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Appropriate studies have not been performed on the relationship of age to the effects of regadenoson injection in the pediatric population. Safety and efficacy have not been established.

GeriatricTOP

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of regadenoson injection in the elderly. However, elderly patients are more likely to have low blood pressure, which may require caution in patients receiving regadenoson injection.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aminophylline
• Bamifylline
• Dimenhydrinate
• Dyphylline
• Pentoxifylline
• Theophylline

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina, unstable or
• Unstable heart or blood vessel problem (eg, cardiovascular instability)—Avoid use, as this drug may increase the risk for heart attack.

• Breathing problems or lung disease (eg, asthma, bronchoconstriction, COPD) or
• Heart rhythm problems (eg, atrial fibrillation, atrial flutter) or
• Hypertension (high blood pressure) or
• Hypotension (low blood pressure) or
• Seizures or
• Stroke, history of—Use with caution. May make these conditions worse.

• Heart block, second or third degree (type of abnormal heart rhythm), without a pacemaker or
• Sinus node dysfunction (type of abnormal heart rhythm), without a pacemaker—Should not be used in patients with these conditions, unless patients have a pacemaker that works.

• Heart or blood vessel disease (eg, coronary artery stenosis, ischemia, pericarditis) or
• Heart valve disease or
• Hypovolemia (low blood volume)—May increase risk for more serious side effects.

PrecautionsTOP

It is very important that your doctor check your progress very closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you start having a rash, itching, increased heart rate, lightheadedness or fainting, trouble breathing, trouble swallowing, swelling of your hands, face, mouth, or throat, or chest pain after you receive the medicine.

Heart attack, stroke, and death may occur after receiving this medicine. Make sure your doctor knows if you have any heart problems (eg, unstable angina or cardiovascular instability) before you have a heart stress test. Check with your doctor right away if you have chest pain or discomfort, nausea, pain or discomfort in arms, jaw, back or neck, sweating, or vomiting.

Make sure your doctor knows if you are using dipyridamole (Persantine®) before you receive this medicine. You may need to stop using dipyridamole for at least 2 days before the test, if possible.

Make sure your doctor knows if you are using aminophylline or theophylline (Theo-24®, Uniphyl®) before you receive this medicine. You may need to stop using aminophylline or theophylline for at least 12 hours before the test.

Do not take anything that contains caffeine for at least 12 hours before you receive this medicine. This includes medicines, foods, and beverages with caffeine, such as coffee, tea, and cola drinks.