The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Side effects for leflunomide:
- Diarrhea (up to 27%
- Headache (up to 13%)
- Nausea (up to 13%)
- Rash (up to 12%)
- Abnormal liver labs (up to 10%)
- Hair thinning or hair loss (up to 9%)
- High blood pressure (up to 9%)
Side effects for diclofenac gel:
- Redness, rash, itchiness of the skin (contact dermatitis, 4%)
Less Common Side Effects
Side effects for leflunomide:
- Weakness
- Back pain
- Stomach pain
Lefluniclo serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Stroke: tiredness, lightheadedness, blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
- Serious lung problems (interstitial lung disease): new or worsening cough, trouble catching your breath, fever
- Severe asthma attack: chest pain, cough, difficulty breathing, wheezing
- Heart attack: dizziness, tiredness, cold sweat, trouble breathing, chest pain or tightness, anxiety
- Heart failure: trouble breathing, tiredness, swelling in your body, sudden weight gain
- Serious liver problems: severe stomach pain, yellowing of the skin or whites of the eyes, nausea, vomiting, loss of appetite
- Stomach bleeding: vomiting blood, bloody or dark stools, severe stomach pain or discomfort
- Serious allergic or skin reaction: fever, body aches, cough, peeling skin, rash, trouble breathing, swelling of the face, painful blisters all over your body
- Serious infections: fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, chills, burning when you urinate, urinating more frequently
Source: DailyMed
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