The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Stomach problems, such as loss of appetite, stomach pain, nausea, vomiting, or diarrhea (17%)
- Total or partial loss of taste (12%)
- Protein in urine (6%)
- Rash (5%)
Less Common Side Effects
- Fever
- Lupus-like symptoms (muscle pain, feeling tired, rash)
- Hives
- Other skin problems (wrinkling, flaking)
- Mouth sores
- Ringing in the ears
- Vision changes
- Movement problems
- Anxiety
- Mood problems
- Low platelets or white blood cell counts
Penicillamine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Low white blood cells: getting fevers, sore throat, or chills too often or if they don’t go away
- Low platelets: bruising, bleeding
- Kidney damage: blood in your urine
Source: DailyMed
The following Penicillamine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
More common
joint pain
lesions on the face, neck, scalp, and/or trunk
swollen and/or painful glands
ulcers, sores, or white spots on lips or in mouth
Less common
Bloody or cloudy urine
shortness of breath, troubled breathing, tightness in chest, or wheezing
sore throat and fever with or without chills
swelling of face, feet, or lower legs
unusual bleeding or bruising
unusual tiredness or weakness
Rare
Abdominal or stomach pain (severe)
blisters on skin
bloody or black, tarry stools
coughing or hoarseness
dark urine
difficulty in breathing, chewing, talking, or swallowing
eye pain, blurred or double vision, or any change in vision
general feeling of discomfort or illness or weakness
lower back or side pain
muscle weakness
painful or difficult urination
pale stools
pinpoint red spots on skin
redness, tenderness, itching, burning, or peeling of skin
red or irritated eyes
red, thick, or scaly skin
ringing or buzzing in the ears
spitting blood
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Other Penicillamine articles
Why trust our experts?


