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Penicillamine

Penicillamine Side Effects

Kristianne Hannemann, PharmDCydnee Ng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Cydnee Ng, PharmD
Last reviewed on June 13, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach problems, such as loss of appetite, stomach pain, nausea, vomiting, or diarrhea (17%)
  • Total or partial loss of taste (12%)
  • Protein in urine (6%)
  • Rash (5%)

Less Common Side Effects

  • Fever
  • Lupus-like symptoms (muscle pain, feeling tired, rash)
  • Hives
  • Other skin problems (wrinkling, flaking)
  • Mouth sores
  • Ringing in the ears
  • Vision changes
  • Movement problems
  • Anxiety
  • Mood problems
  • Low platelets or white blood cell counts

Penicillamine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Low white blood cells: getting fevers, sore throat, or chills too often or if they don’t go away
  • Low platelets: bruising, bleeding
  • Kidney damage: blood in your urine
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Source: DailyMed

The following Penicillamine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Fever

joint pain

lesions on the face, neck, scalp, and/or trunk

skin rash, hives, or itching

swollen and/or painful glands

ulcers, sores, or white spots on lips or in mouth

Less common

Bloody or cloudy urine

shortness of breath, troubled breathing, tightness in chest, or wheezing

sore throat and fever with or without chills

swelling of face, feet, or lower legs

unusual bleeding or bruising

unusual tiredness or weakness

weight gain

Rare

Abdominal or stomach pain (severe)

blisters on skin

bloody or black, tarry stools

chest pain

coughing or hoarseness

dark urine

difficulty in breathing, chewing, talking, or swallowing

eye pain, blurred or double vision, or any change in vision

general feeling of discomfort or illness or weakness

lower back or side pain

muscle weakness

painful or difficult urination

pale stools

pinpoint red spots on skin

redness, tenderness, itching, burning, or peeling of skin

red or irritated eyes

red, thick, or scaly skin

ringing or buzzing in the ears

spitting blood

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

lessening or loss of sense of taste

loss of appetite

nausea or vomiting

stomach pain (mild)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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