Penicillamine Dosage

This medication is available as tablets and capsules. Take Penicillamine on an empty stomach and separate from other foods or medications that contain certain minerals. See Pharmacist Tips for more details on how to take Penicillamine.

Wilson's disease

• Adults: Typically, your dose will depend on how much copper is in your urine and blood. The dose is usually between 750 mg and 1,500 mg taken by mouth every day, split into two doses. If you aren’t tolerating higher doses, you might start with 250 mg per day, and then your provider can raise your dose slowly to avoid side effects.
• Children: Ask your child’s provider about the appropriate dose your child should take.

Cystinuria

• Adults: The typical dose is 1 to 4 grams taken by mouth every day, split into four doses throughout the day. You might start at a dose of 250 mg every day. Then, your provider can raise the dose slowly. This helps better control how well the medication works and avoid side effects.
• Children: The dose will depend on your child’s body weight. The typical dose is 30 mg/kg of weight taken by mouth every day, split into four doses throughout the day.

Rheumatoid arthritis

• Adults: The typical starting dose is 125 mg or 250 mg taken by mouth every day. Depending on how you respond to the medication, your provider might slowly raise your dose to a typical maintenance dose range of 500 mg to 700 mg per day. Dosages of more than 500 mg per day should be split into multiple doses throughout the day.
• Children: It isn’t known if Penicillamine works well in children with juvenile RA. Ask your child’s provider about alternative medications.