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Jublia

efinaconazole
Used for Nail Fungus
Used for Nail Fungus

Jublia (efinaconazole) is a prescription antifungal medication used to treat toenail fungus in people 6 years and older. It comes as a topical solution that you apply once a day directly to the affected toenail and the skin around it. Treatment usually lasts for almost a year. Common side effects include ingrown toenail and redness, itching, or irritation at the application site.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Daisy Chau, PharmD
Last reviewed on September 16, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsDosageCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Jublia (efinaconazole)?

What is Jublia (efinaconazole) used for?

How Jublia (efinaconazole) works

Jublia (efinaconazole) is an azole antifungal. It works by blocking the fungus from making its protective outer layer. Without this layer, the fungus can’t grow or survive.

When does Jublia (efinaconazole) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsJublia
Drug ClassAntifungal
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Jublia (efinaconazole) essentials

Health: Jublia: close up toenail fungus 1266811992

Jublia: Topical Treatment for Nail Fungus

Written by Ross Phan, PharmD, BCACP, BCGP, BCPS
Pharmacy: closeup pharmacy prescription 1480000105

How Much Is Jublia Without Insurance?

Written by Maggie Aime, MSN, RN
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Avg retail price
$923.74(save 19.23%)
GoodRx discount
$746.13
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What are the side effects of Jublia (efinaconazole)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Ingrown toenail (2%)
  • Skin irritation around the application site (2%)
  • Blisters around the application site (2%)

Other Side Effects

  • Pain around the application site

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Ingrown nails
  • Mild skin irritation, redness, or dryness
pros-and-cons

Pros and cons of Jublia (efinaconazole)

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Pros

Used just once a day

Applied directly to the toenail(s)

Fewer side effects compared to oral antifungals

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Cons

Doesn't work as well as other antifungals

Can be messy to apply

Treatment lasts almost a year

pharmacist-tips

Pharmacist tips for Jublia (efinaconazole)

pharmacist

  • Apply Jublia (efinaconazole) to your toenail and the surrounding skin only. Don't take it by mouth, use it in your eyes, or place it inside the vagina.

    • Use Jublia (efinaconazole) every day for 48 weeks (about 11 months). Don't stop early, even if your toenails look better, unless your prescriber tells you so. Stopping too soon can make the infection come back stronger.

      • Avoid nail polish while using Jublia (efinaconazole). It's unclear whether it will cause this medication to not work as well. Wait until your infection is gone and your nails healed before applying nail polish again.

        • Jublia (efinaconazole) can cause some redness, itching, and swelling at the application site. Let your prescriber know if these side effects don't go away.

          • Store Jublia (efinaconazole) at room temperature in its original bottle. Keep it away from heat and open flames because the solution is flammable.

            How to use Jublia (efinaconazole):

            • Before using Jublia (efinaconazole), wash your feet and toes with soap and water and let them dry for at least 10 minutes.

              • Use the brush applicator to apply Jublia (efinaconazole) to the affected toenail(s). Cover the whole nail, the cuticle, the skin around the nail, and the skin under the nail tip.

                • Let Jublia (efinaconazole) dry fully before putting on socks or shoes. If you're treating your big toenail, apply a second coat shortly after.

                  • Wash your hands after using Jublia (efinaconazole). Even with the brush, it’s easy to touch the infected nail by accident and spread the fungus to other parts of your body or to other people.

                    More on Jublia (efinaconazole) tips

                    jublia: pharmacy tips jublia

                    How to Apply Jublia, Plus 4 More Tips for Using This Nail Fungus Treatment

                    Written by Tegan Smedley, PharmD, BCPS, APh
                    faqs

                    Frequently asked questions about Jublia (efinaconazole)

                    Does Jublia (efinaconazole) really work?
                    It can. Studies show that after about 11 months of treatment, Jublia (efinaconazole) completely cleared toenail fungus in about 15-18% of people, compared to only 3-6% of people who used placebo. Talk with your primary care provider if you have questions about how well this medication might work for you.
                    How long does it take for Jublia (efinaconazole) to work?
                    In studies, people started to see improvement within 3 months of using Jublia (efinaconazole). But it can take up to a year to completely clear the infection. The reason why it takes so long is because the infected nail must grow out and be replaced by healthy nail. Because this process is slow, you need to use Jublia (efinaconazole) for 48 weeks.
                    Does Jublia (efinaconazole) cause liver damage?
                    No, Jublia (efinaconazole) doesn't cause liver damage. It's an azole antifungal, and this class of medications can sometimes cause liver problems when taken by mouth or given by injection. But since Jublia (efinaconazole) is applied directly to the nail, only a tiny amount of medication enters your body, so it doesn't harm the liver.
                    Is there a generic for Jublia (efinaconazole)?
                    No, Jublia (efinaconazole) is only available by brand name only.
                    Is Jublia (efinaconazole) over the counter?
                    No, Jublia (efinaconazole) is available by prescription only by a healthcare professional.
                    Can I use Jublia (efinaconazole) while breastfeeding?
                    It isn’t known if Jublia (efinaconazole) passes into breast milk. Since you only apply the solution to your toenail, very little of it gets into your body. This means the risk to your baby is likely very low. Still, you should talk with your prescriber before using Jublia (efinaconazole) while breastfeeding to make sure it’s safe for both of you.
                    Can Jublia (efinaconazole) be used with nail polish?
                    It’s best to avoid nail polish or other cosmetic nail products while you’re using Jublia (efinaconazole) since it's not clear if it will impact how well the medication works. Ask your prescriber what nail care options are ok to use while you’re receiving treatment.
                    Can Jublia (efinaconazole) be used on fingernails?
                    Jublia (efinaconazole) is only FDA approved to treat toenail fungus. It's usually not prescribed for fingernail fungus because it hasn't been well studied in people with this condition. One report suggests that it might help, but more research is needed. If you have a fungal infection on your fingernails, talk with your primary care provider about the best treatment.
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                    dosage

                    Jublia (efinaconazole) dosage forms

                    The average cost for 1 bottle of 4ml of 10% of Jublia (efinaconazole) is $746.13 with a free GoodRx coupon. This is 19.23% off the average retail price of $923.74.
                    bottle of topical solution
                    Bottle of topical solution
                    DosageQuantityPrice as low asPrice per unit
                    4ml of 10%1 bottle$746.13$746.13
                    8ml of 10%1 bottle$1477.72$1477.72

                    Typical dosing for Jublia (efinaconazole)

                    Apply to the affected toenail(s) once a day for 48 weeks (about 11 months) using the brush applicator. Make sure to apply enough of the solution to cover the entire toenail, the skin under it, and the skin around it.

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                    How much does Jublia (efinaconazole) cost?

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                    alternatives

                    What are alternatives to Jublia (efinaconazole)?

                    There are a number of medications that your doctor can prescribe in place of Jublia (efinaconazole). Compare a few possible alternatives below.
                    Jublia (efinaconazole)
                    Used for:
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                    Ciclopirox
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                    • Yeast infections of the skin

                    • Seborrheic dermatitis of the scalp - shampoo and gel only

                    • Fungal nail infection - nail lacquer only

                    $23.25 Lowest GoodRx priceView Prices
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                    Jublia (efinaconazole) images

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                    This medicine is Yellow Bottle Of Topical Solution.yellow - JUBLIA 10% Topical Solution

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                    References

                    Best studies we found

                    Bausch Health US LLC. (2025). JUBLIA- efinaconazole solution [package insert]. DailyMed.

                    Drugs and Lactation Database (LactMed®) . (2018). Efinaconazole.

                    Elewski, B. E., et al. (2012). Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies. Journal of the American Academy of Dermatology.

                    View All References (2)

                    Jellinek, N. J., et al. (2015). Prognostic Factors for Complete Cure Following Treatment of Mild and Moderate Toenail Onychomycosis With Efinaconazole Topical Solution 10. Journal of Drugs in Dermatology.

                    Miller, R. C., et al. (2022). Treatment of Fingernail Onychomycosis with Efinaconazole 10% Solution in a Patient with Scleroderma: A Case Report. Skin Appendage Disorders.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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