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Imiquimod

Imiquimod Side Effects

Aileen Chu, PharmD, BCPSMichelle Nguyen, PharmD
Reviewed by Aileen Chu, PharmD, BCPS, Michelle Nguyen, PharmD
Last reviewed on April 3, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Skin reaction (33% total), including itching (20%), burning (6%), bleeding, stinging, and pain
  • Common cold symptoms (15%)
  • Sinus inflammation (7%)
  • Headache (5%)

Less Common Side Effects

  • Eczema
  • Skin cancer
  • Diarrhea
  • Vomiting
  • Back pain
  • Fatigue
  • Dizziness
  • Fever
  • Viral infection
  • Chills
  • Atrial fibrillation (irregular heartbeat)
  • Urinary tract infection
  • Hair loss

Imiquimod serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe skin reactions
  • Difficulty urinating due to genital swelling
When do Imiquimod possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Itching, burning, and other skin reactions
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Imiquimod side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blisters on the skin

body aches or pain

chills

cough

difficulty with breathing

ear congestion

itching in the genital or other skin areas

loss of voice

open sores or scabs on the skin

pain or tenderness around the eyes and cheekbones

redness of the skin (severe)

scaling

shortness of breath or troubled breathing

skin rash

sneezing

sore throat

stuffy or runny nose

tightness of the chest or wheezing

unusual tiredness or weakness

Less common

Abdominal or stomach pain

ankle, knee, or great toe joint pain

bladder pain

bloody or cloudy urine

blurred vision

chest pain

cold flu-like symptoms

difficult, burning, or painful urination

dizziness

fainting

fast or irregular heartbeat

frequent urge to urinate

hoarseness

joint stiffness or swelling

lower back or side pain

lump in the abdomen or stomach

nervousness

persistent non-healing sore

pink growth on the skin

pounding in the ears

reddish patch or irritated area

severe headache

shiny bump on the skin

slow or fast heartbeat

swollen, painful, or tender lymph glands in the neck, armpit, or groin

white, yellow or waxy scar-like area

Incidence not known

Blue lips and fingernails

convulsions

coughing that sometimes produces a pink frothy sputum

dilated neck veins

extreme fatigue

fast, irregular, or pounding heartbeat

headache

irregular breathing

nausea or vomiting

pain in the shoulders, arms, jaw, or neck

slurred speech

sudden and severe inability to speak

suicide

sweating

swelling of the face, fingers, feet, or lower legs

temporary blindness

weakness in the arm or leg on one side of the body

weight gain

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Confusion

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning or stinging of the skin (mild)

flaking of the skin

mild headache

pain, soreness, or tenderness of the skin (mild)

rash

redness of the skin (mild)

swelling at place of application

Less common

Back pain

lightening of the treated skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Aileen Chu, PharmD, has over 8 years of experience working as a clinical pharmacist in the emergency department. Chu is also a pharmacotherapeutics instructor at Point Loma Nazarene University.
Michelle Nguyen, PharmD, has been a clinical pharmacist for 6 years (and counting). She has a diverse skill set within managed care pharmacy, specifically in the settings of a medical group, pharmacy benefit manager (PBM), and health plan.

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