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Hydrocodone / Homatropine Coupon - Hydrocodone / Homatropine 473ml of 5mg/1.5mg/5ml syrup

hydrocodone / homatropine

Generic Hydromet
Used for Cough
Used for Cough

Hydromet is a prescription cough medication that some veterinarians prescribe off-label to help dogs with their cough. It’s also known by another brand name called Hycodan. This medication combines hydrocodone (an opioid) and homatropine (an anticholinergic). It comes as a syrup or tablet and is given by mouth. The dosage for dogs depends on their weight and is usually given every 6 to 12 hours. Hydromet is a controlled substance, meaning it has a high risk of misuse and is tightly regulated.

Reviewed by:
reviewer
Elizabeth Carman, PharmD, FSVHP
reviewer
Daisy Chau, PharmD
Last reviewed on June 13, 2025
BasicsWarningsSide effectsPros & consPharmacist tipsFAQsDosageInteractionsCostContraindicationsImagesPricesMedicare
Hydromet is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
Paws

For pets

Hydromet can be prescribed or used off-label by a licensed veterinarian for pets. Medications prescribed for pets aren't intended for human use.

Explore pet medicationsView information for human use
basics-icon

What is Hydromet for pets?

What is Hydromet for pets used for?

How Hydromet for pets works

Hydromet is a combination of two medications:

  • Hydrocodone is an opioid that works by calming the part of your dog’s brain that causes coughing.

  • Homatropine is an anticholinergic that’s added to help prevent misuse by people and make sure the medication is used safely.

Drug Facts

Common BrandsHydromet
Drug ClassOpioid / Anticholinergic
Controlled Substance ClassificationSchedule II
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the risks and warnings for Hydromet for pets?

Hydromet can cause some serious health issues. This risk might be even higher for certain pets. If this worries you, talk to your veterinarian about other options.

risk-warning

Risk for withdrawal if suddenly stopped

  • Risk factors: Taking Hydromet for a long time

    Check with your veterinarian about how long your dog should take Hydromet. Dogs that take this medication for a long time can become dependent on it. If you stop giving it suddenly, your dog might have withdrawal symptoms such behavioral changes, shaking, diarrhea, or trouble moving. Your vet can help you safely stop Hydromet to lower the risk of these problems.

    risk-warning

    Dangerously slow breathing

    • Risk factors: Older age | Lung problems | Taking Hydromet with other medications that slow breathing | High doses of Hydromet

      Hydromet can slow down your dog’s breathing, which can be life threatening. The risk is higher in older dogs, dogs with lung problems, dogs taking other medications that slow breathing (like opioids or benzodiazepines), or when taking high doses. If you notice your dog’s breathing has slowed, contact a veterinarian right away or call a pet poison helpline.

      risk-warning

      Risk for overdose

      • Risk factors: High doses of Hydromet

        Don’t give your dog more Hydromet than your veterinarian has prescribed. Too much hydrocodone from the medication can cause an overdose, which might lead to death. Signs of overdose include trouble breathing, extreme sleepiness, weakness, balance problems, trouble standing, or a blank stare. Contact a veterinarian or pet poison helpline right away if you think your dog has had too much of this medication.

        risk-warning

        Risk for constipation

        • Risk factors: Taking Hydromet for a long time | Diarrhea caused by a harmful substance

          Hydromet can slow down your dog’s gut, which can lead to constipation. The risk is higher if your dog takes the medication for a long time. It’s also important not to give this medication to your dog if they have diarrhea caused by something harmful, like chocolate. That’s because this medication can keep the toxin in their body longer and cause more serious problems. Make sure your dog drinks plenty of fresh water and eats regularly to help prevent constipation. Talk to your vet if the constipation doesn’t go away or gets worse.

          basics-icon

          What are the side effects of Hydromet for pets?

          The following side effects might get better over time as your pet gets used to the medication. Let your veterinarian know immediately if your pet continues to experience these symptoms or if they worsen over time.

          Common Side Effects

          Other Side Effects

          • Constipation
          • Itching
          • Reduced appetite
          • Vomiting

          Serious Side Effects

          Contact your veterinarian immediately if your pet experiences any of the following.
          • Dangerously slow breathing: trouble breathing, labored breathing
          • Overdose (giving too much to your pet): difficulty breathing, excessive sleepiness, balance problems, difficulty standing, blank stare, weakness

          The following side effects have also been reported

          Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

          Check with your doctor immediately if any of the following side effects occur:

          Less common

          Bladder pain

          bloating or swelling of the face, arms, hands, lower legs, or feet

          bloody or cloudy urine

          body aches or pain

          chills

          cough

          depression

          difficult or labored breathing

          difficult, burning, or painful urination

          ear congestion

          fear or nervousness

          fever

          frequent urge to urinate

          headache

          loss of voice

          lower back or side pain

          nasal congestion

          rapid weight gain

          runny nose

          sneezing

          sore throat

          tightness in the chest

          tingling of the hands or feet

          unusual tiredness or weakness

          unusual weight gain or loss

          Incidence not known

          Agitation

          darkening of the skin

          diarrhea

          difficulty swallowing

          fast heartbeat

          hives, itching, skin rash

          loss of appetite

          mental depression

          nausea

          overactive reflexes

          poor coordination

          puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

          restlessness

          shivering

          talking or acting with excitement you cannot control

          trembling or shaking

          twitching

          vomiting

          Get emergency help immediately if any of the following symptoms of overdose occur:

          Symptoms of overdose

          Blue lips and fingernails

          blurred vision

          change in consciousness

          chest pain or discomfort

          cold and clammy skin

          confusion

          constricted pupil (black part of the eye)

          coughing that sometimes produces a pink frothy sputum

          decreased awareness or responsiveness

          dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

          increased sweating

          irregular, fast or slow, or shallow breathing

          lightheadedness, dizziness, or fainting

          pale skin

          sleepiness or unusual drowsiness

          slow or irregular heartbeat

          weak muscle tone

          Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

          More common

          Difficulty having a bowel movement

          Less common

          Back pain

          dry mouth

          heartburn

          muscle spasms

          stomach pain or discomfort

          Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

          Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

          pros-and-cons

          Pros and cons of Hydromet for pets

          thumbs-up

          Pros

          Works within 1 to 2 hours

          Can be given as needed for cough

          Comes as a liquid and a tablet

          thumbs-down

          Cons

          Sleepiness is a common side effect

          Doesn’t treat the cause of your dog’s cough

          Is a controlled substance

          pharmacist-tips

          Pharmacist tips for Hydromet for pets

          pharmacist

          • You can give Hydromet to your dog with or without food. If your dog throws up or seems sick after taking it on an empty stomach, give the next dose with a small meal or treat.

            • Hydromet is a schedule II controlled substance, which means it can’t be refilled. You’ll need a new prescription from your vet every time your dog needs this medication. A photo ID, like a driver’s license, is required to pick it up at the pharmacy.

              • Hydromet is a human medication that’s prescribed off-label for dogs. People can misuse or become addicted to it, so it's important to keep the medication stored away and locked up.

                More tips for the liquid form:

                • Don’t use household spoons to measure the dose of Hydromet because they can give the wrong amount. Use a medication syringe or dosing cup from the pharmacy to make sure your dog gets the right dose.

                  • You can store liquid Hydromet at room temperature. Because it’s a controlled substance, keep it in a safe place.

                    faqs

                    Frequently asked questions about Hydromet for pets

                    Can a dog take Hydromet for pain?
                    No.Hydromet is usually prescribed to treat cough in dogs. If your dog is in pain, it's important to talk to your veterinarian about the best way to manage it safely.
                    Is Hydromet safe for dogs?
                    Hydromet is generally safe for most dogs when prescribed by a veterinarian. Some dogs might become very sleepy when taking it. Senior dogs or those with head injuries might be more sensitive to side effects. It might also not be safe for dogs with thyroid, heart, lungs, kidneys, or adrenal gland problems. Always follow your vet’s instructions closely and contact them if your dog shows any unusual symptoms.
                    What are the most common side effects of Hydromet in dogs?
                    The most common side effect of Hydromet is sleepiness. Other possible side effects include constipation, itching, reduced appetite, and vomiting. It’s a good idea to let your vet know if your dog has any of these side effects since they can provide guidance on how to manage them.
                    How long does Hydromet take to work on a dog?
                    Hydromet starts to work within 1 to 2 hours. You should notice your dog’s cough improving around that time. If the cough doesn’t get better after a full day of using the medication, contact your veterinarian.
                    Will Hydromet make my dog sleepy?
                    Yes, Hydromet will likely make your dog sleepy. If your dog seems overly sleepy, hard to wake up, or has trouble breathing, the dose might be too high. Contact a veterinarian or a pet poison helpline right away if you notice any of these signs.
                    Should Hydromet for dogs be taken with food?
                    It’s okay to give Hydromet to your dog with or without food. But if your dog feels sick after a dose, try giving the next one with food. If your dog still gets sick, talk to your veterinarian.
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                    dosage

                    Hydromet dosage forms

                    ml of syrup
                    Ml of syrup
                    DosageQuantityPrice as low asPrice per unit
                    5mg/1.5mg/5ml120 ml$13.44$0.11

                    Typical dosing for Hydromet for pets

                    The dose is based on your dog’s weight.

                    The typical dose is 0.25 mg/kg of hydrocodone by mouth every 6 to 12 hours.

                    interactions

                    Interactions between Hydromet and other drugs for pets

                    Hydromet might interact with certain medications or supplements. Always let your veterinarian know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that your pet is currently taking. The list below does not include all possible drug interactions with Hydromet. Please note that only the generic name of each medication is listed below.

                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                    How much does Hydromet cost?

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                    Hydromet (brand)
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                    contraindications-icon

                    Hydromet contraindications for pets

                    Contraindications are specific health conditions or situations in which a pet should not take a medication due to safety concerns. If your pet has any of the following conditions or if any of the following apply to your pet, let your veterinarian know because Hydromet will not be safe for your pet to take.

                    • Allergic to opioids

                    • Allergic to atropine or medications like it

                    • Have diarrhea caused by a toxic substance

                    images

                    Hydromet images

                    red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5ml Solution
                    This medicine is Red Syrup.red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5ml Solution
                    red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution
                    This medicine is Red Syrup.red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution
                    red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution
                    This medicine is Red Syrup.red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution

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