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Herceptin

Herceptin Side Effects

Jenny Zhang, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Jenny Zhang, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on October 5, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Body and joint pain (up to 47%)
  • Weakness (up to 42%)
  • Fever (up to 36%)
  • Nausea (to up 33%)
  • Chills (up to 32%)
  • Headache (up to 26%)
  • Cough (up to 26%)
  • Diarrhea (up to 25%)
  • Vomiting (up to 23%)
  • Infection (up to 20%)

*Side effect percentages listed for [[EDITOR|DRUG_DISPLAY_NAME]] when used by itself.

Less Common Side Effects

  • Dizziness
  • Sore throat or runny nose
  • Loss of appetite
  • Trouble sleeping
  • Swelling of the legs or arms
  • Rash

Herceptin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Heart problems: chest pain, racing heartbeat, shortness of breath that usually worsens with activity or while lying flat, swelling of your legs or feet, sudden weight gain, fatigue
  • Serious infusion reactions: trouble breathing, itching or hives, flushing, swelling, chest pain, fast heartbeat, dizziness, fainting
  • Lung problems: shortness of breath, trouble breathing
  • Serious infections (when receiving in combination with chemotherapy): repeated fevers, chills, sweating, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination

Source: DailyMed

The following Herceptin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Dizziness

fever or chills

headache

muscle aches

nausea or vomiting

skin rash

sore throat

stuffy or runny nose

unusual tiredness or weakness

Less common

Bloody nose

cough

diarrhea

difficult or labored breathing

ear congestion or pain

fast or irregular heartbeat

general feeling of discomfort or illness

head congestion

hoarseness or other voice changes

increased cough

joint pain

loss of appetite

nasal congestion

pain or tenderness around the eyes and cheekbones

shivering

sneezing

sweating

swelling of the feet or lower legs

tightness in the chest

trouble with sleeping

vomiting

Rare

Blue lips and fingernails

blurred vision

chest pain

confusion

cough or hoarseness, accompanied by fever or chills

faintness or lightheadedness when suddenly getting up from a lying or sitting position

itching

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, feet, or sex organs

lower back or side pain, accompanied by fever or chills

painful or difficult urination, accompanied by fever or chills

pale skin

redness of the skin

Incidence not known

Black, tarry stools

bloody or cloudy urine

sores, ulcers, or white spots in the mouth

unusual bleeding or bruising

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty in moving

metallic taste in the tongue

muscle pain or stiffness

pain

weight loss

Less common

Numbness or tingling of the hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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