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Perjeta

Perjeta Side Effects

Lauren Morton, PharmD, BCPSCydnee Ng, PharmD
Reviewed by Lauren Morton, PharmD, BCPS, Cydnee Ng, PharmD
Last reviewed on November 29, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

The following side effects happened in people who took [[EDITOR|DRUG_DISPLAY_NAME]] together with Herceptin (trastuzumab) with or without chemotherapy. Some side effects (e.g., mouth sores, hair loss) might be related more to the chemotherapy treatment than [[EDITOR|DRUG_DISPLAY_NAME]].

  • Diarrhea (up to 72%)
  • Nausea (up to 71%)
  • Hair loss (up to 67%)
  • Fatigue (up to 58%)
  • Nerve problems in hands or feet (tingling or numbing sensation; up to 42%)
  • Weakness or lack of energy (up to 41%)
  • Vomiting (up to 40%)
  • Constipation (up to 38%)
  • Anemia (up to 38%)
  • Mucosal inflammation (mouth sores, mouth or gut inflammation; up to 37%)
  • Rash (up to 34%)
  • Muscle pain (up to 33%)
  • Headache (up to 30%)

Less Common Side Effects

  • Lower appetite
  • Changes in how things taste
  • Indigestion
  • Cough
  • Nose bleed
  • Dry skin
  • Fever
  • Dizziness
  • Joint pain
  • Swelling of the arms and legs
  • Changes in the appearance of your nails
  • Trouble sleeping

Perjeta serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Infusion-related or allergic reactions: fever, chills, dizziness, nausea, headache, sweating, rash, swelling of the face or throat, trouble breathing
  • Heart problems: shortness of breath; dry cough; swelling of legs, arms, or face; irregular heartbeats; dizziness; sudden weight gain

Source: DailyMed

The following Perjeta side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

burning, numbness, tingling, or painful sensations

chills

cough

fast heartbeat

fever

hives, itching, or rash

hoarseness

joint pain, stiffness, or swelling

lower back or side pain

painful or difficult urination

pale skin

redness of the skin

sore throat

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

troubled breathing or swallowing

ulcers, sores, or white spots in the mouth

unsteadiness or awkwardness

unusual bleeding or bruising

unusual tiredness or weakness

weakness in the arms, hands, legs, or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain

change in taste

cracked lips

decreased appetite

diarrhea

dizziness

dry skin

ear congestion

hair loss or thinning of the hair

headache

loosening of the fingernails

loss of taste

loss of voice

nasal congestion

nausea

redness or soreness around the fingernails

runny nose

sneezing

vomiting

watering of the eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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