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Fulvestrant

Fulvestrant Side Effects

Jenny Zhang, PharmD, BCOPConnie Zheng, PharmD
Reviewed by Jenny Zhang, PharmD, BCOP, Connie Zheng, PharmD
Last reviewed on October 20, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Joint pain (8-17%)
  • Injection site pain (12%)
  • Nausea (10-11%)
  • Hot flash (7-11%)
  • Fatigue (8-11%)

Please note: These side effects were reported in clinical trials by people who received [[EDITOR|DRUG_DISPLAY_NAME]] 500 mg monthly only. Your side effects can differ if you’re receiving [[EDITOR|DRUG_DISPLAY_NAME]] with other medications.

Less Common Side Effects

  • Headache
  • Back pain
  • Muscle pain
  • Bone pain
  • Pain in the hands and feet

Source: DailyMed

The following Fulvestrant side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or tightness

chills

cloudy urine

cough

difficulty breathing

fainting

fever

hoarseness

irregular heartbeat, recurrent

lower back or side pain

painful or difficult urination

pale skin

pinpoint red spots on the skin

rapid weight gain

sore throat

sores, ulcers, or white spots on the lips or in the mouth

tender, swollen glands in the neck

tingling of the hands or feet

trouble with swallowing

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

Less common

Anxiety

confusion

dizziness or lightheadedness

fast heartbeat

mood or mental changes

muscle cramps in the hands, arms, feet, legs, or face

numbness and tingling around the mouth, fingertips, or feet

pain in the chest, groin, or legs, especially the calves

pain, redness, or swelling in the arm or leg

seizures

severe, sudden headache

slurred speech

stomach cramps

sudden loss of coordination

sudden, severe weakness or numbness in the arm or leg

tremor

vision changes

Incidence not known

Dark urine

flushing or redness of the skin

general feeling of tiredness or weakness

headache

hives or welts, itching, skin rash

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

light-colored stools

nausea

stomach pain, continuing

upper right abdominal pain

vaginal bleeding

vomiting

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

bladder pain

body aches or pain

bone pain

change in or loss of taste

constipation

decreased appetite

depression

diarrhea

difficulty having a bowel movement

difficulty with moving

dry skin

dryness or soreness of the throat

feeling of warmth or heat

feeling sad or empty

frequent urge to urinate

general feeling of discomfort or illness

hair loss or thinning of hair

irritability

joint pain

lack or loss of appetite

lack or loss of strength

loss of interest or pleasure

muscle aches and pains

muscle stiffness

pain at the injection site

pain in the arms or legs

pelvic pain

shivering

stomach pain

sudden sweating

trouble concentrating

voice changes

weight loss

Less common

Dry eye

dry mouth

increased tearing

nervousness

swelling or redness in the joints

Incidence not known

Feeling of constant movement of self or surroundings

sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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