Ofloxacin is a prescription otic medication, or ear drop. It's a fluoroquinolone antibiotic that's used to treat different types of ear infections, such as swimmer's ear and middle ear infection, in adults and children. This medication is given as 5 or 10 drops into the infected ear once or twice a day for 7 or 14 days, depending on your age and the type of ear infection you have. The most common side effect is ear discomfort from applying the drops.
Outer ear infection (swimmer's ear) in people ages 6 months and older
Middle ear infections in children ages 1 year and older with ear tubes
Long-term middle ear infections in people ages 12 years and older with burst eardrums
Ofloxacin is a fluoroquinolone (or "quinolone") antibiotic. It works by blocking certain enzymes (proteins) that bacteria use to grow, repair their genetic material (DNA), and survive. By blocking this process, ofloxacin ear drops kills bacteria.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Puffiness or swelling of eyes
signs of an allergic reaction, such as hives, itching, rash, swelling of face or lips, tightness in chest, troubled breathing, or wheezing
Check with your doctor as soon as possible if any of the following side effects occur:
Rare
Dizziness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Burning of eye
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Works well to treat certain types of ear infections
Can safely use in babies for certain ear infections
Available as a lower-cost generic
Doesn't contain medication to help with ear pain
Must lie still for 5 minutes after placing the drops into the ear to make sure the medication is absorbed
Must warm up the medication in your hands before putting the drops into the ear to prevent dizziness
Only use ofloxacin ear drops in the ear. Don't use it anywhere else in the body. Doing so can be harmful.
Mild irritation or aching in the ear is a common side effect from using ofloxacin ear drops. Though rare, you might get a headache from using this medication as well. Notify a healthcare professional if these side effects don't go away or are severe.
Store ofloxacin ear drops at room temperature. When you're ready to use it, first hold the bottle in your hand for 1 to 2 minutes to warm up the medication. This helps prevent dizziness that you might have if you put cold ear drops into your ear.
Make sure to wash your hands before putting ofloxacin ear drops in your ears. Don't let the dropper tip touch your ear or any other surface, and don't touch the tip with your hands. This helps prevent the ear drops from getting contaminated with germs, which will help you avoid future or worse infections.
Lie down with the affected ear facing upward and put the drops into the ear. For a middle ear infection, push on the tragus (the piece of cartilage that's above the ear lobe) 4 times after you place the drops into the ear to help the medication go into the ear better.
After each time you use ofloxacin ear drops, stay in the lying position with the affected ear facing upwards for at least 5 minutes. Use a clean tissue or cotton ball to lightly wipe away any extra medication that comes out of the ear after you get up.
Use ofloxacin ear drops exactly as prescribed. Don't change your dose or suddenly stop using the drops, even if you feel better. Stopping your antibiotic treatment course too soon can cause the infection to come back and be harder to treat.
Throw away any unused ofloxacin ear drops after you finish your course of treatment.
Ofloxacin ear drops can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Only use ofloxacin ear drops in your ears. Don't give or take this medication any other way, such as swallowed, injected, or placed into the eyes. Ask your primary care provider or pharmacist about other options if you feel this medication isn't the best choice for you or if it's tricky for you to use properly.
Risk factors: Allergy to other fluoroquinolone antibiotics
Severe allergic reactions to ofloxacin ear drops are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (e.g., closing of the throat). Get medical help right away if you notice hives, rash, swelling of the lips or tongue, or difficulty breathing after you use ofloxacin ear drops.
Using ofloxacin ear drops for too long can allow any bacteria and fungi that the medication can't get rid of to overgrow in the ear. Contact your primary care provider for follow up if your ear infection isn't improving after you've used ofloxacin ear drops for one week. You might need additional testing and treatment.
Outer ear infection (swimmer's ear)
Ages 6 months to under 13 years: The typical dose is 5 drops into the affected ear(s) once daily for 7 days.
Ages 13 years and older: The typical dose is 10 drops into the affected ear(s) once daily for 7 days.
Middle ear infection with ear tubes
Ages 1 to 12 years: The typical dose is 5 drops into the affected ear(s) twice daily for 10 days.
Long-term middle ear infection in people with burst eardrums
Ages 12 years and older: The typical dose 10 drops into the affected ear(s) twice daily for 14 days.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Severe allergy to fluoroquinolone antibiotics
Use in the eyes
Outer ear infection (swimmer's ear) in people ages 6 months and older
Middle ear infections in children ages 1 year and older with ear tubes
Long-term middle ear infections in people ages 12 years and older with burst eardrums
Middle ear infections in children with ear tubes
By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.
Apotex Corp. (2023). Ofloxacin otic- ofloxacin solution [package insert]. DailyMed.
Jan, T. A. (2024). Otitis media (chronic suppurative). Merck Manual Consumer Version.
National Human Genome Research Institute. (n.d.). Anatomy of the ear.
Panchasara, A., et al. (2015). Efficacy and safety of ofloxacin and its combination with dexamethasone in chronic suppurative otitis media. A randomised, double blind, parallel group, comparative study. Acta Otorhinolaryngologica Italica.
U.S. Food and Drug Administration. (2019). Combating antibiotic resistance.
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.