Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Cefixime (Suprax) and doxycycline hyclate (Vibramycin, Doryx) are both antibiotics, but they belong to different classes and treat different types of infections. Cefixime is a cephalosporin antibiotic that works by preventing bacteria from making their protective covering, and it is used for infections like urinary tract infections, ear infections, and gonorrhea. Doxycycline hyclate is a tetracycline antibiotic that stops bacteria and parasites from making certain proteins, and it treats conditions such as acne, chlamydia, and Lyme disease. Cefixime is available as a generic and can be taken once a day, while doxycycline hyclate is also available in generic form but is typically taken once or twice daily. Cefixime can cause stomach upset and diarrhea, while doxycycline hyclate can cause sun sensitivity and esophagus irritation. Additionally, doxycycline hyclate is not safe for young children or pregnant women due to risks of tooth discoloration and harm to unborn babies. Both medications require you to finish the entire course even if you start feeling better to prevent resistance.
Cefixime (Suprax)
Doxycycline hyclate
Cefixime (Suprax)
Doxycycline hyclate
Summary of Suprax vs. Vibramycin
Summary for Cephalosporin antibiotic
Prescription only
Cefixime (Suprax) is a cephalosporin antibiotic that treats many types of bacterial infections, but it tends to cause diarrhea and stomach upset, and is more expensive than other similar antibiotics.
•Throat and tonsil infections (strep throat, tonsillitis)
•Bronchitis with bacterial infection
•Gonorrhea
Indications for
Doxycycline hyclate is used to prevent malaria due to the parasite Plasmodium falciparum and to treat many different infections caused by bacteria. Some examples include:
•Respiratory tract infections, including in the nose, throat, and lungs
•Infections caused by ticks, mites, or fleas (Rocky Mountain spotted fever or typhus fever)
•Sexually-transmitted infections (STIs) like chlamydia, gonorrhea, chancroid, and syphilis
•Lyme disease
•Urinary tract infections (UTIs)
•Severe acne
•Anthrax
•Plague
•Cholera
Pros and Cons of Suprax vs. Vibramycin
Pros and Const for Cephalosporin antibiotic
Pros
•Treats many types of bacterial infections
•May be a good choice for people who have gonorrhea and don't like getting shots
•Available as a suspension and chewable tablet for people who cannot swallow pills
•Can be taken once a day, which is convenient
•Available as a generic
Cons
•About 30% of people who take cefixime (Suprax) experience a stomach or intestinal side effect, such as nausea and diarrhea.
•Not recommended to be used for the cold or flu, or for bronchitis that is not bacterial
•If you're allergic to penicillins or other cephalosporin antibiotics, you might not be able to take this medicine.
•Though it is available as a generic, cefixime (Suprax) costs more than other antibiotics that are used for the same types of infections.
Pros and Const for Tetracycline antibiotic
Pros
•Good alternative for some infections if you're allergic to penicillins