Compare Mondoxyne NL vs. Vibramycin

Doxycycline monohydrate (Monodox, Oracea, Vibramycin monohydrate) and doxycycline hyclate (Targadox, Doryx) are both tetracycline antibiotics used to treat a variety of bacterial infections, such as respiratory infections, sexually transmitted infections, and severe acne. They also share the off-label use of treating rosacea. However, there are some differences between the two. Doxycycline hyclate is available in tablets, capsules, liquid syrup, and injectable forms while doxycycline monohydrate is available in capsules and tablets. Doxycycline hyclate is typically taken once or twice daily, whereas doxycycline monohydrate often requires twice-daily dosing for most infections. Doxycycline monohydrate is also specifically used to treat rosacea, with Oracea being a first-choice treatment for this condition. Both medications can cause side effects like nausea, vomiting, and sun sensitivity, but doxycycline hyclate may cause slightly more gut-related side effects. Both medications interact with antacids, blood thinners, and birth control pills, so it's important to discuss these with your healthcare provider.