The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Issues related to tube placement (57%)
- Nausea (30%)
- Constipation (22%)
- Redness around the area where the tube is placed (19%)
- Involuntary movements (dyskinesia, 14%)
- Depression (11%)
- Discharge after the procedure where the tube is placed (11%)
- Swelling in the legs or feet (8%)
- High blood pressure (8%)
- Upper respiratory tract infection (8%)
- Mouth or throat pain (8%)
- Collapsed lung (8%)
Less Common Side Effects
- Confusion
- Anxiety
- Dizziness
- Sleep problems
- Diarrhea
- Indigestion
- Slow gut movement after tube placement
- Stomach hernia
- Fever
- Rash
- Hallucination
- Unusual changes in thoughts or behavior
Duopa serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious stomach problems related to the procedure for tube placement: stomach pain; constipation for more than a few days; nausea; vomiting; fever; blood in your stool; dark, tarry stool
- Falling asleep suddenly or feeling very sleepy
- Hallucinations: seeing things that aren't there, hearing sounds that aren't real, feeling unreal sensations
- Abnormal thinking or behavior: confusion; trouble sleeping; paranoia; delusions; aggression; agitation; strong urges to gamble, shop, or eat
- Heart problems: chest pain that might travel to the arm, neck, or jaw; shortness of breath; cold sweat
- Low vitamin B6: depression, confusion, swollen or sore tongue, cracked corners of your mouth, skin irritation, numbness or tingling in the hands or feet, seizure
- Suicidal thoughts or behavior
- Withdrawal symptoms after stopping suddenly: confusion, very high fevers, sweating, muscle stiffness, irregular pulse, changes in blood pressure
Source: DailyMed
The following Duopa side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting
- Falling asleep during daily activities
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
- Low vitamin B6 level—swollen or sore tongue, cracks at the corners of the mouth, rash, pain, tingling, or numbness in the hands or feet, irritability, confusion, feelings of depression, unusual weakness or fatigue, seizures
- Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
- New or worsening uncontrolled and repetitive movements of the face, mouth, or upper body
- Pain, tingling, or numbness in the hands or feet
- Site infection—skin redness, swelling, warmth, or pain around tube site
- Stomach bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds
- Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
- Urges to engage in impulsive behaviors such as gambling, binge eating, sexual activity, or shopping in ways that are unusual for you
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Dark red or black saliva, sweat, or urine
- Dizziness
- Drowsiness
- Headache
- Nausea
