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CARBIDOPA;LEVODOPA (kar bi DOE pa; lee voe DOE pa) enteral suspension is used to treat certain symptoms of advanced Parkinson's disease. Compare DDCIs.
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Duopa Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Do not stop taking except on your doctor's advice. You may develop a severe reaction. Your doctor will tell you how much medicine is needed.

Talk to your healthcare provider about what you need to do to care for your PEG-J tube site. Watch for signs of infection. Complications in the stomach or intestines can occur from the PEG-J tube procedure. Contact your healthcare provider immediately if you experience stomach pain, constipation that does not go away, nausea, vomiting, fever, or black stools.

If your PEG-J tube becomes kinked, knotted, or blocked this may cause your Parkinson's symptoms to worsen or cause recurring movement problems (motor fluctuations). Call your healthcare provider if your Parkinson's symptoms get worse or you have slow movement while you are treated with this medicine.

Eating high protein foods may affect how this medicine works. Tell your healthcare provider if you change your diet.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

If you find that you have sudden feelings of wanting to sleep during normal activities, like cooking, watching television, or while driving or riding in a car, you should contact your health care professional. Sleepiness and falling asleep suddenly can happen as late as 1 year after you start your treatment.

There have been reports of increased sexual urges or other strong urges such as gambling while taking this medicine. If you experience any of these while taking this medicine, you should report this to your health care provider as soon as possible.

Patients and their families should watch out for new or worsening depression or thoughts of suicide. Call your healthcare provider right away if you feel depressed or have thoughts of suicide.

You may experience a 'wearing off' effect prior to the time for your next dose of this medicine. You may also experience an 'on-off' effect where the medicine apparently stops working for any time from a minute to several hours, then suddenly starts working again. Tell your doctor or health care professional if any of these symptoms happen to you. Your dose may need adjustment.

You should often check your skin for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.

If you have diabetes, you may get a false-positive result for sugar in your urine. Check with your doctor or health care professional.

This medicine may discolor the urine or sweat, making it look darker or red in color. This is of no cause for concern. However, this may stain clothing or fabrics.

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Side Effects to watch for

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • anxiety, confusion, or nervousness
  • blood in your stool or a dark tarry stool
  • chest pain
  • constipation that does not go away
  • falling asleep during normal activities like driving
  • fast, irregular heartbeat
  • hallucination, loss of contact with reality
  • new or increased gambling urges, sexual urges, uncontrolled spending, binge or compulsive eating, or other urges
  • severe nausea and vomiting
  • signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine
  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
  • stomach pain
  • suicidal thoughts or other mood changes
  • uncontrolled movements of the mouth, head, hands, feet, shoulders, eyelids or other unusual muscle movements
  • weakness or numbness or loss of sensation in the fingers or feet

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • headache
  • loss of appetite
  • muscle twitches
  • swelling of legs and feet
  • trouble sleeping

What may interact with this drug?

Do not take this medicine with any of the following medications:

This medicine may also interact with the following medications:

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