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Disopyramide Coupon - Disopyramide 100mg capsule

disopyramide

Generic Norpace
Used for Ventricular Arrhythmia
Used for Ventricular Arrhythmia

Disopyramide (Norpace) is used to treat certain types of arrhythmias (irregular heartbeat). You'll typically first start the medication in a hospital so your provider can monitor you closely. Some common side effects of disopyramide (Norpace) include dry mouth, difficulty urinating, and constipation. It's available as an immediate-release (IR) and extended-release (ER) capsule. While the IR version is available as brand and lower-cost generic, the ER version is only sold under the brand name Norpace CR.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on June 15, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Disopyramide (Norpace)?

What is Disopyramide (Norpace) used for?

How Disopyramide (Norpace) works

Disopyramide (Norpace) is an antiarrhythmic. It slows down abnormal electrical activity in your heart to treat irregular heart rhythm.

Drug Facts

Common BrandsNorpace, Norpace CR
Drug ClassAntiarrhythmic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Disopyramide (Norpace)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth (32%)
  • Trouble starting to urinate or maintaining urine flow (14%)
  • Constipation (11%)
  • Blurred vision (up to 9%)
  • Dry nose, dry eyes, or dry throat (up to 9%)
  • Trouble urinating (up to 9%)
  • Frequent or urgent urination (up to 9%)
  • Nausea (up to 9%)
  • Pain, bloating, or gas (up to 9%)
  • Dizziness (up to 9%)
  • Fatigue or muscle weakness (up to 9%)
  • Headache (up to 9%)
  • Feeling unwell (up to 9%)
  • Aches or pains (up to 9%)

Other Side Effects

  • Erectile dysfunction or difficulty achieving orgasm
  • Low blood pressure
  • Worse heart failure
  • Abnormal heart rhythm
  • Excess fluid under the skin (edema) or weight gain
  • Shortness of breath
  • Fainting
  • Chest pain
  • Poor appetite
  • Diarrhea
  • Rash
  • Nervousness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Low blood pressure or abnormal heart rhythm: chest pain or discomfort, weakness, dizziness, fainting
  • Heart failure: shortness of breath, swelling of feet or ankles, sudden weight gain, dizziness

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Dizziness, feeling of faintness

fainting

heartbeat sensations

shortness of breath

unusual tiredness

Less common

Chest pain

fast or slow heartbeat, rapid weight gain, swelling of feet or lower legs

lightheadedness

rash and/or itching

Rare

Enlargement of breasts in men

fever

mental depression

nosebleeds or bleeding gums

sore throat and fever

yellow eyes or skin

Signs and symptoms of hypoglycemia (low blood sugar)

Anxious feeling

chills

cold sweats

confusion

cool, pale skin

drowsiness

fast heartbeat

headache

hunger (excessive)

nausea

nervousness

shakiness

unsteady walk

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blurred vision

constipation

dry eyes, mouth, nose, or throat

problems with urination

Less common

Bloating or stomach pain

diarrhea

headache

impotence

loss of appetite

muscle weakness

nausea

nervousness

trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Disopyramide (Norpace)

thumbs-up

Pros

Can ask provider to use immediate-release (IR) capsules to make a liquid for children or those who have trouble swallowing pills

Available as a controlled-release (CR) version that's taken less frequently

thumbs-down

Cons

Not a preferred medication if you have heart failure or have had a recent heart attack

Requires close monitoring by provider

IR capsule is taken up to 4 times a day

pharmacist-tips

Pharmacist tips for Disopyramide (Norpace)

pharmacist

  • It's best to take disopyramide (Norpace) around-the-clock, spacing out the doses by the same amount of time. For example, if you need to take the medication 4 times a day, try to take it every 6 hours.

    • You can take disopyramide (Norpace) with or without food.

      • For Norpace CR — the controlled-release (CR) version of disopyramide: Don't crush or chew the capsule because this could cause more medication than normal to be released and raise your risk of side effects. Let your provider know if you have trouble swallowing the whole pills.

        • It's common to have side effects like dry mouth, trouble urinating, and constipation while you're taking disopyramide (Norpace). If they become too bothersome, ask your provider if you can take a lower dose, but don't adjust the dose on your own.

          • Disopyramide (Norpace) can cause serious side effects, such as heart failure, other abnormal heart rhythms, and chest pain. It's important to get regular follow-up and tests done as recommended to catch side effects early on before they become serious.

            • Make sure you tell your provider and pharmacist about all of the medications you take, including supplements, so they can counsel you on drug interactions with disopyramide (Norpace). Using disopyramide (Norpace) with certain medications can be very dangerous because of the risk of serious side effects, including abnormal heart rhythms.

              • There isn't enough information to know if disopyramide (Norpace) is safe to take while you're pregnant or breastfeeding. This medication has been found in breast milk and can potentially harm breastfed babies. Discuss the risks and benefits of taking disopyramide (Norpace) with your provider.

                faqs

                Frequently asked questions about Disopyramide (Norpace)

                Does disopyramide (Norpace) affect blood pressure?
                Yes, it's possible for disopyramide (Norpace) to lower blood pressure. In clinical studies, about 1% to 3% of people who took this medication experienced low blood pressure. This effect is more likely to happen if you already have abnormal heart muscle function, such as heart failure. Let your provider know if you experience low blood pressure while you're taking disopyramide (Norpace). Symptoms of low blood pressure can include dizziness, lightheadedness, weakness, and fainting.
                Can disopyramide (Norpace) be used for atrial fibrillation (AFib)?
                Disopyramide (Norpace) is FDA-approved only to treat ventricular arrhythmias. But, it's been used off-label for atrial fibrillation (AFib), which is a common type of abnormal heart rhythm. It's rarely used for AFib though because the medication has been linked with higher rates of death and often causes bothersome side effects. If you have AFib and your provider chooses to use disopyramide (Norpace), they might give you a different medication first so that disopyramide (Norpace) doesn't cause you to have a heartbeat that's too fast.
                Can disopyramide (Norpace) be used for hypertrophic cardiomyopathy?
                Disopyramide (Norpace) is FDA-approved only to treat ventricular arrhythmias (a type of irregular heart rhythm). But, it has been used off-label for other heart conditions, such as hypertrophic cardiomyopathy (when the heart muscles are abnormally thick and don't pump as well). It isn't considered a first-choice treatment option, but can be helpful for people who don't respond to other medications like beta-blockers and diltiazem (Cardizem).
                Is disopyramide (Norpace) a blood thinner?
                No. Disopyramide (Norpace) isn't a blood thinner. Blood thinners help prevent and treat blood clots. Disopyramide (Norpace) is an antiarrhythmic medication. It slows down the electrical activity of your heart to help treat abnormal heart rhythm.
                Does disopyramide (Norpace) cause hair loss?
                Hair loss wasn't a reported side effect in clinical studies with people who took disopyramide (Norpace). If you notice more hair falling out than usual or your hair becoming thinner, contact your provider. They can help you figure out what's causing it and how to treat it.
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                What are the risks and warnings for Disopyramide (Norpace)?

                Disopyramide (Norpace) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Greater risk of death after recent heart attack

                The Cardiac Arrhythmia Suppression Trial (CAST) was a medical study that showed that it might be harmful and even life-threatening to take certain antiarrhythmic medications to prevent fatal abnormal heart rhythms after a recent heart attack (i.e., within 2 years). Since disopyramide (Norpace) is an antiarrhythmic, it's important to be aware of this risk. And for this reason, disopyramide (Norpace) is usually reserved for people who are already experiencing a life-threatening abnormal heartbeat. If you've had a heart attack recently, your heart specialist will decide which medication is best for you based on your symptoms and electrocardiogram (EKG) results.

                risk-warning

                Low blood pressure and heart failure

                • Risk factors: History of heart failure | Low blood pressure | Heart muscle inflammation (myocarditis) or stiffening (cardiomyopathy)

                  Disopyramide (Norpace) can cause your heart to squeeze less with each beat. This can lead to new or worsening congestive heart failure. Disopyramide (Norpace) can also cause dangerously low blood pressure. You shouldn't take this medication if you already have severe heart failure or low blood pressure, unless it's caused by your arrhythmia condition. If you have any history of abnormal heart muscle function and you need to take disopyramide (Norpace), you'll need closer monitoring. Let your provider know right away if you have symptoms of low blood pressure (e.g, dizziness, lightheadedness, fainting) or heart failure (e.g., shortness of breath, swelling of feet or ankles). You might need to stop taking disopyramide (Norpace).

                  risk-warning

                  Abnormal heart rhythm

                  Disopyramide (Norpace) can slow down the electrical activity in certain parts of your heart. Some changes can lead to life-threatening arrhythmias, including worsened ventricular arrhythmia. Other electrical changes can cause you to have heart block. Your provider will monitor your heart's electrical activity using an electrocardiogram (EKG) on a regular basis and adjust your dose accordingly. If you notice an abnormally slow or fast pulse, chest pain or discomfort, weakness, dizziness, or fainting while taking disopyramide (Norpace), get medical help right away.

                  risk-warning

                  Low blood sugar

                  • Risk factors: Heart failure | Poor nutrition | Liver or kidney problems | Taking other medications that lower blood sugar | Drinking alcohol

                    Although rare, some people had low blood sugar while they were taking disopyramide (Norpace). Getting low blood sugar from disopyramide (Norpace) might be more likely to happen in people with heart failure, poor nutrition, liver or kidney problems, or those who take medications that can affect blood sugar levels. Make sure to watch out for symptoms of low blood sugar, including shakiness, dizziness, sweating, difficulty concentrating, or feeling moody.

                    risk-warning

                    Caution use in people with glaucoma, myasthenia gravis, or urinary retention

                    • Risk factors: Glaucoma | Myasthenia gravis | History of prostate or bladder problems

                      Disopyramide (Norpace) can worsen symptoms of glaucoma, myasthenia gravis, or urinary retention (trouble emptying your bladder, common in men with prostate problems). Tell your provider if you have a family history of glaucoma, since you might need your eye pressure checked before you start disopyramide (Norpace). If you have myasthenia gravis, only take this medication if you don't have any other option since it can trigger a myasthenia gravis "crisis."

                      risk-warning

                      Caution use in people with kidney or liver problems

                      • Risk factors: History of kidney or liver problems

                        Your kidneys are responsible for clearing disopyramide (Norpace) out of the body. Your liver also helps your body break down disopyramide (Norpace). If you have poor kidney or liver function, the medication might stay in the body longer, accumulate (build up), and cause more side effects. Note that having significant heart disease also puts you at risk of having liver problems.

                        To lower the risk of side effects because of poor kidney or liver health, you might need a lower dose of disopyramide (Norpace). Let your provider know if you know you have kidney or liver problems before starting treatment. They'll check your kidney and liver function and prescribe you an appropriate dose. If you have severe kidney problems, you might not be able to take the controlled-release version, Norpace CR.

                        risk-warning

                        Caution use in people with abnormal potassium levels

                        Antiarrhythmics like disopyramide (Norpace) might not work as well if you have low levels of potassium. On the other hand, they might cause more side effects if your potassium levels are too high. Your provider will order blood draws to make sure your potassium levels are normal before giving you disopyramide (Norpace).

                        risk-warning

                        Interactions with other medications

                        Disopyramide (Norpace) can interact with other medications. Some medications, such as phenytoin (Dilantin), can lower the levels of disopyramide (Norpace) in the body. As a result, disopyramide (Norpace) might work less well. Other medications can potentially cause your disopyramide (Norpace) levels to be too high, leading to more side effects. If necessary, your provider can check the level of disopyramide (Norpace) in your blood. Like disopyramide (Norpace), some other antiarrhythmics can cause abnormal electrical activity in the heart; this effect is more likely to happen if you take several antiarrhythmic medications at the same time. Tell your provider and pharmacist about all the medications that you take, so they can help you look out for dangerous interactions.

                        dosage

                        Disopyramide (Norpace) dosage forms

                        The average cost for 60 capsules of 100mg of Disopyramide (Norpace) is $48.24 with a free GoodRx coupon. This is 66.17% off the average retail price of $142.59.
                        capsule
                        Capsule
                        DosageQuantityPrice as low asPrice per unit
                        100mg60 capsules$48.24$0.80
                        150mg60 capsules$62.30$1.04

                        Typical dosing for Disopyramide (Norpace)

                        • Immediate-release capsule (Norpace brand and generic)

                          • Adults: The typical dose is 150 mg by mouth every 6 hours.

                          • Children: Your child's dose will be based on their age and body weight. It's typically given by mouth every 6 hours.

                        • Extended-release capsule (Norpace CR brand)

                          • Adults: The typical dose is 300 mg by mouth every 12 hours.

                          • Children: Ask your child's provider if the extended-release version is right for your child.

                        Your dose might differ if you weigh less than 110 pounds, have kidney or liver problems, or have certain specific heart problems. Your provider might adjust your dose if you experience side effects.

                        interactions

                        Interactions between Disopyramide (Norpace) and other drugs

                        Disopyramide (Norpace) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Disopyramide (Norpace). Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                        How much does Disopyramide (Norpace) cost?

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                        contraindications-icon

                        Disopyramide (Norpace) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Disopyramide (Norpace) will not be safe for you to take.
                        alternatives

                        What are alternatives to Disopyramide (Norpace)?

                        There are a number of medications that your doctor can prescribe in place of Disopyramide (Norpace). Compare a few possible alternatives below.
                        Disopyramide (Norpace)
                        Used for:
                        $48.24 Lowest GoodRx priceView Prices
                        Quinidine
                        Used for:

                        • Treatment of atrial fibrillation or flutter

                        • Prevention of atrial fibrillation or flutter

                        • Prevention of ventricular arrhythmias

                        View Prices
                        Amiodarone (Pacerone)
                        Used for:

                        • Life-threatening ventricular fibrillation that keeps coming back (when other antiarrhythmics haven't worked well)

                        • Life-threatening tachycardia that keeps coming back (when other antiarrhythmics haven't worked)

                        $9.00 Lowest GoodRx priceView Prices
                        images

                        Disopyramide (Norpace) images

                        Blue And Red Biocarft 40 Biocraft 40 And 93 3127 93 3127 - Disopyramide Phosphate 100mg Capsule
                        This medicine is Blue And Red Capsule Imprinted With "93 3127 93 3127" And "Biocarft 40 Biocraft 40".Blue And Red Biocarft 40 Biocraft 40 And 93 3127 93 3127 - Disopyramide Phosphate 100mg Capsule
                        Orange M 095 - Disopyramide Phosphate 100mg Capsule
                        This medicine is Orange Capsule Imprinted With "M 095".Orange M 095 - Disopyramide Phosphate 100mg Capsule

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                        References

                        Best studies we found

                        Echt, D. S., et al. (1991). Mortality and morbidity in patients receiving encainide, flecainide, or placebo – The Cardiac Arrhythmia Suppression Trial. The New England Journal of Medicine.

                        Hindricks, G., et al. (2022). 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal.

                        MedlinePlus. (2022). Cardiogenic shock.

                        View All References (5)

                        National Heart, Lung, and Blood Institute. (2022). Arrhythmias: Long QT syndrome.

                        National Heart, Lung, and Blood Institute. (2022). Arrhythmias: Types.

                        Ommen, S. R., et al. (2020). 2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: A report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. Circulation.

                        Teva Pharmaceuticals USA, Inc. (2022). DISOPYRAMIDE PHOSPHATE capsule [package insert]. DailyMed.

                        Wendell, L. C., et al. (2011). Myasthenic crisis. The Neurohospitalist.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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