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Dihydroergotamine Mesylate

Dihydroergotamine Mesylate Side Effects

Aileen Chu, PharmD, BCPSKristianne Hannemann, PharmD
Reviewed by Aileen Chu, PharmD, BCPS, Kristianne Hannemann, PharmD
Last reviewed on February 22, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Note: Side effects listed below for nasal sprays only.

  • Nose, throat, or sinus irritation (52%, Trudhesa; 6%, Migranal)
  • Runny nose (26%)
  • Nausea (10%)
  • Change in taste (8%)

Less Common Side Effects

  • Vomiting
  • Diarrhea
  • Dizziness
  • Sleepiness
  • Tingling
  • Anxiety
  • Shortness of breath
  • Flushing
  • Sweating
  • Rash

Dihydroergotamine Mesylate serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Poor blood flow: pain, numbness, coldness, pale color in the hands or feet
  • Heart attack: chest pain or tightness, pain in the jaw, neck, or back, shortness of breath
  • Stroke: sudden dizziness, trouble walking or speaking, loss of balance, confusion, weakness on one side of your body in your face, arm, or leg
  • High blood pressure: headache, vision problems
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Source: DailyMed

The following Dihydroergotamine Mesylate side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Chest pain

cough, fever, sneezing, or sore throat

feeling of heaviness in chest

irregular heartbeat

itching of the skin

numbness and tingling of face, fingers, or toes

pain in arms, legs, or lower back

pain in back, chest or left arm

pale bluish-colored or cold hands or feet

shortness of breath or troubled breathing

weak or absent pulses in legs

Symptoms of overdose

Confusion

convulsions (seizures)

delirium

dizziness

headaches

nausea and/or vomiting

numbness, tingling, and/or pain in the legs or arms

shortness of breath

stomach pain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning or tingling sensation, dryness, soreness, or pain in the nose

change in sense of taste

diarrhea

dizziness

dry mouth

fatigue

headache

increased sweating

nausea and or vomiting

muscle stiffness

runny and or stuffy nose

sudden sweatings and feelings of warmth

sensation of burning, warmth, or heat

sore throat

sleepiness

unexplained nose bleeds

unusual tiredness or weakness

Less common

Anxiety

blurred vision

cold clammy skin

confusion

congestion in chest

cough

decreased appetite

depression

difficulty swallowing

dizziness or lightheadedness when getting up from a lying or sitting position

ear pain

eye pain

fever

heartburn

increased watering of eyes

increased watering of the mouth

increased yawning

muscle weakness

nervousness

pinpoint red spots on skin

pounding heartbeat

red or irritated eyes

ringing or buzzing in ears

skin rash

stomach pain

sudden fainting

swelling of face, fingers, feet, or lower legs

trembling or shaking of hands or feet

trouble in sleeping

unusual feeling of well being

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Aileen Chu, PharmD, has over 8 years of experience working as a clinical pharmacist in the emergency department. Chu is also a pharmacotherapeutics instructor at Point Loma Nazarene University.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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