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Diflunisal Coupon - Diflunisal 500mg tablet
DiflunisalGeneric Dolobid
DIFLUNISAL is used to treat osteoarthritis, rheumatoid arthritis, or mild to moderate pain. The lowest GoodRx price for the most common version of diflunisal is around $39.37, 64% off the average retail price of $109.68. Compare NSAIDs.
Prescription Settings
60 tablets
Diflunisal Coupon - Diflunisal 500mg tablet
60 tablets

Diflunisal Side Effects

What should I watch for?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Stomach cramps or pain

Less common

Back or leg pains

bleeding gums

blistering, peeling, loosening of skin

bloody or black, tarry stools

bloody or cloudy urine

blurred or loss of vision

burning feeling in chest or stomach

burning while urinating

clay-colored stools


cough or hoarseness

cracks in the skin

dark-colored urine


difficult or painful urination

difficulty breathing

difficulty swallowing

disturbed color perception


double vision

facial swelling

fast heartbeat

feeling of warmth

fever with or without chills

flu-like symptoms

general body swelling

general feeling of tiredness or weakness

greatly decreased frequency of urination or amount of urine

halos around lights



increased blood pressure

increased thirst



joint or muscle pain

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs

light-colored stools

liver function abnormalities

loss of appetite

loss of heat from the body

lower back or side pain

muscle aches, pains, or weakness

nausea or vomiting

night blindness

noisy breathing


overbright appearance of lights

pale skin

pinpoint red spots on skin

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

red, irritated eyes

redness of the face, neck, arms and occasionally, upper chest

red skin lesions, often with a purple center

red, swollen skin

scaly skin

severe or continuing stomach pain

shortness of breath

skin rash

sores, ulcers, or white spots in mouth or on lips

sore throat

stomach upset

swelling of face, fingers, feet or lower legs

swollen lymph nodes

tenderness in stomach area

tightness in chest

troubled breathing

tunnel vision

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal pain

vomiting of blood or material that looks like coffee grounds

weight gain


yellow eyes or skin

Symptoms of overdose

Change in consciousness

confusion about identity, place, and time

continuing ringing or buzzing or other unexplained noise in ears

decreased awareness or responsiveness

deep or fast breathing with dizziness

fast, pounding, or irregular heartbeat or pulse

hearing loss

loss of consciousness

numbness of feet, hands, and around mouth

severe sleepiness


Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach




stomach discomfort or upset

Less common

Bloated, full feeling

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


dry mucous membranes

excess air or gas in stomach or intestines

feeling of constant movement of self or surroundings

feeling sad or empty

increased sensitivity of skin to sunlight


lack or loss of strength


loss of interest or pleasure

mood or mental changes


passing gas

seeing, hearing, or feeling things that are not there

sensation of spinning

severe sunburn


swelling or inflammation of the mouth


trouble concentrating

trouble sleeping

unable to sleep

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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