The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (5%)
- Headache (5%)
- Rash (4%)
- Abnormal liver function tests (3%)
- Dizziness (2%)
- Urinary tract infections (2%)
- Low blood pressure (2%)
- Shortness of breath (2%)
Less Common Side Effects
- Fatigue
- Weakness
- Joint or muscle pain
- Muscle weakness
- Taste disturbance
- Eye irritation
- Flushing
- Irritated skin (eczema)
Daptomycin serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: sore throat, fever, fatigue, rash, hives, swollen lymph nodes, swelling of the face or lips, trouble breathing
- C. difficile-related diarrhea: fever, stomach pain or cramps, foul-smelling diarrhea, frequent bowel movements (up to 15 times per day)
- Severe muscle damage (rhabdomyolysis): dark brown urine, severe muscle weakness or pain, fever, tiredness
- Serious kidney problems: fever, nausea, vomiting, swelling, weight gain, sleepiness, confusion, urinating less than usual, bloody urine
Source: DailyMed
The following Daptomycin side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Bloating or swelling of the face, arms, hands, lower legs, or feet
rapid weight gain
tingling of the hands or feet
unusual weight gain or loss
Less common
Agitation
black, tarry stools
bladder pain
bloody or cloudy urine
blurred vision
chest pain or discomfort
chills
confusion
decreased awareness or responsiveness
decreased frequency or amount of urine
difficult, burning, or painful urination
dilated neck veins
dizziness
dryness and peeling of the skin
extreme fatigue
fainting
faintness or lightheadedness when getting up suddenly from a lying or sitting position
fast heartbeat
frequent urge to urinate
headache
hostility
increased blood pressure
increased thirst
irregular breathing
irregular heartbeat
irritability
itching in the genital or other skin areas
itching, pain, redness, swelling, tenderness, or warmth on the skin
lightheadedness
loss of appetite
loss of consciousness
lower back or side pain
mood changes
muscle pain or cramps
muscle twitching
nervousness
numbness or tingling in the hands, feet, or lips
pale skin
pounding in the ears
rapid weight gain
rapid, shallow breathing
seizures
severe sleepiness
skin rash
slow or fast heartbeat
sores, ulcers, or white spots on the lips or in the mouth
stomach pain
sweating
swelling of the face, fingers, hands, feet, ankles, or lower legs
swollen glands
tightness in the chest
trouble breathing
unusual bleeding or bruising
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
unusual tiredness or weakness
vomiting of blood or material that looks like coffee grounds
Rare
Bleeding gums
blood in the urine or stools
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
clay-colored stools
dark urine
difficulty with moving
drowsiness
feeling of warmth
feeling unusually cold
general feeling of illness
hoarseness
increase in bone pain
irritation
joint pain, stiffness, or swelling
loss of appetite
mood or mental changes
muscle aching or cramping
muscle spasms (tetany) or twitching
no blood pressure or pulse
pinpoint red spots on the skin
rapid or irregular heartbeat
redness of the face, neck, arms, and occasionally, upper chest
redness, blistering, peeling, or loosening of the skin
shivering
skin rash, encrusted, scaly, and oozing
stopping of the heart
swelling of the eyelids, face, lips, hands, or feet
swollen joints
swollen, painful, or tender lymph glands in the neck, armpit, or groin
trembling
trouble swallowing
twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
unpleasant breath odor
vomiting of blood
yellow eyes or skin
Incidence not known
Diarrhea, watery, and severe, which may also be bloody
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
stomach cramps or tenderness
unusual weight loss
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
difficulty having a bowel movement
Less common
back pain
blurred vision
cold sweats
cool, pale skin
decreased appetite
flushed, dry skin
fruit-like breath odor
increased hunger
increased urination
itching of the vagina or outside genitals
lack or loss of strength
limb pain
nervousness
nightmares
pain during sexual intercourse
shakiness
slurred speech
sweating
thick, white, curd-like vaginal discharge without odor or with mild odor
trouble sleeping
unexplained weight loss
Rare
Bad, unusual, or unpleasant (after) taste
belching
change in taste
continuing ringing or buzzing or other unexplained noise in the ears
excess air or gas in the stomach or intestines
feeling of constant movement of self or surroundings
feeling of fullness
hearing loss
indigestion
pain or discomfort in the chest, upper stomach, or throat
passing gas
pressure in the stomach
red, sore eyes
seeing, hearing, or feeling things that are not there
sensation of spinning
sore mouth or tongue
swelling of the stomach area
swelling or inflammation of the mouth
white patches in the mouth or on the tongue
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
