neomycin / polymyxin b / hydrocortisone
Cortisporin Otic is an ear drop that contains three medications: two antibiotics (neomycin, polymyxin) and a corticosteroid (hydrocortisone). It's a good option for treating outer ear infections in adults and children. The typical dose is to place 3 to 4 drops into the affected ear three to four times a day for up to 10 days. Some people have reported burning and stinging as side effects. Brand name Cortisporin Otic has been discontinued; this medication is only available as a generic.
What is Cortisporin Otic?
What is Cortisporin Otic used for?
How Cortisporin Otic works
Cortisporin Otic is a combination of two antibiotics and a corticosteroid.
Neomycin and polymyxin B are antibiotics that kill bacteria by stopping them from growing.
Hydrocortisone is a corticosteroid that lowers swelling and itching.
Drug Facts
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What are the side effects of Cortisporin Otic?
Common Side Effects
- Burning
- Stinging
Other Side Effects
- Itching
- Dry skin
- Skin irritation
Source:Â DailyMed
The following side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Itching, skin rash, redness, swelling, or other signs of irritation in or around the ear not present before the use of this medicine
Rare
Stinging and burning feeling in the middle ear
Incidence not known
Blood in the urine
change in the frequency of urination or amount of urine
difficulty in breathing
dizziness
drowsiness
feeling of fullness in the ears
increased thirst
loss of appetite
loss of balance
loss of hearing
ringing or buzzing in the ears
swelling of the feet or lower legs
trouble in hearing
vomiting
weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Cortisporin Otic
Pros
Contains three medications that work together to kill the bacteria and treat ear discomfort
Available as a lower-cost generic medication
Can be used with a cotton wick
Cons
One of the antibiotic ingredients (neomycin) can damage hearing.
Might cause burning when applied
Can't be used if you have a torn ear drum or chickenpox
Pharmacist tips for Cortisporin Otic
Store Cortisporin Otic at room temperature. Make sure to tighten the cap after each time you use the medication.
If you're using the Cortisporin Otic suspension, make sure to shake the drops well each time before using them. This isn't necessary if you're using the Cortisporin Otic solution.
Make sure the tip of the Cortisporin Otic bottle doesn't touch anything, such as the skin on your finger or ear as you're administering the medication. This can contaminate (spread germs) the medication.
Don't use Cortisporin Otic drops for more than 10 days as this can lead to unwanted side effects. If the ear infection has not improved by this time, contact your prescriber.
How to use Cortisporin Otic ear drop:
Have the person receiving the Cortisporin Otic ear drops lie on their side with the infected ear facing the ceiling. Add 3 or 4 drops into the ear. Don't move for 5 minutes to let the medication get in the ear. If both ears are infected, repeat this process on the other side.
You can also give Cortisporin Otic using a cotton wick. The wick can be placed in the ear and then soaked with the medication solution. Keep adding solution every 4 hours to keep the wick moist. Change the wick every 24 hours.
Frequently asked questions about Cortisporin Otic
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What are the risks and warnings for Cortisporin Otic?
Cortisporin Otic can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Hearing loss
Risk factors: Using Cortisporin Otic for more than 10 days in a row
Neomycin, one of the antibiotics in Cortisporin Otic, can damage parts of your ear and lead to hearing loss. The risk becomes higher the more often you use this medication. You're unlikely to experience hearing loss from using Cortisporin Otic as directed because this medication is only prescribed short-term. Avoid using this medication for more than 10 days in a row.
Allergic reaction
Risk factors: Sulfite allergy
If the ear becomes more irritated or you see a rash around your ear, stop using Cortisporin Otic and contact your prescriber right away. You might be allergic to one of the medications in Cortisporin Otic or one of the ingredients used to make the solution.
New infection
Cortisporin Otic can cause fungi or untreated bacteria to grow too much and cause another infection. Contact a healthcare professional (HCP) if you or your child complains of fever or pain, or the drainage from the ears hasn't lessened after a week.
Cortisporin Otic dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 10ml | 1 ear dropper | $31.17 | $31.17 |
Typical dosing for Cortisporin Otic
Adults: The typical dose is to place 4 drops into the affected ear 3 or 4 times a day.
Infants and children (smaller ears): The typical dose is to place 3 drops into the affected ear 3 or 4 times a day.
Interactions between Cortisporin Otic and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
How much does Cortisporin Otic cost?
Cortisporin Otic contraindications
Outer ear infection caused by a virus (e.g., herpes simplex virus or varicella zoster virus)
What are alternatives to Cortisporin Otic?
Outer ear canal infections (swimmer's ear or otitis externa) in people age 1 year and older
Outer ear infection (swimmer's ear) in people ages 3 years and older
Cortisporin Otic images
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References
Best studies we foundAmerican Academy of Otolaryngology- Head and Neck Surgery. (n.d.). Patient information: Frequently asked questions: Topical therapy for acute otitis externa (swimmer’s ear).
Bausch & Lomb Incoporated. (2023). Neomycin and polymyxin B sulfates and hydrocortisone- neomycin sulfate, polymyxin b sulfate, hydrocortisone solution/ drops [package insert]. DailyMed.
Bausch & Lomb Incorporated. (2022). Neomycin and polymyxin B sulfates and hydrocortisone- neomycin sulfate, polymyxin b sulfate and hydrocortisone suspension/ drops [package insert]. DailyMed.
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