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What is Theraflu? What to Know About This Over-the-Counter Cold and Flu Medicine

Tegan Smedley, PharmD, APhJoshua Murdock, PharmD, BCBBS
Updated on November 1, 2024

Key takeaways:

  • Theraflu is a brand of combination cold and flu products. Theraflu products contain several over-the-counter (OTC) medications to treat different symptoms. Some are packets you’ll dissolve in warm water and drink (like a tea), while others are pills you swallow.

  • Theraflu helps lessen cold and flu symptoms. But it doesn’t kill the virus causing your infection or help you get better faster.

  • Combination products, such as Theraflu, may be helpful if you have multiple symptoms and prefer to take one product rather than several individual medications. Be sure to check that the symptoms you want to treat match what’s listed on the package.

White mug and saucer with green polka dots with a lemon wedge placed on a couch. There are other cold and flu items surrounding it including: tissues, thermometer, medicine blister pack, and syringe.
Jovanmandic/iStock via Getty Images

Every cold and flu season, the average adult in the U.S. catches at least one cold. And up to 41 million people become sick with the flu. The best protection against getting sick is by getting your flu shot every year and practicing good health habits. Good health habits include routine hand washing, staying home or wearing a mask when you’re sick, and covering your coughs and sneezes. 

If you do catch a cold or the flu, the good news is that many cases are mild and can be treated at home. There are many cold and flu remedies you can buy without a prescription at your local pharmacy. One well-known line of products is Theraflu.

In this article, we’ll take a closer look at Theraflu and how you can get the most out of this over-the-counter (OTC) medication.

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What is Theraflu?

Theraflu is a brand of OTC combination products. It comes in several forms, and typically contains several different OTC medications. Theraflu doesn’t kill the virus that’s making you sick or help you get better faster. But it may help you feel better by easing cold and flu symptoms while your body fights the infection.

Cold and/or flu symptoms include:

  • Headache and body aches

  • Fever

  • Runny or stuffy nose

  • Cough

  • Sneezing

  • Sore throat

  • Chest congestion

Often, the thing people like most about Theraflu is that most of the products come as a powder that you mix into hot water. You can then drink the mixture like a cup of hot tea. Drinking hot liquids may help lessen some of your cold and flu symptoms, although not as well as medications can. So Theraflu in a hot drink provides the best of both worlds.

Good to know: Theraflu doesn’t help you get better faster if you have the flu. But there are prescription medications that do fight the flu virus. For more information, check out this GoodRx article on flu medications.

What are the ingredients in Theraflu?

As mentioned above, Theraflu is a brand of several different combination products. This means that it contains more than one medication. Each medication is included to treat a specific symptom caused by colds and the flu. The medications in Theraflu can be purchased individually. But combination products can lower the number of medications you need to take at one time.

Every Theraflu product contains two to four of the following active ingredients:

Medication

What is it?

What does it treat?

Acetaminophen

Pain reliever / fever reducer

Pain, headache, body aches, fever

Dextromethorphan

Cough suppressant

Cough

Diphenhydramine

Antihistamine

Runny nose, helps you sleep

Chlorpheniramine

Antihistamine

Runny nose, helps you sleep

Pseudoephedrine

Decongestant

Stuffy nose

Phenylephrine

Decongestant

Stuffy nose

Good to know: As of Fall 2023, oral phenylephrine has been found ineffective for congestion. Products containing pseudoephedrine may be a better choice for a stuffy nose. But they’re kept behind the pharmacy counter and have limits on how much and how often you can purchase them.

Does Theraflu work?

Yes. The medications in Theraflu can help relieve common cold and flu symptoms. But as mentioned, they won’t make your cold or flu go away faster. 

Theraflu contains a combination of frequently purchased OTC medications which have been used for years to treat cold and flu symptoms. The effectiveness of each ingredient varies, but many people find cold medications like Theraflu helpful. Be sure to check out our other article on OTC flu medications for more details on how well the individual ingredients work.

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Do combination cold and flu medications work better?

Combination products don’t work better than stand-alone products, but they’re a convenient (and potentially cost-saving) option. You can find the medications in Theraflu sold on their own in most cases. They work the same whether you take them individually or in combination products. But there are a few things to consider when deciding how you want to treat your cold or flu symptoms.

Advantages of combination products like Theraflu include:

  • You’re able to treat multiple symptoms with one product. It’s often simpler to take just one medication that covers your symptoms than to find individual products for each of them.

  • It’s easier to keep track of. It can be difficult to keep track of timing for several medications throughout the day, especially when you don’t feel well. Some medications are given every 4 to 6 hours. Others are given 8 or 12 hours apart. Combination products can make it easier to know when it’s time for your next dose.

  • It may be more cost effective. Since you’re purchasing one product instead of two or more, combination products may be a more affordable option.

There are also several advantages to taking each medication separately:

  • You only take the medication you need. Combination products may contain ingredients for symptoms you don’t have. So taking them means you’re putting medication into your body that you don’t need. This can increase the chance of unwanted side effects.

  • You can adjust the amount you take. Taking medications individually allows you to take a lower or higher dose depending on how severe your symptoms are. Combination products don’t allow you to change the amount of individual medications.

  • You can control when you take it. For example, if a combination product contains an antihistamine that makes you sleepy, you may not want to take it during the day. But with individual products, you can only take the antihistamine in the evening when it won’t interfere with your day.

At the end of the day, choosing Theraflu or another combination product over individual medications comes down to your personal preference.

Types of Theraflu products

All Theraflu products contain two to four of the OTC medications listed in the earlier table. The combination of medications and doses varies between products. But many Theraflu products treat the same symptoms despite having different names.

Theraflu has several products currently on the market:

Theraflu product name

Medications included

Dosage form

Daytime Theraflu-D Flu Relief Max Strength + Nasal Decongestant

Acetaminophen
Dextromethorphan
Pseudoephedrine

Flavored syrup

Nighttime Theraflu-D Flu Relief Max Strength + Nasal Decongestant

Acetaminophen

Chlorpheniramine

Dextromethorphan

Pseudoephedrine

Flavored syrup

Daytime Severe Cold Relief

Acetaminophen
Dextromethorphan

Soft chews

Nighttime Severe Cold Relief

Acetaminophen
Diphenhydramine

Soft chews

Severe Cold Relief (Daytime formula)

Acetaminophen
Dextromethorphan
Phenylephrine

Powder packets

Flavored syrup

Severe Cold Relief (Nighttime formula) 

Acetaminophen
Diphenhydramine
Phenylephrine

Powder packets

Flavored syrup

Daytime Flu Relief Max Strength

Acetaminophen
Dextromethorphan

Powder packets
Flavored syrup

Caplets

Nighttime Flu Relief Max Strength

Acetaminophen
Chlorpheniramine
Dextromethorphan

Powder packets
Flavored syrup

Caplets

Keep in mind that older forms of Theraflu may still be available for purchase. And future formulations may change, especially now that oral phenylephrine has been found ineffective for congestion. Be sure to check the product label to see what ingredients are included in any Theraflu products not listed here.

Which product is right for me?

The right product is the one that matches your symptoms best. Read the package label carefully. Check that the symptoms you want to treat are listed. Also make sure there aren’t extra medications for symptoms you don’t have. It’s also good to note that any product with “nighttime” in its name will likely make you sleepy. 

Theraflu products come in several forms:

  • A powder designed to be dissolved in hot water

  • A ready-to-use syrup

  • Soft chews

  • Caplets

As long as the ingredients match your symptoms, choose the dosage form you prefer. Products with the same ingredients will work the same way. As mentioned above, many people choose Theraflu because they like the warm beverage the powder packets make. It’s also possible that the warm liquid version may start working a bit faster than the caplets or chews. 

If you’re unsure about which form of Theraflu to take, speak with a pharmacist or another healthcare professional. They can help you select the best product for your symptoms.

Who shouldn’t take Theraflu?

Check with your healthcare team before taking Theraflu or any other OTC cold and flu medication. They can check for any drug interactions with your current medications. They can also make sure it’s a safe medication for you based on your medical history. 

Theraflu may not be the best option if you're living with any of the following conditions:

  • Pregnant or nursing

  • Liver problems

  • Heart disease or high blood pressure

  • Glaucoma

  • Trouble urinating due to prostate problems

  • Asthma or chronic obstructive pulmonary disease (COPD)

  • Thyroid problems

  • Diabetes

Theraflu is only for adults and children age 12 years and older. Don’t take Theraflu with other OTC medications that have the same or similar ingredients. Some ingredients, such as acetaminophen, are harmful when taken in large doses. Stop taking Theraflu and check with your healthcare team if your cold or flu symptoms are severe or don’t get better in 7 to 10 days.

What are the side effects of Theraflu?

Theraflu side effects vary depending on what ingredients are in the product you’re taking. The main side effects of the medications in Theraflu products include:

Talk to your pharmacist about other side effects you may experience from the specific Theraflu product you’re taking.

Are there any drug interactions with Theraflu?

Yes. Some medications interact with Theraflu. You should always ask your pharmacist to double check for interactions before starting any OTC medications. They can let you know if they’re safe for you to take.

The following medications may interact with Theraflu:

  • Warfarin (Coumadin, Jantoven). This is a commonly prescribed blood thinner.

  • A class of medications called monoamine oxidase inhibitors (MAOIs). These treat depression and Parkinson’s disease.

Other medications may interact with Theraflu products. Your pharmacist can check your medication list to make sure Theraflu is safe for you.

Frequently asked questions

Can you take Theraflu and Tylenol?

No. You shouldn’t take Theraflu and Tylenol at the same time. Theraflu products already contain acetaminophen, the active ingredient in Tylenol. Taking too much Tylenol at once increases your risk of side effects, such as liver problems.

Can you take Theraflu while pregnant?

It depends. Some Theraflu ingredients, such as acetaminophen, dextromethorphan, and chlorpheniramine, are considered safe to take during pregnancy. But decongestants aren’t recommended while you’re pregnant. It’s always best to check with a pharmacist or your OB/GYN before taking any over the counter medication while you’re pregnant. They can also suggest medication-free treatment options that won’t put you or your baby at risk.

The bottom line

Theraflu is a line of combination products that treats multiple cold or flu symptoms. Common active ingredients in Theraflu products include acetaminophen (a pain reliever), dextromethorphan (a cough suppressant), and diphenhydramine (an antihistamine). Several Theraflu products come as a powder you can mix into hot water and drink for a soothing effect.

It’s best to carefully read the package to make sure you’re only taking medications you need. Speak with your healthcare team to see if Theraflu is a good choice for you. They can also make sure there aren’t any interactions between Theraflu and your current medications.

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Why trust our experts?

Tegan Smedley, PharmD, APh
Tegan Smedley, PharmD, APh, has 10 years of experience as a pharmacist. She has worked in a variety of settings, including retail, hospital, and ambulatory care.
Stacia Woodcock, PharmD
Stacia Woodcock, PharmD, is a pharmacy editor for GoodRx. She earned her Doctor of Pharmacy degree from the University of Kentucky and is licensed in New York and Massachusetts.
Joshua Murdock, PharmD, BCBBS
Joshua Murdock, PharmD, BCBBS, is a licensed pharmacist in Arizona, Colorado, and Rhode Island. He has worked in the pharmacy industry for more than 10 years and currently serves as a pharmacy editor for GoodRx.

References

Centers for Disease Control and Prevention. (2024). About common cold.

Centers for Disease Control and Prevention. (2024). About estimated flu burden.

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Haleon US Holdings LLC. (2024). Theraflu flu relief max strength nighttime- acetaminophen, chlorpheniramine maleate, dextromethorphan hbr syrup [package insert]. DailyMed.

Haleon US Holdings LLC. (2024). Theraflu-d flu relief max strength plus nasal decongestant nighttime- acetaminophen, chlorpheniramine maleate, dextromethorphan hbr, pseudoephedrine hcl syrup [package insert]. DailyMed.

Haleon US Holdings LLC. (2024). Theraflu-d flu relief max strength plus nasal decongestant- acetaminophen, dextromethorphan hbr, pseudoephedrine hcl syrup [package insert]. DailyMed.

Haleon US Holdings LLC. (2024). Theraflu flu relief maximum strength daytime nighttime combo pack- acetaminophen, dextromethorphan hbr and acetaminophen, chlorpheniramine maleate, dextromethorphan hbr kit [package insert]. DailyMed.

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Hodges, L. A., et al. (2014). Does a hot drink provide faster absorption of paracetamol than a tablet? A pharmacoscintigraphic study in healthy male volunteers. Pharmaceutical Research.

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GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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