Treating Major Depressive Disorder: 8 Options if SSRIs Don’t Bring Relief

Medications like antidepressants can provide relief for people living with major depressive disorder (MDD) and other types of depression. The most common type of antidepressant is an SSRI, or selective serotonin reuptake inhibitor. 

If someone doesn’t find relief from an SSRI, there are many other medication options for depression, as well as non-medication options, according to Jacques Ambrose, MD, MPH, FAPA, Psychiatrist at Columbia University Irving Medical Center.

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Written by:

Lauren Smith, MA

Lauren Smith, MA, has worked in health journalism since 2017. Before joining GoodRx, she was the senior health editor and writer for HealthiNation.

Reviewed by:

Mera Goodman, MD, FAAP

Mera Goodman, MD, FAAP, is a board-certified pediatrician. Prior to practicing medicine, she worked as a management consultant.

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