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Depression

How to Know Your Depression Medication Isn’t Working for You

It may take time to figure out if your antidepressant is the right fit.

Lauren Smith, MASanjai Sinha, MD
Written by Lauren Smith, MA | Reviewed by Sanjai Sinha, MD
Updated on July 4, 2025
Featuring Jacques Ambrose, MD, MPH, FAPAReviewed by Sanjai Sinha, MD | July 5, 2025

When you first start a medication for major depressive disorder (or other types of depression), you might be hoping for instant relief. Some people do start feeling better right away, but for others it may take some time. 

Even then, it can be hard to know if the medication is “working” for you. Antidepressants help lessen the symptoms of depression, which is different from making you feel full of bliss, optimism, and satisfaction.

Find out how to determine if your antidepressant is a good fit for you, according to Jacques Ambrose, MD, MPH, FAPA, Psychiatrist at Columbia University Irving Medical Center.

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Lauren Smith, MA
Written by:
Lauren Smith, MA
Lauren Smith, MA, has worked in health journalism since 2017. Before joining GoodRx, she was the senior health editor and writer for HealthiNation.
Sanjai Sinha, MD
Reviewed by:
Sanjai Sinha, MD
Sanjai Sinha, MD, is a board-certified physician with over 20 years of experience. He specializes in internal medicine.

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