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Complement Inhibitors

Complement inhibitors are a type of monoclonal antibody that are used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). They prevent a part of the immune system from harming healthy cells and tissue.

Why are complement inhibitors prescribed?

  1. Myasthenia Gravis (17%)
  2. Anemia (17%)
  3. Macular Degeneration (17%)
  4. Neuromyelitis Optica Spectrum Disorder (17%)
  5. Paroxysmal Nocturnal Hemoglobinuria (17%)
  6. ANCA Associated Vasculitis (17%)

Key takeaways

Complement inhibitors are used to treat conditions like paroxysmal nocturnal hemoglobinuria (PNH), myasthenia gravis (MG), and age-related macular degeneration (AMD). These medications work by blocking portions of the complement system, which is a part of your immune system that can cause inflammation and tissue damage when overactive. Complement inhibitors come in different forms, including oral pills and injections. Examples include Fabhalta (iptacopan), Zilbrysq (zilucoplan), and Izervay (avacincaptad pegol).

Prices for popular Complement Inhibitors medications
Viewing 8 of 8 medications
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Bkemv

as low as$193
Bkemv is part of the Complement Inhibitors class and treats Anemia. Complement inhibitors are a type of monoclonal antibody that are used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). They prevent a part of the immune system from harming healthy cells and tissue. Bkemv is only available as a brand name drug.
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Voydeya

as low as$5,562
Voydeya is part of the Complement Inhibitors class and treats Anemia. Complement inhibitors are a type of monoclonal antibody that are used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). They prevent a part of the immune system from harming healthy cells and tissue. Voydeya is only available as a brand name drug.
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Tavneos

as low as$17,120
AVACOPAN treats autoimmune conditions that cause inflammation in the small blood vessels of the body, such as granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It works by slowing down an overactive immune system. This decreases inflammation.
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Izervay

as low as$20,104
AVACINCAPTAD PEGOL treats macular degeneration, a condition that can cause vision loss. It works by helping to slow changes in vision.
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Zilbrysq

as low as$21,460
ZILUCOPLAN treats myasthenia gravis, a condition that causes muscles to easily weaken or fatigue. It works by decreasing muscle weakness and loss of movement.
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Epysqli

Epysqli is part of the Complement Inhibitors class and treats Myasthenia Gravis and Paroxysmal Nocturnal Hemoglobinuria. Complement inhibitors are a type of monoclonal antibody that are used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). They prevent a part of the immune system from harming healthy cells and tissue. Epysqli is only available as a brand name drug.
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Fabhalta

Fabhalta (Iptacopan) is used to treat Paroxysmal Nocturnal Hemoglobinuria (PNH) and Immunoglobulin A Nephropathy (IgAN). Fabhalta is a Complement Inhibitor, which works by slowing down an overactive immune system. Fabhalta is only available as a brand name drug.
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Soliris

ECULIZUMAB treats certain blood conditions that can cause low levels of red blood cells (anemia) and blood clots, such as atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH). It works by slowing down an overactive immune system, which reduces the breakdown of red blood cells. It also prevents blood cells (platelets) from forming a clot. It may also be used to treat a condition that causes muscles to easily weaken or fatigue (myasthenia gravis).
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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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