Zoryve vs. Vtama for Plaque Psoriasis: Important Differences and Potential Risks.

Zoryve

(roflumilast)

Vtama

(tapinarof)

Summary for Zoryve

Prescription only

Zoryve (roflumilast) is a cream and foam used to treat certain skin conditions in adults and children. Both can be used for plaque psoriasis. The cream is also used for atopic dermatitis (eczema). And, the foam can also be used for seborrheic dermatitis. Zoryve (roflumilast) works as a phosphodiesterase 4 (PDE4) inhibitor to lessen skin inflammation. You apply Zoryve (roflumilast) to the affected area(s) of the skin once a day. Side effects can include headache and nausea.

Indications for Zoryve

Zoryve (roflumilast) cream
- Plaque psoriasis in people 2 years and older - 0.3% cream
- Mild-to-moderate eczema in people 6 years and older - 0.15% cream
- Mild-to-moderate eczema in children 2 to 5 years old - 0.05% cream
Zoryve (roflumilast) 0.3% foam
- Plaque psoriasis on the scalp and body in people 12 years and older
- Seborrheic dermatitis in people 9 years and older

Pros and Cons for Zoryve

Pros

Steroid-free topical medication
Only applied once a day
Few side effects
Generally safe to use for a long time

Cons

Cream not approved for children under 2 years old with eczema
Foam not approved for children under 9 years old with seborrheic dermatitis
Not safe for people with moderate or severe liver conditions
Not known if it's safe to use during pregnancy or while breastfeeding

Common Side Effects for Zoryve

Zoryve (roflumilast) 0.05% cream:

Upper respiratory tract infection (4%)
Diarrhea (3%)
Vomiting (2%)
Runny nose (2%)

Zoryve (roflumilast) 0.15% cream:

Headache (3%)
Nausea (2%)

Zoryve (roflumilast) 0.30% cream:

Diarrhea (3%)
Headache (2%)

Zoryve (roflumilast) 0.30% foam:

Headache (3%)
Diarrhea (3%)
Nausea (2%)

Warnings for Zoryve

Flammable (foam only)

Summary for Vtama

Prescription only

Vtama (tapinarof) is a topical cream that's used to treat plaque psoriasis in adults. It can also treat eczema (atopic dermatitis) in people 2 years of age and older. Unlike other topical treatments for skin conditions, Vtama (tapinarof) isn't a steroid. Instead, it's an aryl hydrocarbon receptor (AhR) agonist. It's thought to boost the activity of AhR, leading to less inflammation in the skin cells and healthier skin. Vtama (tapinarof) is applied to the affected areas once daily. But it can cause side effects on the skin like irritated hair follicles or a rash.

Indications for Vtama

Plaque psoriasis in adults
Eczema in adults and children age 2 and older

Pros and Cons for Vtama

Pros

Only applied onto the affected areas once daily
Can apply to sensitive areas, including the face and skin folds
A different kind of medication that isn't a steroid

Cons

Can cause side effects on the skin, like red bumps and itchy rash
Not FDA approved for all types of inflammatory skin conditions
Not known whether it's safe to use during pregnancy or while breastfeeding

Common Side Effects for Vtama

Plaque psoriasis:

Red, raised bumps around the hair pores (20%)
Symptoms of the common cold (11%)
Rash (7%)

Eczema:

Upper respiratory tract infection (12%)
Red, raised bumps around the hair pores (9%)
Lower respiratory tract infection (5%)

Prices with our coupons for Zoryve vs. Vtama

Zoryve1 tube / 60g of 0.3%

$929.63$1,139.96

Get free coupons

More Information

Vtama1 tube / 60g of 1%

$1,523.61$1,919.82

Get free coupons

More Information

Compare other Plaque Psoriasis drugs

Vtama vs. Zoryve

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.

Compare
Zoryve vs. Vtama

Zoryve

Vtama

Summary for Zoryve

Indications for Zoryve

Pros and Cons for Zoryve

Pros

Cons

Common Side Effects for Zoryve

Warnings for Zoryve

Summary for Vtama

Indications for Vtama

Pros and Cons for Vtama

Pros

Cons

Common Side Effects for Vtama

Prices with our coupons for Zoryve vs. Vtama

Compare other Plaque Psoriasis drugs

Browse medications by letter

Good news for your inbox

Zoryve

Vtama

Summary for Zoryve

Indications for Zoryve

Pros and Cons for Zoryve

Pros

Cons

Common Side Effects for Zoryve

Warnings for Zoryve

Summary for Vtama

Indications for Vtama

Pros and Cons for Vtama

Pros

Cons

Common Side Effects for Vtama