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Compare Vtama vs. Zoryve

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Vtama (tapinarof)
    Zoryve (roflumilast)
  • Vtama (tapinarof)
    Zoryve (roflumilast)

  • Summary of Vtama vs. Zoryve

    Summary for Aryl hydrocarbon receptor agonist
    Prescription only

    Vtama (tapinarof) is a topical cream that's used to treat plaque psoriasis in adults. It can also treat eczema (atopic dermatitis) in people 2 years of age and older. Unlike other topical treatments for skin conditions, Vtama (tapinarof) isn't a steroid. Instead, it's an aryl hydrocarbon receptor (AhR) agonist. It's thought to boost the activity of AhR, leading to less inflammation in the skin cells and healthier skin. Vtama (tapinarof) is applied to the affected areas once daily. But it can cause side effects on the skin like irritated hair follicles or a rash.

    Summary for PDE4 inhibitor
    Prescription only

    Zoryve (roflumilast) is a cream and foam that's approved for treating certain skin conditions in adults and children. The 0.15% cream is used to treat eczema and the 0.3% cream is used to treat plaque psoriasis. The 0.3% foam is approved for seborrheic dermatitis. Zoryve (roflumilast) is a phosphodiesterase 4 (PDE4) inhibitor. It's thought to lessen inflammation on the skin by lowering the activity of a protein in the body called PDE4. Zoryve (roflumilast) is applied to the affected area(s) on the skin once a day. Side effects can include pain where you apply the medication and headache.

  • Indications of Vtama vs. Zoryve

    Indications for
    •Plaque psoriasis in adults
    •Eczema in adults and children age 2 and older
    Indications for
    •Mild-to-moderate eczema in people 6 years and older - 0.15% cream only
    •Plaque psoriasis in people 6 years and older - 0.3% cream only
    •Seborrheic dermatitis in people 9 years and older - 0.3% foam only

  • Pros and Cons of Vtama vs. Zoryve

    Pros and Const for Aryl hydrocarbon receptor agonist
    Pros
    •Only applied onto the affected areas once daily
    •Can apply to sensitive areas, including the face and skin folds
    •A different kind of medication that isn't a steroid
    Cons
    •Can cause side effects on the skin, like red bumps and itchy rash
    •Not FDA approved for all types of inflammatory skin conditions
    •Not known whether it's safe to use during pregnancy or while breastfeeding
    Pros and Const for PDE4 inhibitor
    Pros
    •Steroid-free topical medication
    •Only applied once a day, so it's convenient for most people
    •Generally safe to use for a long period of time
    •Few side effects
    Cons
    •Not safe for people with moderate-to-severe liver conditions
    •Not approved for children under 6 years old with plaque psoriasis or eczema or for children under 9 years old with seborrheic dermatitis
    •No lower-cost generic available; brand-name medication only

  • Common Side Effects of Vtama vs. Zoryve

    Common Side Effects for

    Plaque psoriasis:

    •Red, raised bumps around the hair pores (20%)
    •Symptoms of the common cold (11%)
    •Rash (7%)

    Eczema:

    •Upper respiratory tract infection (12%)
    •Red, raised bumps around the hair pores (9%)
    •Lower respiratory tract infection (5%)
    Common Side Effects for

    Zoryve (roflumilast) 0.15% cream:

    •Headache (3%)
    •Nausea (2%)

    Zoryve (roflumilast) 0.30% cream:

    •Diarrhea (3%)
    •Headache (2%)

    Zoryve (roflumilast) 0.30% foam:

    •Nose and throat inflammation (2%)
    •Headache (1%)

  • Warnings of Vtama vs. Zoryve

    Common Side Effects for
    Common Side Effects for
    •Flammable (foam only)

  • Prices with our coupons for Vtama vs. Zoryve

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    Learn more about Zoryve

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