Key takeaways
Vtama (tapinarof) and Zoryve (roflumilast) are both topical medications used to treat plaque psoriasis and eczema. They are not in the same medication class, though. Vtama is an aryl hydrocarbon receptor (AhR) agonist, while Zoryve is a phosphodiesterase 4 (PDE4) inhibitor. Vtama is approved for plaque psoriasis in adults and eczema in people 2 years and older, whereas Zoryve is approved for plaque psoriasis and eczema in people 2 years and older. Zoryve also comes in a foam form for treating seborrheic dermatitis. Both medications are applied once daily, but Vtama is only available as a cream, while Zoryve is available as both a cream and a foam. Common side effects of Vtama include red bumps and rash, while Zoryve may cause headache and diarrhea. Neither medication has a generic version available.
