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Xanax vs. Prozac

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Alprazolam (Xanax) and fluoxetine (Prozac) are both used to treat mental health conditions, but they work differently and are used for different purposes. Alprazolam is a benzodiazepine that treats generalized anxiety disorder (GAD) and panic attacks. It works quickly, often within 30 minutes, but it can be habit-forming and is meant for short-term use. Common side effects include drowsiness and memory problems. On the other hand, fluoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, obsessive-compulsive disorder (OCD), bulimia, and panic disorder. It takes longer to feel the full effects, usually 1-2 months, and can cause side effects like headaches and difficulty sleeping. Unlike alprazolam, fluoxetine is not habit-forming and is not a controlled substance.

Alprazolam

(Xanax)

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Fluoxetine

(Prozac)

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Summary for Xanax

Prescription only

Alprazolam (Xanax) is a benzodiazepine. It's approved to treat generalized anxiety disorder (GAD) and panic attacks in adults. It's taken by mouth, typically 3 times a day or as directed by your healthcare team. To avoid the risk of dependence, alprazolam (Xanax) is meant for short-term treatment only. Some of the more common side effects of this medication include drowsiness and memory problems. You should avoid drinking alcohol while taking alprazolam (Xanax) because this can lead to serious interactions.

Indications for Xanax

Pros and Cons for Xanax

Pros

  • Taken by mouth
  • Can start to work in 30 minutes
  • Available as quick-dissolving tablets or liquid for people who have trouble swallowing pills

Cons

Common Side Effects for Xanax

Generalized anxiety disorder:

  • Drowsiness (41%)
  • Lightheadedness (21%)
  • Dry mouth (15%)

Panic disorder:

  • Drowsiness (77%)
  • Fatigue (49%)
  • Poor coordination (40%)
  • Memory issues (33%)
  • Irritability (33%)
  • Appetite changes (28-33%)
  • Thinking problems (29%)
  • Constipation (26%)

Side effects listed are for the immediate-release forms. Side effects for extended-release form might differ.

Warnings for Xanax

  • Sedation and difficulty breathing
  • Potential for misuse, addiction, dependence, and withdrawal
  • Effect on driving and concentration
  • Harm to babies
  • Interactions with other medications
  • Use with caution in people with depression

Summary for Prozac

Prescription only

Fluoxetine (Prozac) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat several mental health conditions, including depression and panic disorder. The immediate-release pill and liquid are taken by mouth, typically once or twice daily. The delayed-release capsule is taken weekly, but it's approved only for depression. Some common side effects of fluoxetine (Prozac) include headaches, difficulty sleeping, and tiredness. Don't suddenly stop this medication if you've been taking it for a while; doing so can lead to symptoms of withdrawal.

Indications for Prozac

Pros and Cons for Prozac

Pros

  • Good choice for treating depression, OCD, and panic disorder
  • Less likely to make you sleepy compared to some other antidepressants, such as paroxetine (Paxil)
  • Taken by mouth, typically once daily (IR capsules and liquid) or once weekly (DR capsules, for depression only)
  • Can be taken with or without food

Cons

  • Can take up to 2 months for you to feel the full effects of the medication
  • Can raise the risk of suicidal thoughts and/or behavior in those age 24 or younger
  • Can interact with other medications, especially those affecting serotonin levels
  • Can cause withdrawal symptoms if you suddenly stop taking it

Common Side Effects for Prozac

  • Difficulty falling asleep (up to 33%)
  • Nausea (up to 29%)
  • Headache (21%)
  • Weakness (up to 21%)
  • Diarrhea (up to 18%)
  • Low appetite (up to 17%)
  • Drowsiness (up to 17%)
  • Anxiety (up to 15%)
  • Nervousness (up to 14%)
  • Tremor (up to 13%)
  • Dry mouth (up to 12%)
  • Throat pain (up to 11%)
  • Yawning (up to 11%)
  • Low sex drive (up to 11%)

Warnings for Prozac

  • Worsening depression, suicidal thoughts and behavior
  • Anxiety and trouble sleeping
  • Serotonin syndrome
  • Severe allergic reactions
  • Not for use alone in bipolar disorder
  • Risk of bleeding
  • Glaucoma
  • Low blood sodium levels
  • Life-threatening abnormal heart rhythm (QT prolongation)

Prices with our coupons for Xanax vs. Prozac

Price Card Drug Icon
Alprazolam30 tablets / 0.5mg
$10.40$14.84
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Fluoxetine30 tablets / 20mg
$9.93$78.85
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