Key takeaways
Uribel (hyoscyamine/methenamine/phenyl salicylate/benzoic acid/methylene blue) and Pyridium (phenazopyridine) are both used to relieve urinary symptoms like pain and urgency, often related to urinary tract infections (UTIs). However, they belong to different medication classes. Uribel is a combination medication that acts as a urinary antispasmodic and antiseptic, while Pyridium is an analgesic. Uribel is available by prescription only and is taken four times a day, whereas Pyridium can be purchased over-the-counter or by prescription and is typically taken three times a day for up to two days. Uribel is not available as a generic, while Pyridium is. Uribel can cause your urine and stools to turn blue or blue-green, while Pyridium can turn your urine red-orange. Uribel has a risk of serotonin syndrome if taken with certain psychiatric medications, while Pyridium has fewer drug interactions but can cause issues like hemolytic anemia in people with G6PD deficiency.
