Key takeaways
Tylenol Cold and Flu Severe (acetaminophen/dextromethorphan/guaifenesin/phenylephrine) and Alka-Seltzer Plus Severe Cold and Flu (acetaminophen/chlorpheniramine/dextromethorphan/phenylephrine) are both over-the-counter medications used to relieve symptoms of the common cold and flu, such as cough, congestion, and fever. Both medications contain acetaminophen for pain relief and fever reduction, dextromethorphan as a cough suppressant, and phenylephrine as a decongestant. However, Tylenol Cold and Flu Severe includes guaifenesin, an expectorant that helps loosen mucus, while Alka-Seltzer Plus Severe Cold and Flu contains chlorpheniramine, an antihistamine that helps with runny nose and sneezing. Tylenol Cold and Flu Severe is available in liquid and tablet forms, while Alka-Seltzer Plus comes in capsules, effervescent tablets, and liquid. Side effects aren't common with Tylenol Cold and Flu Severe, but some people get nausea or headache. Alka-Seltzer Plus Severe Cold and Flu may affect your sleep, and some people also experience dry mouth or dizziness. You should avoid taking either medication with other products containing similar ingredients to prevent overdose, especially acetaminophen. Do not monoamine oxidase inhibitors (MAOIs) with either medication due to the risk of serotonin syndrome.
