Key takeaways
Pseudoephedrine (Sudafed) and fluticasone (Flonase) are both used to treat nasal symptoms, but they work in different ways and belong to different medication classes. Pseudoephedrine is a decongestant that works by squeezing the blood vessels in your nose and sinuses to relieve congestion and pressure. It is available over-the-counter but must be purchased at the pharmacy counter due to restrictions. Fluticasone, on the other hand, is a corticosteroid that reduces inflammation in your nose caused by allergies, helping to relieve symptoms like sneezing, runny nose, and itchy eyes. Fluticasone is available both by prescription and over-the-counter. Pseudoephedrine can cause side effects like anxiety and headaches and may keep you awake if taken close to bedtime, while fluticasone can cause nosebleeds and may slow growth in children if used long-term. Pseudoephedrine can raise your blood pressure while fluticasone does not. Additionally, fluticasone must be used daily for maximum benefit, whereas pseudoephedrine can be taken as needed for short-term relief.
